Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Panagiota Zarmpi"'
Autor:
M. Alice Maciel Tabosa, Pauline Vitry, Panagiota Zarmpi, Annette L. Bunge, Natalie A. Belsey, Dimitrios Tsikritsis, Timothy J. Woodman, K.A. Jane White, M. Begoña Delgado-Charro, Richard H. Guy
Publikováno v:
Molecular Pharmaceutics. 20:2527-2535
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb84e0e8a822b77a30c3b385856dd975
https://doi.org/10.1021/acs.molpharmaceut.2c01109
https://doi.org/10.1021/acs.molpharmaceut.2c01109
Publikováno v:
Biopharmaceutics. :113-133
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::916bbdb54ef9eaa63f16ca761965b4db
https://doi.org/10.1002/9781119678366.ch8
https://doi.org/10.1002/9781119678366.ch8
Publikováno v:
Fagerberg, J H, Zarmpi, P, Jabbar, H & Fotaki, N 2021, ' Affinity of Lipophilic Drugs to Mixed Lipid Aggregates in Simulated Gastrointestinal Fluids ', Journal of Pharmaceutical Sciences, vol. 110, no. 1, pp. 186-197 . https://doi.org/10.1016/j.xphs.2020.09.053
Mixed lipid aggregates, comprising of bile salts and phospholipids, present in the small intestine assist in drug solubilization and subsequent drug dissolution and absorption through the intestinal epithelium. The increased variability in their leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca67a0cd726ecd4f6056ae6a46860e5
https://purehost.bath.ac.uk/ws/files/214916433/Lipophilic_drugs_and_mixed_aggregates_Dr_N_Fotaki.pdf
https://purehost.bath.ac.uk/ws/files/214916433/Lipophilic_drugs_and_mixed_aggregates_Dr_N_Fotaki.pdf
Autor:
James Mann, Elizabeth Meehan, Panagiota Zarmpi, Talia Flanagan, Nikoletta Fotaki, Jesper Østergaard
Publikováno v:
Zarmpi, P, Flanagan, T, Meehan, E, Mann, J, Østergaard, J & Fotaki, N 2020, ' Biopharmaceutical implications of excipient variability on drug dissolution from immediate release products ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 154, pp. 195-209 . https://doi.org/10.1016/j.ejpb.2020.07.014
Elucidating the impact of excipient variability on oral product performance in a biopharmaceutical perspective would be beneficial and allow excipient implementation on Quality by Design (QbD) approaches. The current study investigated the impact of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53702eca7ccb5ca036f9f37b8c1341e6
https://purehost.bath.ac.uk/ws/files/210941906/Excipient_and_dissolution_Dr_N_Fotaki.pdf
https://purehost.bath.ac.uk/ws/files/210941906/Excipient_and_dissolution_Dr_N_Fotaki.pdf
Publikováno v:
The AAPS Journal
The presence of different excipient types/brands in solid oral dosage forms may affect product performance and drug bioavailability. Understanding the biopharmaceutical implications of superdisintegrant variability (changes in material properties), v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c445ec9b5b01aa9f0310282838c55d
https://doi.org/10.1208/s12248-019-0406-y
https://doi.org/10.1208/s12248-019-0406-y
Publikováno v:
The AAPS Journal
Identification of the biopharmaceutical risks of excipients and excipient variability on oral drug performance can be beneficial for the development of robust oral drug formulations. The current study investigated the impact of Hypromellose (HPMC) pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97352d0b61eec1d5686c009ebd3e6e4
http://europepmc.org/articles/PMC7028811
http://europepmc.org/articles/PMC7028811
Publikováno v:
Zarmpi, P, Flanagan, T, Meehan, E, Mann, J & Fotaki, N 2020, ' Surface dissolution UV imaging for characterization of superdisintegrants and their impact on drug dissolution ', International Journal of Pharmaceutics, vol. 577, 119080 . https://doi.org/10.1016/j.ijpharm.2020.119080
Superdisintegrants are a key excipient used in immediate release formulations to promote fast tablet disintegration, therefore understanding the impact of superdisintegrant variability on product performance is important. The current study examined t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49fafeaad425e46729e5a51733e8741d
https://pubmed.ncbi.nlm.nih.gov/31988030
https://pubmed.ncbi.nlm.nih.gov/31988030
Publikováno v:
Baxevanis, F, Zarmpi, P, Kuiper, J & Fotaki, N 2020, ' Investigation of drug partition kinetics to fat in simulated fed state gastric conditions based on drug properties ', European Journal of Pharmaceutical Sciences, vol. 146, 105263 . https://doi.org/10.1016/j.ejps.2020.105263
The presence of fat in the gastric environment can affect the pharmacokinetic behaviour of drugs with mechanisms which have not been yet fully understood. The objective of the current study was to assess the drug partition to the lipid part of the fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4e1a3258c1546e1cd6ea63ef8b7fc3
https://pubmed.ncbi.nlm.nih.gov/32061656
https://pubmed.ncbi.nlm.nih.gov/32061656
Publikováno v:
The AAPS Journal
Excipients are major components of oral solid dosage forms, and changes in their critical material attributes (excipient variability) and/or amount (excipient variation) in pharmaceutical formulations may present a challenge for product performance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b64d5ba70de76b5420cfd26ad7b478
https://pubmed.ncbi.nlm.nih.gov/32440810
https://pubmed.ncbi.nlm.nih.gov/32440810
Publikováno v:
Zarmpi, P, Flanagan, T, Meehan, E, Mann, J & Fotaki, N 2017, ' Biopharmaceutical aspects and implications of excipient variability in drug product performance ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 111, pp. 1-15 . https://doi.org/10.1016/j.ejpb.2016.11.004
Implementation of Quality by Design approaches in pharmaceutical industry requires a sound understanding of the parameters triggering final product variability. Excipients, although generally regarded as inert components, are of great significance in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c920ff7c9cb34fec3899a9fa3493c927
https://pubmed.ncbi.nlm.nih.gov/27845182
https://pubmed.ncbi.nlm.nih.gov/27845182