Výsledky vyhledávání - "Panagiotis Fatseas"

Design and Synthesis of Novel Biologically Active Thrombin Receptor Non-Peptide Mimetics Based on the Pharmacophoric Cluster Phe/Arg/NH2 of the Ser42-Phe-Leu-Leu-Arg46 Motif Sequence: Platelet Aggregation and Relaxant Activities

Autor: Demetrios Vlahakos, Thomas Mavromoustakos, John Matsoukas, Euthemia Melissari, Stefan Mihailescu, Maria Christina Paredes-Carbajal, Panagiotis Fatseas, Kostas Alexopoulos, Dieter Mascher, Panagiota Roumelioti

Publikováno v: Journal of Medicinal Chemistry. 47:3338-3352

The identification of the thrombin receptor has promoted the interest for the development of new therapeutic agents capable of selectively inhibiting unwanted biological effects of thrombin on various cell types. In this study we have designed and sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81d22ddfe344cadf90cb619e5902cab
https://doi.org/10.1021/jm031080v

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Design, Synthesis, and Modeling of Novel Cyclic Thrombin Receptor-Derived Peptide Analogues of the Ser42-Phe-Leu-Leu-Arg46 Motif Sequence with Fixed Conformations of Pharmacophoric Groups: Importance of a Phe/Arg/NH2 Cluster for Receptor Activation and Implications in the Design of Nonpeptide Thrombin Receptor Mimetics

Autor: Dimitris Panagiotopoulos, Kostas Alexopoulos, Thomas Mavromoustakos, Dieter Mascher, J. Matsoukas, Maria Christina Paredes-Carbajal, Stefan Mihailescu, Panagiotis Fatseas

Publikováno v: Journal of Medicinal Chemistry. 44:328-339

The novel cyclic analogues cyclo(Phe-Leu-Leu-Arg-eLys-Dap) (1) and cyclo(d-Phe-Leu-Leu-Arg-eLys-Dap) (2), which differ only in the absolute conformation of Phe, have been designed and synthesized b...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d6ccb70f6c3fe6d518676f5dc9bd3d7
https://doi.org/10.1021/jm0001525

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Design and synthesis of thrombin receptor-derived nonpeptide mimetics utilizing a piperazine scaffold

Autor: Morley D. Hollenberg, Julian Smith, Panagiotis Fatseas, Graham J. Moore, Efi Melissari, John Matsoukas, Thomas Mavromoustakos, Demetrios Vlahakos, Mahmoud Saifeddine, Kostas Alexopoulos

Publikováno v: Bioorganic & Medicinal Chemistry 7:6(Jun1999):1033-1041

Focal thrombus formation and vasoconstriction serve to defend vessels when vascular damage occurs, but may be detrimental when an atherosclerotic plaque is disrupted. Recently, the identification of the platelet thrombin receptor opened a new area in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e31e8d9cdbc1c220f9854335a8c6d0
https://doi.org/10.1016/s0968-0896(99)00017-6

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