Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Panagiotis, Tourlomousis"'
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0282843 (2023)
Streptococcus pneumoniae is an important cause of fatal pneumonia in humans. These bacteria express virulence factors, such as the toxins pneumolysin and autolysin, that drive host inflammatory responses. In this study we confirm loss of pneumolysin
Externí odkaz:
https://doaj.org/article/d077cbcb7aed406297989b789ccce70e
Autor:
Zsofi Digby, Panagiotis Tourlomousis, James Rooney, Joseph P. Boyle, Betsaida Bibo-Verdugo, Robert J. Pickering, Steven J. Webster, Thomas P. Monie, Lee J. Hopkins, Nobuhiko Kayagaki, Guy S. Salvesen, Soren Warming, Lucy Weinert, Clare E. Bryant
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109614- (2021)
Summary: Zoonotic pathogens, such as COVID-19, reside in animal hosts before jumping species to infect humans. The Carnivora, like mink, carry many zoonoses, yet how diversity in host immune genes across species affect pathogen carriage is poorly und
Externí odkaz:
https://doaj.org/article/bb9d22033809476d95fc1b138b38dc56
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
IL-1β is important for control of bacterial infections, but when deregulated can lead to excessive inflammation. The authors show that the adaptor protein CARD9 suppresses levels of IL-1β and is downregulated during S. Typhimuriuminfection, thus fa
Externí odkaz:
https://doaj.org/article/91099d9564cf4df599100a407c0ed7a7
Autor:
Steve J Webster, Sven Brode, Lou Ellis, Timothy J Fitzmaurice, Matthew J Elder, Nelson O Gekara, Panagiotis Tourlomousis, Clare Bryant, Simon Clare, Ronnie Chee, Hill J S Gaston, Jane C Goodall
Publikováno v:
PLoS Pathogens, Vol 13, Iss 6, p e1006383 (2017)
The innate immune system is a critical component of host defence against microbial pathogens, but effective responses require an ability to distinguish between infectious and non-infectious insult to prevent inappropriate inflammation. Using the impo
Externí odkaz:
https://doaj.org/article/cc7ab21c35704bf99075bec68f1688a5
Autor:
Damiano G. Barone, Alejandro Carnicer-Lombarte, Panagiotis Tourlomousis, Russell S. Hamilton, Malwina Prater, Alexandra L. Rutz, Ivan B. Dimov, George G. Malliaras, Stephanie P. Lacour, Avril A. B. Robertson, Kristian Franze, James W. Fawcett, Clare E. Bryant
Publikováno v:
PNAS
SignificanceImplantable electronic medical devices (IEMDs) are used for some clinical applications, representing an exciting prospect for the transformative treatment of intractable conditions such Parkinson's disease, deafness, and paralysis. The us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfebf6dd6ca6fd2ff0bf247132c87816
https://www.repository.cam.ac.uk/handle/1810/332758
https://www.repository.cam.ac.uk/handle/1810/332758
Autor:
Daniel R. Levy, Atul Udgata, Panagiotis Tourlomousis, Martyn F. Symmons, Lee J. Hopkins, Clare E. Bryant, Nicholas J. Gay
Publikováno v:
The Journal of Biological Chemistry
Leucine-rich repeat kinase 2 (LRRK2) encodes a complex protein that includes kinase and GTPase domains. Genome-wide association studies have identified dominant LRRK2 alleles that predispose their carriers to late-onset idiotypic Parkinson's disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03560d75c05829f543b68ad4f766f221
http://europepmc.org/articles/PMC7397110
http://europepmc.org/articles/PMC7397110
Autor:
Sarah Förster, Tanay Ghosh, Civia Z Chen, Kevin J. Chalut, Björn Neumann, Michael Segel, Adam Young, Panagiotis Tourlomousis, Amar Sharma, Robin J.M. Franklin, Chao Zhao, Juan F. Cubillos, Khalil S. Rawji
Like many adult stem cell populations, the capacity of oligodendrocyte progenitor cells (OPCs) to proliferate and differentiate is substantially impaired with aging. Previous work has shown that tissue-wide transient expression of the pluripotency fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2641e220a6e69363691d562b97aa98fd
https://www.repository.cam.ac.uk/handle/1810/326698
https://www.repository.cam.ac.uk/handle/1810/326698
Autor:
Robert J. Pickering, Lee Hopkins, Panagiotis Tourlomousis, Joseph P. Boyle, James Rooney, Tom P. Monie, Søren Warming, Nobuhiko Kayagaki, Betsaida Bibo-Verdugo, Zsofia Digby, Steve J. Webster, Guy S. Salvesen, Clare E. Bryant, Lucy A. Weinert
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109614-(2021)
Cell Reports
Cell Reports
Summary Zoonotic pathogens, such as COVID-19, reside in animal hosts before jumping species to infect humans. The Carnivora, like mink, carry many zoonoses, yet how diversity in host immune genes across species affect pathogen carriage is poorly unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df4b31528ec19572257040cf0ef6a0e
https://www.repository.cam.ac.uk/handle/1810/326412
https://www.repository.cam.ac.uk/handle/1810/326412
Autor:
Pablo Pelegrín, Helios Martínez-Banaclocha, Panagiotis Tourlomousis, Monique Gangloff, Caroline Lonez, Alberto Baroja-Mazo, Jean Marie Ruysschaert, Malvina Pizzuto, Clare E. Bryant
Publikováno v:
Cellular and molecular life sciences
Cardiolipins (CLs) are tetra-acylated diphosphatidylglycerols found in bacteria, yeast, plants, and animals. In healthy mammals, CLs are unsaturated, whereas saturated CLs are found in blood cells from Barth syndrome patients and in some Gram-positiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabd17d3cd5dc67418011ed27df70e97
https://doi.org/10.1007/s00018-019-03113-5
https://doi.org/10.1007/s00018-019-03113-5
Autor:
Steve J. Webster, Lee Hopkins, Alessandra S Bittante, Duncan J. Maskell, John A. Wright, Clare E. Bryant, Panagiotis Tourlomousis, Owain J. Bryant, Pietro Mastroeni
Publikováno v:
Nat Microbiol
Pattern recognition receptors (PRRs) expressed in antigen-presenting cells are thought to shape pathogen-specific immunity by inducing secretion of co-stimulatory cytokines during T-cell activation, yet data to support this notion in vivo is surprisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3065850fc7b499f509944d89b2a646