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pro vyhledávání: '"Panagiota Zania"'
Autor:
Despina Gourni, Nikos E. Tsopanoglou, Panagiota Zania, Christodoulos S. Flordellis, Alfred C. Aplin, Michael E. Maragoudakis, Roberto F. Nicosia
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 328:378-389
The proteolytic activation by thrombin of the proteinase-activated receptor 1 unveils the tethered peptide ligand and cleaves a 41-amino acid peptide. In this report, we show that this peptide, which we have designated as "parstatin," is a potent inh
Autor:
Panagiota Zania, Christodoulos S. Flordellis, M. E. Papaconstantinou, Michael E. Maragoudakis, Nikos E. Tsopanoglou
Publikováno v:
American Journal of Physiology-Cell Physiology. 294:C1215-C1226
Thrombin has been reported to play a pivotal role in the initiation of angiogenesis by indirectly regulating and organizing a network of angiogenic molecules. In addition, it has been proposed that thrombin can directly activate endothelial cell prol