ADAM8 as a drug target in pancreatic cancer

Autor: Christopher Nimsky, Uwe Schlomann, Fred H. Rasmussen, Madeline Parsons, Catharina Conrad, Rozita Roshani, Sabrina Höfling, Randal R. Ketchem, Panagiota Golfi, Thorsten Hagemann, Miles A. Miller, Maud Bossard, Taheera Ferdous, Patricia Costa, Marcia L. Moss, Joerg W. Bartsch, Garrit Koller, Norbert Sewald, Robin Soper, Douglas A. Lauffenburger, Adolfo Molejon Garcia, David A. Tuveson

Publikováno v: Nature communications

Pancreatic ductal adenocarcinoma (PDAC) has a grim prognosis with less than 5% survivors after 5 years. High expression levels of ADAM8, a metalloprotease-disintegrin, are correlated with poor clinical outcome. We show that ADAM8 expression is associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24212bd3534fcffc3ce23e3a08717af3
https://doi.org/10.1038/ncomms7175

Endosomal accumulation of APP in wobbler motor neurons reflects impaired vesicle trafficking: Implications for human motor neuron disease

Autor: Christopher Shaw, Peter Heimann, Ralf Palmisano, Panagiota Golfi, Joerg W. Bartsch, Thomas Schmitt-John, Claire Troakes

Publikováno v: Palmisano, R, Golfi, P, Heimann, P, Shaw, C, Troakes, C, Schmitt-John, T & Bartsch, J W 2011, ' Endosomal accumulation of APP in wobbler motor neurons reflects impaired vesicle trafficking: Implications for human motor neuron disease ', B M C Neuroscience, vol. 12, pp. 24 .
BMC Neuroscience
BMC Neuroscience, Vol 12, Iss 1, p 24 (2011)
King's College London

Background The cause of sporadic amyotrophic lateral sclerosis (ALS) is largely unknown but hypotheses about disease mechanisms include oxidative stress, defective axonal transport, mitochondrial dysfunction and disrupted RNA processing. Whereas fami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f655329637457bee18701371582caac
https://pure.au.dk/portal/da/publications/endosomal-accumulation-of-app-in-wobbler-motor-neurons-reflects-impaired-vesicle-trafficking-implications-for-human-motor-neuron-disease(759a2643-70f3-48ee-94e3-db2532b050eb).html