Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148

Autor: Jun Fang, Jinping Jia, Matthew Makowski, Mai Xu, Zhaoming Wang, Tongwu Zhang, Jason W. Hoskins, Jiyeon Choi, Younghun Han, Mingfeng Zhang, Janelle Thomas, Michael Kovacs, Irene Collins, Marta Dzyadyk, Abbey Thompson, Maura O'Neill, Sudipto Das, Qi Lan, Roelof Koster, PanScan Consortium, TRICL Consortium, GenoMEL Consortium, Rachael S. Stolzenberg-Solomon, Peter Kraft, Brian M. Wolpin, Pascal W. T. C. Jansen, Sara Olson, Katherine A. McGlynn, Peter A. Kanetsky, Nilanjan Chatterjee, Jennifer H. Barrett, Alison M. Dunning, John C. Taylor, Julia A. Newton-Bishop, D. Timothy Bishop, Thorkell Andresson, Gloria M. Petersen, Christopher I. Amos, Mark M. Iles, Katherine L. Nathanson, Maria Teresa Landi, Michiel Vermeulen, Kevin M. Brown, Laufey T. Amundadottir

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)

Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse tr

Externí odkaz: https://doaj.org/article/6d29a2104a5544a480a010afb3a1a202

Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies.

Autor: Katherine S Elliott, Eleftheria Zeggini, Mark I McCarthy, Julius Gudmundsson, Patrick Sulem, Simon N Stacey, Steinunn Thorlacius, Laufey Amundadottir, Henrik Grönberg, Jianfeng Xu, Valerie Gaborieau, Rosalind A Eeles, David E Neal, Jenny L Donovan, Freddie C Hamdy, Kenneth Muir, Shih-Jen Hwang, Margaret R Spitz, Brent Zanke, Luis Carvajal-Carmona, Kevin M Brown, Australian Melanoma Family Study Investigators, Nicholas K Hayward, Stuart Macgregor, Ian P M Tomlinson, Mathieu Lemire, Christopher I Amos, Joanne M Murabito, William B Isaacs, Douglas F Easton, Paul Brennan, PanScan Consortium, Rosa B Barkardottir, Daniel F Gudbjartsson, Thorunn Rafnar, David J Hunter, Stephen J Chanock, Kari Stefansson, John P A Ioannidis

Publikováno v: PLoS ONE, Vol 5, Iss 5, p e10858 (2010)

BackgroundGenome-wide association studies have found type 2 diabetes-associated variants in the HNF1B gene to exhibit reciprocal associations with prostate cancer risk. We aimed to identify whether these variants may have an effect on cancer risk in

Externí odkaz: https://doaj.org/article/ed86bff323304eb0bb405d306b665368

The association between genetically elevated polyunsaturated fatty acids and risk of cancer

Autor: Haycock, Philip C, Borges, Maria Carolina, Burrows, Kimberley, Lemaitre, Rozenn N, Burgess, Stephen, Khankari, Nikhil K, Tsilidis, Konstantinos K, Gaunt, Tom R, Hemani, Gibran, Zheng, Jie, Truong, Therese, Birmann, Brenda M, OMara, Tracy, Spurdle, Amanda B, Iles, Mark M, Law, Matthew H, Slager, Susan L, Saberi Hosnijeh, Fatemeh, Mariosa, Daniela, Cotterchio, Michelle, Cerhan, James R, Peters, Ulrike, Enroth, Stefan, Gharahkhani, Puya, Le Marchand, Loic, Williams, Ann C, Block, Robert C, ACCC, CCFR-CORECT-GECCO, EPITHYR, InterLymph, MMAC, ECAC, ILCCO, PRACTICAL Consortium, PanScan, PanC4, Amos, Christopher I, Hung, Rayjean J, Zheng, Wei, Gunter, Marc J, Smith, George Davey, Relton, Caroline, Martin, Richard M, Fatty Acids in Cancer Mendelian Randomization Collaboration

BACKGROUND: The causal relevance of polyunsaturated fatty acids (PUFAs) for risk of site-specific cancers remains uncertain. METHODS: Using a Mendelian randomization (MR) framework, we assessed the causal relevance of PUFAs for risk of cancer in Euro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______109::ebfca62874c661f67eebb2bebd9149d8
https://www.repository.cam.ac.uk/handle/1810/349993

Large-scale cross-cancer fine-mapping of the 5p15.33 region reveals multiple independent signals

Autor: Chen, H, Majumdar, A, Wang, L, Kar, S, Brown, KM, Feng, H, Turman, C, Dennis, J, Easton, D, Michailidou, K, Simard, J, Breast Cancer Association Consortium (BCAC), Bishop, T, Cheng, IC, Huyghe, JR, Schmit, SL, Colorectal Transdisciplinary Study (CORECT), Colon Cancer Family Registry Study (CCFR), Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO, O'Mara, TA, Spurdle, AB, Endometrial Cancer Association Consortium (ECAC), Gharahkhani, P, Schumacher, J, Jankowski, J, Gockel, I, Esophageal Cancer GWAS Consortium, Bondy, ML, Houlston, RS, Jenkins, RB, Melin, B, Glioma International Case Control Consortium (GICC), Lesseur, C, Ness, AR, Diergaarde, B, Olshan, AF, Head-Neck Cancer GWAS Consortium, Amos, CI, Christiani, DC, Landi, MT, McKay, JD, International Lung Cancer Consortium (ILCCO), Brossard, M, Iles, MM, Law, MH, MacGregor, S, Melanoma GWAS Consortium, Beesley, J, Jones, MR, Tyrer, J, Winham, SJ, Ovarian Cancer Association Consortium (OCAC), Klein, AP, Petersen, G, Li, D, Wolpin, BM, Pancreatic Cancer Case-Control Consortium (PANC4), Pancreatic Cancer Cohort Consortium (PanScan), Eeles, RA, Haiman, CA, Kote-Jarai, Z, Schumacher, FR, PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS, Brennan, P, Chanock, SJ, Gaborieau, V, Purdue, MP, Renal Cancer GWAS Consortium, Pharoah, P, Hung, RJ, Amundadottir, LT, Kraft, P, Pasaniuc, B, Lindström, S

Genome-wide association studies (GWASs) have identified thousands of cancer risk loci revealing many risk regions shared across multiple cancers. Characterizing the cross-cancer shared genetic basis can increase our understanding of global mechanisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::f7ccf5c2520351e85e2a8b9f18bbb9e3
https://eprints.whiterose.ac.uk/177648/6/1-s2.0-S2666247721000221-main.pdf

Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer

Autor: Paula L. Hyland, Sonja I. Berndt, Michelle Cotterchio, Rayjean J. Hung, Stephen K. Van Den Eeden, Núria Malats, Sara H. Olson, Rachel E. Neale, Eric A. Klein, Gloria M. Petersen, Eric J. Duell, Ann L. Oberg, Naomi Walsh, Robert C. Kurtz, Kari G Chaffee, Anne Zeleniuch-Jacquotte, Elisabete Weiderpass, Elizabeth A Holly, Brian M. Wolpin, Vladimir Janout, Lauren K. Brais, Paul Brennan, Qi Yang, Federico Canzian, Patricia Hartge, Han Zhang, Irene Collins, Peter Kraft, S. Chanock, Satu Männistö, PanScan, Christopher A. Haiman, Erica J. Childs, Wei Zheng, Robert N. Hoover, Malin Sund, Ayelet Borgida, Joseph M. Herman, Rachael Z. Stolzenberg-Solomon, Harvey A. Risch, Gabriella Andreotti, Oliver Strobel, Julie E. Buring, Kala Visvanathan, Ivana Holcatova, Nicholas J. Wareham, Paige M. Bracci, Nathaniel Rothman, Zhaoming Wang, Alison P Klein, Howard D. Sesso, Graham G. Giles, Gary E. Goodman, Edward Giovannucci, Michael Goggins, Emily White, Demetrius Albanes, Phyllis J. Goodman, Sean Cleary, Roger L. Milne, Francisco X. Real, Kathy J. Helzlsouer, Miquel Porta, Charles S. Fuchs, B. Bueno-de-Mesquita, Thilo Hackert, Lingeng Lu, Ghislaine Scelo, Marie-Christine Boutron-Ruault, Ana Babic, Herbert Yu, Laura Beane-Freeman, PanC consortia, J. Michael Gaziano, Laufey T. Amundadottir, Mark D Thornquist, I-Min Lee, Ulrike Peters, Mingfeng Zhang, Donghui Li, Eric J. Jacobs, Evelina Mocci, William Wheeler, Kai Yu, William R. Bamlet, Gianluca Severi, Xiao O. Shu, Alpa V. Patel, Alan A. Arslan, Charles Kooperberg, D. Silverman, Daniel Laheru, Irene Orlow, Steven Gallinger, J. Wactawski-Wende, Geoffrey S Tobias, Loic LeMarchand, Nicolas Wentzensen, Lenka Foretová, Manal Hasan

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname

Background: Genome-wide association studies (GWAS) identify associations of individual single-nucleotide polymorphisms (SNPs) with cancer risk but usually only explain a fraction of the inherited variability. Pathway analysis of genetic variants is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b7df9a06e73d947d76d98c005626354
https://doi.org/10.1093/jnci/djy155