Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Panagiota S. Georgoulia"'
Publikováno v:
ACS Omega, Vol 3, Iss 11, Pp 14746-14754 (2018)
Externí odkaz:
https://doaj.org/article/b4e877f9e63e4e1cbab2d9ac3d2a29da
Autor:
Panagiota S. Georgoulia, Sinisa Bjelic
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1368 (2021)
Coiled coils represent the simplest form of a complex formed between two interacting protein partners. Their extensive study has led to the development of various methods aimed towards the investigation and design of complex forming interactions. Des
Externí odkaz:
https://doaj.org/article/24eaa25696064988badc460d0683e1a8
Autor:
Wolfgang Bermel, Eduard V. Bocharov, Vladislav Yu. Orekhov, Björn M. Burmann, Irena Matečko-Burmann, Panagiota S. Georgoulia, Dmitry M. Lesovoy, Tammo Diercks
Publikováno v:
Angewandte Chemie (International Ed. in English)
Dysregulation of post‐translational modifications (PTMs) like phosphorylation is often involved in disease. NMR may elucidate exact loci and time courses of PTMs at atomic resolution and near‐physiological conditions but requires signal assignmen
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1863:732-741
Background Abl1 is a protein tyrosine kinase whose aberrant activation due to mutations is the culprit of several cancers, most notably chronic myeloid leukaemia. Several Abl1 inhibitors are used as anti-cancer drugs. Unfortunately, drug resistance l
Publikováno v:
Archives of Biochemistry and Biophysics. 664:76-88
The application of molecular dynamics simulations to study the folding and dynamics of peptides has attracted a lot of interest in the last couple of decades. Following the successful prediction of the folding of several proteins using molecular simu
Autor:
Dmitry M. Lesovoy, Björn M. Burmann, Tammo Diercks, Panagiota S. Georgoulia, Vladislav Yu. Orekhov, Eduard V. Bocharov, Wolfgang Bermel, Irena Matečko-Burmann
Publikováno v:
Angewandte Chemie. 133:23658-23658
Publikováno v:
The FEBS journalReferences. 287(15)
FMS-like tyrosine kinase 3 (FLT3) has been found to be mutated in ~ 30% of acute myeloid leukaemia patients. Small-molecule inhibitors targeting FLT3 that are currently approved or still undergoing clinical trials are subject to drug resistance due t
Publikováno v:
ACS Omega
ACS Omega, Vol 3, Iss 11, Pp 14746-14754 (2018)
ACS Omega, Vol 3, Iss 11, Pp 14746-14754 (2018)
T-20 peptide is the first FDA-approved fusion inhibitor against AIDS/HIV-1 gp41 protein. Part of it, the gp41[659-671] peptide, that contains the complete epitope for the neutralizing 2F5 monoclonal antibody, has been found experimentally in a number
Autor:
Eleftheria Barouni, Panagiota S. Georgoulia, Olga A. Gkini, Athanasios Foukis, Athanasios A. Koutinas, Panagiota-Yiolanda Stergiou, Emmanuel M. Papamichael, Maria Kanellaki, Maria Papagianni
Publikováno v:
Food chemistry. 245
The development of sensitive, easy and reliable methods for the determination of Rhizomucor pusillus rennin (MPR) activity, in free and in immobilized form, along with the elucidation of the mechanism of action, represent challenges for the widesprea
Publikováno v:
The Journal of Physical Chemistry B. 117:5522-5532
Short peptides serve as minimal model systems to decipher the determinants of foldability due to their simplicity arising from their smaller size, their ability to echo protein-like structural characteristics, and their direct implication in force fi