Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Pan Yue Deng"'
Publikováno v:
eLife, Vol 12 (2024)
Abnormal cellular and circuit excitability is believed to drive many core phenotypes in fragile X syndrome (FXS). The dentate gyrus is a brain area performing critical computations essential for learning and memory. However, little is known about den
Externí odkaz:
https://doaj.org/article/c2a91812bf7b41a9a3c16977a974f3d6
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110820- (2022)
Summary: Fragile X syndrome, the most common inherited form of intellectual disability, is caused by loss of fragile X mental retardation protein (FMRP). GABAergic system dysfunction is one of the hallmarks of FXS, yet the underlying mechanisms remai
Externí odkaz:
https://doaj.org/article/79648acea60d4959a517f69d3e998ea4
Autor:
Oshri Avraham, Pan-Yue Deng, Sara Jones, Rejji Kuruvilla, Clay F. Semenkovich, Vitaly A. Klyachko, Valeria Cavalli
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The contribution of satellite glia to peripheral nerve regeneration is unclear. Here, the authors show that satellite glia are transcriptionally distinct from Schwann cells, share similarities with astrocytes, and, upon injury, they contribute to axo
Externí odkaz:
https://doaj.org/article/d446500304ea4ebe9944be716f685078
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2022)
Among most prevalent deficits in individuals with Fragile X syndrome (FXS) is hypersensitivity to sensory stimuli and somatosensory alterations. Whether dysfunction in peripheral sensory system contributes to these deficits remains poorly understood.
Externí odkaz:
https://doaj.org/article/66013fa559984556826675053795ce6e
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Sensory hypersensitivity and somatosensory deficits represent the core symptoms of Fragile X syndrome (FXS). These alterations are believed to arise from changes in cortical sensory processing, while potential deficits in the function of peripheral s
Externí odkaz:
https://doaj.org/article/3b40e83211b94b5aa5f73209ab6183d1
Autor:
Cheng Cheng, Pan-Yue Deng, Yoshiho Ikeuchi, Carla Yuede, Daofeng Li, Nicholas Rensing, Ju Huang, Dustin Baldridge, Susan E. Maloney, Joseph D. Dougherty, John Constantino, Arezu Jahani-Asl, Michael Wong, David F. Wozniak, Ting Wang, Vitaly A. Klyachko, Azad Bonni
Publikováno v:
Cell Reports, Vol 25, Iss 6, Pp 1404-1414.e6 (2018)
Summary: Mutations of the transcriptional regulator PHF6 cause the X-linked intellectual disability disorder Börjeson-Forssman-Lehmann syndrome (BFLS), but the pathogenesis of BFLS remains poorly understood. Here, we report a mouse model of BFLS, ge
Externí odkaz:
https://doaj.org/article/5107bf2f06fd4114b0bd1ec237ef6f50
Autor:
Pan-Yue Deng, Vitaly A. Klyachko
Publikováno v:
Cell Reports, Vol 16, Iss 12, Pp 3157-3166 (2016)
Altered neuronal excitability is one of the hallmarks of fragile X syndrome (FXS), but the mechanisms underlying this critical neuronal dysfunction are poorly understood. Here, we find that pyramidal cells in the entorhinal cortex of Fmr1 KO mice, an
Externí odkaz:
https://doaj.org/article/6ce14abee9ae41e6bb7748679a3a7290
Publikováno v:
Cell Rep
Fragile X syndrome, the most common inherited form of intellectual disability, is caused by loss of fragile X mental retardation protein (FMRP). GABAergic system dysfunction is one of the hallmarks of FXS, yet the underlying mechanisms remain poorly
Autor:
Pan-Yue Deng, Stephen T. Warren, Leila K. Myrick, Vitaly A. Klyachko, Valeria Cavalli, Young Mi Oh, Dan Carlin
Publikováno v:
The Journal of Neuroscience. 39:28-43
Neuronal hyperexcitability is one of the major characteristics of fragile X syndrome (FXS), yet the molecular mechanisms of this critical dysfunction remain poorly understood. Here we report a major role of voltage-independent potassium (K+)-channel
Autor:
Vitaly A. Klyachko, Pan Yue Deng
Publikováno v:
Nat Rev Neurosci
Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and the leading monogenic cause of autism. The condition stems from loss of fragile X mental retardation protein (FMRP), which regulates a wide range of ion channel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e5bf596ae85eefc945bf81992dba1a
https://europepmc.org/articles/PMC8863066/
https://europepmc.org/articles/PMC8863066/