Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Panagiota Kostakis"'
Autor:
Yahya Shehabi, Michael Keane, Amie C. Hayley, Panagiota Kostakis, Con Stough, Luke A. Downey, Maja Green
Publikováno v:
Canadian Society of Forensic Science Journal. 53:1-12
To evaluate the sensitivity of the Securetec DrugWipe 6 S Ketamine device in detecting salivary ketamine, we administered three fixed, increasing sub-anaesthetic doses of intravenous ketamine solut...
Publikováno v:
Psychopharmacology. 235:1273-1282
The acute and delayed effect of analgesic-range doses of ketamine on neurocognitive and behavioural outcomes is understudied. Using a non-controlled open-labelled design, three (1-h duration) increasing intravenous (IV) ketamine infusions comprising
Autor:
Amie C. Hayley, Yahya Shehabi, Brook Shiferaw, Luke A. Downey, Con Stough, Michael Keane, Maja Green, Panagiota Kostakis
Publikováno v:
Progress in neuro-psychopharmacologybiological psychiatry. 86
Ketamine hydrochloride elicits potent psychotomimetic and neurobehavioural effects which make it incompatible with driving; however, the direct effect on driving performance is yet to be assessed. Using an open label, within-subjects protocol, 15 mal
Autor:
Panagiota Kostakis, David R. Haynes, C.A. Holding, Gerald J. Atkins, P. Diamond, Jennifer R. Gamble, David M. Findlay, L.B. To, Andrew C.W. Zannettino, Amanda N. Farrugia
Publikováno v:
Journal of Cellular Physiology. 204:714-723
Recent studies demonstrate roles for osteoprotegerin (OPG) in both skeletal and extra-skeletal tissues. Although its role in preventing osteoclast (OC) formation and activity is well documented, emerging evidence suggests a role of OPG in endothelial
Autor:
Amanda N. Farrugia, Andreas Evdokiou, Gerald J. Atkins, Andrew C.W. Zannettino, Stan Gronthos, Kate Harrison, Beiqing Pan, Panagiota Kostakis, David M. Findlay
Publikováno v:
Journal of Bone and Mineral Research. 18:1088-1098
Human osteoblast phenotypes that support osteoclast differentiation and bone formation are not well characterized. Osteoblast differentiation markers were examined in relation to RANKL expression. RANKL expression was induced preferentially in immatu
Autor:
Stephen Fitter, Panagiota Kostakis, AL Dewar, Timothy P. Hughes, M M Roberts, Barrie Vernon-Roberts, Andrew C.W. Zannettino, L. Bik To, Kevin Lynch
Publikováno v:
Blood. 111(5)
Imatinib inhibits tyrosine kinases important in osteoclast (c-Fms) and osteoblast (platelet-derived growth factor receptor [PDGF-R], c-Abl) function, suggesting that long-term therapy may alter bone homeostasis. To investigate this question, we measu
Autor:
Jeffrey P Houchins, Cristina Vincent, David M. Findlay, Panagiota Kostakis, Andreas Evdokiou, Gerald J. Atkins, Andrew C.W. Zannettino, Amanda N. Farrugia
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 21(9)
RANK expression in vivo on hematopoietic subsets including pre-osteoclasts, identified by monoclonal antibodies, has not been described. We describe the lineages that express RANK in bone marrow, peripheral blood, and GCTs. We show that CD14+RANKhigh
Autor:
Panagiota Kostakis, Cristina Vincent, David M. Findlay, Gerald J. Atkins, Andrew C.W. Zannettino, Katie J. Welldon
Publikováno v:
Journal of cellular physiology. 203(3)
While it has been assumed that osteoblasts in the human support osteoclast formation, in vitro evidence of this is currently lacking. We tested the ability of normal human trabecular bone-derived osteoblasts (NHBCs) to support osteoclast formation fr
Autor:
Damian E. Myers, Matthew T. Gillespie, Vicky Kartsogiannis, William J. McKinstry, Gerald J. Atkins, Chi Ly, Andrew C.W. Zannettino, Kong Wah Ng, Yun Shan Hu, J Elliott, Christine Gange, Julian M.W. Quinn, Brett A. Cromer, Hong Zhou, Panagiota Kostakis, David M. Findlay
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 19(1)
Osteoclast inhibitory lectin (OCIL) is a newly recognized inhibitor of osteoclast formation. We identified a human homolog of OCIL and its gene, determined its regulation in human osteoblast cell lines, and established that it can inhibit murine and
Autor:
Amanda N, Farrugia, Gerald J, Atkins, L Bik, To, Beiqing, Pan, Noemi, Horvath, Panagiota, Kostakis, David M, Findlay, Peter, Bardy, Andrew C W, Zannettino
Publikováno v:
Cancer research. 63(17)
Multiple myeloma (MM) is an incurable B-cell malignancy able to mediate massive destruction of the axial skeleton. The aim of this study was to examine the involvement of the tumor necrosis factor-ligand family member, receptor activator of nuclear f