Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Panagiotis Douvaras"'
Autor:
Panagiotis Douvaras, Diego F. Buenaventura, Bruce Sun, Ashley Lepack, Elizabeth Baker, Elizabeth Simpson, Mark Ebel, Gregory Lallos, Deven LoSchiavo, Nicholas Stitt, Nathaniel Adams, Conor McAuliffe, Ana Forton-Juarez, Brian Kosmyna, Elizabeth Pereira, Benjamin Burnett, David Dilworth, Stephanie Fisher, Jing Wang, Peter Tonge, Mark Tomishima, Carlos Paladini, Dan Wilkinson, Chew-Li Soh, Maya Srinivas, Christoph Patsch, Stefan Irion
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Mucopolysaccharidoses are inherited metabolic disorders caused by the deficiency in lysosomal enzymes required to break down glycosaminoglycans. Accumulation of glycosaminoglycans leads to progressive, systemic degenerative disease. The cent
Externí odkaz:
https://doaj.org/article/95c91876536349f0849eaac799da3482
Autor:
Panagiotis Douvaras, Bruce Sun, Minghui Wang, Ilya Kruglikov, Gregory Lallos, Matthew Zimmer, Cecile Terrenoire, Bin Zhang, Sam Gandy, Eric Schadt, Donald O. Freytes, Scott Noggle, Valentina Fossati
Publikováno v:
Stem Cell Reports, Vol 8, Iss 6, Pp 1516-1524 (2017)
Microglia, the immune cells of the brain, are crucial to proper development and maintenance of the CNS, and their involvement in numerous neurological disorders is increasingly being recognized. To improve our understanding of human microglial biolog
Externí odkaz:
https://doaj.org/article/97f609269643416fa777b936ceb6780e
Autor:
Panagiotis Douvaras, Jing Wang, Matthew Zimmer, Stephanie Hanchuk, Melanie A. O’Bara, Saud Sadiq, Fraser J. Sim, James Goldman, Valentina Fossati
Publikováno v:
Stem Cell Reports, Vol 3, Iss 2, Pp 250-259 (2014)
Multiple sclerosis (MS) is a chronic demyelinating disease of unknown etiology that affects the CNS. While current therapies are primarily directed against the immune system, the new challenge is to address progressive MS with remyelinating and neuro
Externí odkaz:
https://doaj.org/article/8225ab544f01445d8212fcf0ed7a5f37
Autor:
Panagiotis Douvaras, Richard L Mort, Dominic Edwards, Kanna Ramaesh, Baljean Dhillon, Steven D Morley, Robert E Hill, John D West
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71117 (2013)
We aimed to test previous predictions that limbal epithelial stem cells (LESCs) are quantitatively deficient or qualitatively defective in Pax6(+/-) mice and decline with age in wild-type (WT) mice. Consistent with previous studies, corneal epithelia
Externí odkaz:
https://doaj.org/article/c3e3255cbdd045b4923635016e205e80
Autor:
Panagiotis Douvaras, Tomasz Rusielewicz, Kwi Hye Kim, Jeffery D. Haines, Patrizia Casaccia, Valentina Fossati
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 4, p 614 (2016)
Pluripotent stem cells provide an invaluable tool for generating human, disease-relevant cells. Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system, characterized by myelin damage. Oligodendrocytes are the myelin
Externí odkaz:
https://doaj.org/article/c69dee5b2d2d445e8bf60a9fa10f5336
Autor:
Richard L Mort, Adam J Bentley, Francis L Martin, J Martin Collinson, Panagiotis Douvaras, Robert E Hill, Steven D Morley, Nigel J Fullwood, John D West
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28895 (2011)
Altered dosage of the transcription factor PAX6 causes multiple human eye pathophysiologies. PAX6⁺/⁻ heterozygotes suffer from aniridia and aniridia-related keratopathy (ARK), a corneal deterioration that probably involves a limbal epithelial ste
Externí odkaz:
https://doaj.org/article/76f729e253d1417eadba95424dc96e78
Autor:
Lilianne Barbar, Robert H. Miller, Benjamin L.L. Clayton, Valentina Fossati, Mayur Madhavan, Kevin C. Allan, H. Elizabeth Shick, Eric Garrison, Paul J. Tesar, Zachary S. Nevin, Tanya Jain, Cheryl Clarkson-Paredes, Panagiotis Douvaras, Daniel C. Factor, Molly Karl
Publikováno v:
Nature methods
Organoid technologies provide an accessible system to examine cellular composition, interactions, and organization in the developing human brain, but previously have lacked oligodendrocytes, the myelinating glia of the central nervous system. Here we
Autor:
Tianxia Wu, Ruturaj R. Masvekar, Ronald Herbst, Keith Tan, Yue Wang, Panagiotis Douvaras, Mika Komori, Bibiana Bielekova, Mark C. Greenwood, Valentina Fossati, Christopher Barbour, Kory R. Johnson, Peter Kosa, Makoto Tanigawa
Publikováno v:
Annals of Neurology. 82:795-812
Objective: Biomarkers aid diagnosis, allow inexpensive screening of therapies and guide selection of patient-specific therapeutic regimens in most internal medicine disciplines. In contrast, neurology lacks validated measurements of the physiological
Autor:
Caitlin Ravichandran, Amy Kalinowski, Alexandra Staskus, Suzann M. Babb, Donna L. McPhie, Valentina Fossati, Sulagna Ghosh, Bruce M. Cohen, Dost Öngür, Ralda Nehme, Rupinderjit Kaur, Panagiotis Douvaras, Kevin Eggan, Fei Du
Publikováno v:
Translational Psychiatry
Translational Psychiatry, Vol 8, Iss 1, Pp 1-10 (2018)
Translational Psychiatry, Vol 8, Iss 1, Pp 1-10 (2018)
Abnormalities of brain connectivity and signal transduction are consistently observed in individuals with schizophrenias (SZ). Underlying these anomalies, convergent in vivo, post mortem, and genomic evidence suggest abnormal oligodendrocyte (OL) dev
Autor:
Yanzhou Huang, Xianwei Chen, Jianfei Chao, Guihua Sun, Qiuhao Qu, Neville E. Sanjana, Guoqiang Sun, Abdullah Sultan, Charles Warden, Valentina Fossati, Jeremy Klein, Qi Cui, Lizhao Feng, Yanhong Shi, E Tian, Peng Ye, Xinqiang Li, Arthur D. Riggs, Panagiotis Douvaras, Li Li
Alexander disease (AxD) is a leukodystrophy that primarily affects astrocytes and is caused by mutations in the astrocytic filament gene GFAP. While astrocytes are thought to have important roles in controlling myelination, AxD animal models do not r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba7659b033fd52f0fb498e42948c661
https://europepmc.org/articles/PMC6230521/
https://europepmc.org/articles/PMC6230521/