Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Pan Pantziarka"'
Autor:
Miriam Dixon-Zegeye, Rachel Shaw, Linda Collins, Kendra Perez-Smith, Alexander Ooms, Maggie Qiao, Pan Pantziarka, Louise Izatt, Marc Tischkowitz, Rachel E. Harrison, Angela George, Emma R. Woodward, Simon Lord, Lara Hawkes, D. Gareth Evans, James Franklin, Helen Hanson, Sarah P. Blagden
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Background Li-Fraumeni syndrome (LFS) is a rare autosomal dominant disease caused by inherited or de novo germline pathogenic variants in TP53. Individuals with LFS have a 70–100% lifetime risk of developing cancer. The current standard of
Externí odkaz:
https://doaj.org/article/cf49679192c94035afcc32e77d21fae6
Autor:
Denise Robinson, Hugh Leonard, Giacomo Giulio Baldi, William D. Tap, Robin L. Jones, Silvia Stacchiotti, Pan Pantziarka
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundEpithelioid hemangioendothelioma (EHE) is an ultra-rare, vascular sarcoma with clinical presentation ranging from an indolent to an aggressive form. Over 50% of patients present with metastatic disease, requiring systemic therapy, although
Externí odkaz:
https://doaj.org/article/9df29e33f2964648aa04e88d03235fc3
Autor:
Florian Lüke, Dennis Christoph Harrer, Pan Pantziarka, Tobias Pukrop, Lina Ghibelli, Christopher Gerner, Albrecht Reichle, Daniel Heudobler
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The combinatory use of drugs for systemic cancer therapy commonly aims at the direct elimination of tumor cells through induction of apoptosis. An alternative approach becomes the focus of attention if biological changes in tumor tissues following co
Externí odkaz:
https://doaj.org/article/e9cddf90b49d4395930e3c6b358fab04
Autor:
Elizabeth Ann Roundhill, Pan Pantziarka, Danielle E. Liddle, Lucy A. Shaw, Ghadeer Albadrani, Susan Ann Burchill
Publikováno v:
Cancers, Vol 15, Iss 3, p 769 (2023)
Outcomes for most patients with Ewing sarcoma (ES) have remained unchanged for the last 30 years, emphasising the need for more effective and tolerable treatments. We have hypothesised that using small-molecule inhibitors to kill the self-renewing ch
Externí odkaz:
https://doaj.org/article/9be5ddb7b69a4332b25e6930fc108cff
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/8941062e3d0c457c90e7e3a8b54b3891
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Vaccines used to prevent infections have long been known to stimulate immune responses to cancer as illustrated by the approval of the Bacillus Calmette–Guérin (BCG) vaccine to treat bladder cancer since the 1970s. The recent approval of immunothe
Externí odkaz:
https://doaj.org/article/8c7f574ce33c4c72b9dad9844373ab58
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
A global, comprehensive and open access listing of approved anticancer drugs does not currently exist. Partial information is available from multiple sources, including regulatory authorities, national formularies and scientific agencies. Many such d
Externí odkaz:
https://doaj.org/article/86a2ecc5b4d547199735cd3630fa58de
Autor:
Pan Pantziarka, Sarah Blagden
Publikováno v:
Cancers, Vol 14, Iss 7, p 1621 (2022)
The concept of the pre-cancerous niche applies the ‘seed and soil’ theory of metastasis to the initial process of carcinogenesis. TP53 is at the nexus of this process and, in the context of Li-Fraumeni Syndrome (LFS), is a key determinant of the
Externí odkaz:
https://doaj.org/article/14225ce3c88f44d2bfa09cbc949b05d2
Autor:
Albrecht Reichle, Daniel Heudobler, Christopher Gerner, Pan Pantziarka, Eugenio Martinelli, Ernst Holler, Francesca Corsi, Lina Ghibelli
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Externí odkaz:
https://doaj.org/article/f6e9c54834c843e5bb0e0f97586f2152
Autor:
Daniel Heudobler, Florian Lüke, Martin Vogelhuber, Sebastian Klobuch, Tobias Pukrop, Wolfgang Herr, Christopher Gerner, Pan Pantziarka, Lina Ghibelli, Albrecht Reichle
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
The current approach to systemic therapy for metastatic cancer is aimed predominantly at inducing apoptosis of cancer cells by blocking tumor-promoting signaling pathways or by eradicating cell compartments within the tumor. In contrast, a systems vi
Externí odkaz:
https://doaj.org/article/2e9ec085b01a41b096949a5fc7a6133d