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PREVAPIX-ALL: Apixaban Compared to Standard of Care for Prevention of Venous Thrombosis in Paediatric Acute Lymphoblastic Leukaemia (ALL)-Rationale and Design

Autor: Danshi Li, Donald L. Yee, Sarah H. O'Brien, Lillian Sung, Jane W. Newburger, Pamela Zee, Lesley G. Mitchell, Thomas A. Hess, Vilmarie Rodriguez

Publikováno v: Thrombosis and haemostasis. 119(5)

Venous thromboembolic (VTE) complications in children and adolescents with acute lymphoblastic leukaemia (ALL) and T or B cell lymphoblastic lymphoma (T/B cell LL) can result not only in life-threatening acute complications but also contribute to sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de2490c51f39e089ae57c0ea16a0915
https://pubmed.ncbi.nlm.nih.gov/30861550

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Quantitative Extrapolation: An Approach to Validation of Adult Drug Efficacy in Pediatric Subjects

Autor: Satyendra Suryawanshi, Christoph Male, Tarek A. Leil, Ronald J. Portman, Pamela Zee

Publikováno v: Therapeutic innovationregulatory science. 47(5)

Confirmation of efficacy in pediatric drug development has traditionally required large, fully powered efficacy studies that have proven to have major feasibility and ethical challenges. Extrapolation of efficacy in the framework provided by the US F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c49be230b5934535efac25151792de
https://pubmed.ncbi.nlm.nih.gov/30235580

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Dual Add-on Therapy in Type 2 Diabetes Poorly Controlled With Metformin Monotherapy: A Randomized Double-Blind Trial of Saxagliptin Plus Dapagliflozin Addition Versus Single Addition of Saxagliptin or Dapagliflozin to Metformin

Autor: William Cook, Boaz Hirshberg, Pamela Zee, Julio Rosenstock, Lars Hansen, Yan Li, Nayyar Iqbal

Publikováno v: Diabetes Care. 38:376-383

OBJECTIVE This study compared the efficacy and safety of dual add-on of saxagliptin plus dapagliflozin versus saxagliptin and dapagliflozin added on alone in patients with type 2 diabetes poorly controlled with metformin. RESEARCH DESIGN AND METHODS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9891500eef13a86521593712e1534874
https://doi.org/10.2337/dc14-1142

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Willow hybridization differentially affects preference and performance of herbivorous beetles

Autor: Pamela Zee, Robert S. Fritz, Minh Tam T. Dao, Colin M. Orians, Alexander L. Wild, Katherine A. Dorfman, Cynthia H. Huang

Publikováno v: Entomologia Experimentalis et Applicata. 83:285-294

We examined the preferences and performances of five beetle species (four chrysomelids and one scarab) on two species of willows (Salix sericea and S. eriocephala) and their interspecific hybrids. Beetle species differed markedly in their responses.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e73b6d407ef9dca01104d12d4ce730fe
https://doi.org/10.1046/j.1570-7458.1997.00183.x

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