Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Pamela Y. Sandoval"'
Autor:
Shefeeq M. Theparambil, Patrick S. Hosford, Iván Ruminot, Olga Kopach, James R. Reynolds, Pamela Y. Sandoval, Dmitri A. Rusakov, L. Felipe Barros, Alexander V. Gourine
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Several mechanisms contribute to the maintenance of constant extracellular pH, essential for normal brain function. Here the authors show that astrocytes help to control local brain pH via a neuronal activity-dependent release of bicarbonate by the e
Externí odkaz:
https://doaj.org/article/1524bdcca8db439a89cd7a17717a5a6c
Autor:
Robinson Arce-Molina, Francisca Cortés-Molina, Pamela Y Sandoval, Alex Galaz, Karin Alegría, Stefanie Schirmeier, L Felipe Barros, Alejandro San Martín
Publikováno v:
eLife, Vol 9 (2020)
Mitochondria generate ATP and building blocks for cell growth and regeneration, using pyruvate as the main substrate. Here we introduce PyronicSF, a user-friendly GFP-based sensor of improved dynamic range that enables real-time subcellular quantitat
Externí odkaz:
https://doaj.org/article/c6090b42fdf74bd39ba8165b70422be2
Autor:
Dominique I. Furrer, Estienne C. Swart, Matthias F. Kraft, Pamela Y. Sandoval, Mariusz Nowacki
Publikováno v:
Cell Reports, Vol 20, Iss 2, Pp 505-520 (2017)
Piwi proteins and piRNAs protect eukaryotic germlines against the spread of transposons. During development in the ciliate Paramecium, two Piwi-dependent sRNA classes are involved in the elimination of transposons and transposon-derived DNA: scan RNA
Externí odkaz:
https://doaj.org/article/9bc960ffac0c4664aea00a7aef70105c
Autor:
Yasna Contreras-Baeza, Sebastián Ceballo, Robinson Arce-Molina, Pamela Y Sandoval, Karin Alegría, Luis Felipe Barros, Alejandro San Martín
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0224527 (2019)
Mitochondrial toxicity is a primary source of pre-clinical drug attrition, black box warning and post-market drug withdrawal. Methods that detect mitochondrial toxicity as early as possible during the drug development process are required. Here we in
Externí odkaz:
https://doaj.org/article/e8247fc886264cf385c2b4c679512465
Fluid Brain Glycolysis: Limits, Speed, Location, Moonlighting, and the Fates of Glycogen and Lactate
Autor:
Daniela Rauseo, Yasna Contreras-Baeza, Alejandro San Martín, Sharin Valdivia, Felipe Baeza-Lehnert, Alex Galaz, Pamela Y. Sandoval, Robinson Arce-Molina, L. Felipe Barros, Iván Ruminot
Publikováno v:
Neurochemical Research. 45:1328-1334
Glycolysis is the core of intermediate metabolism, an ancient pathway discovered in the heydays of classic biochemistry. A hundred years later, it remains a matter of active research, clinical interest and is not devoid of controversy. This review ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1a534e5f80c31b9019357eab2ae707
https://doi.org/10.1007/s11064-020-03005-2
https://doi.org/10.1007/s11064-020-03005-2
Publikováno v:
PLoS Genetics, Vol 11, Iss 7, p e1005405 (2015)
The intra-S phase checkpoint kinase of metazoa and yeast, ATR/MEC1, protects chromosomes from DNA damage and replication stress by phosphorylating subunits of the replicative helicase, MCM2-7. Here we describe an unprecedented ATR-dependent pathway i
Externí odkaz:
https://doaj.org/article/76a45235fbef452cadad97c4a052d0ce
Autor:
Miroslav Arambasic, Pamela Y Sandoval, Cristina Hoehener, Aditi Singh, Estienne C Swart, Mariusz Nowacki
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112899 (2014)
The epigenetic influence of maternal cells on the development of their progeny has long been studied in various eukaryotes. Multicellular organisms usually provide their zygotes not only with nutrients but also with functional elements required for p
Externí odkaz:
https://doaj.org/article/476a7867d368446db5514c148642377c
Autor:
Karin Alegría, Felipe Baeza-Lehnert, Alex Galaz, Yasna Contreras-Baeza, L. Felipe Barros, Iván Ruminot, Ignacio Fernández-Moncada, Alejandro San Martín, Francisca Cortés-Molina, Pamela Y. Sandoval, Robinson Arce-Molina
Publikováno v:
Journal of Neuroscience Research. 95:2267-2274
Recent articles have drawn renewed attention to the housekeeping glucose transporter GLUT1 and its possible involvement in neurodegenerative diseases. Here we provide an updated analysis of brain glucose transport and the cellular mechanisms involved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a507dc86aee11351b277f2a39fd9298
https://doi.org/10.1002/jnr.23998
https://doi.org/10.1002/jnr.23998
Autor:
Stefanie Schirmeier, Alex Galaz, L. F. Barros, Karin Alegría, Francisca Cortés-Molina, Pamela Y. Sandoval, Robinson Arce-Molina, Alejandro San Martín
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Mitochondria generate ATP and building blocks for cell growth and regeneration, using pyruvate as the main substrate. Here we introduce PyronicSF, a user-friendly GFP-based sensor of improved dynamic range that enables real-time subcellular quantitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e10b32c2654a5c667a5dcefe4ceaf9e9
https://doi.org/10.1101/611806
https://doi.org/10.1101/611806
Autor:
Francisca Cortés-Molina, A. A. San Martin, Pamela Y. Sandoval, Robinson Arce-Molina, Alex Galaz, Carlos A. Flores, Felipe Baeza-Lehnert, L. F. Barros, Karin Alegría, Anita Guequén, R. Alarcon, Yasna Contreras-Baeza
MCT4 is an H+-coupled transporter expressed in metastatic cancer cells, macrophages, and other highly glycolytic cells, where it extrudes excess lactate generated by the Warburg phenomenon or by hypoxia. Intriguingly, its reported Kmfor lactate, obta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02413feadd4cc344e6f1eed4ab90ee29