Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Pamela T. Wong"'
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)
Many pathogens enter the host through mucosal sites. Thus, interfering with pathogen entry through local neutralization at mucosal sites therefore is an effective strategy for preventing disease. Mucosally administered vaccines have the potential to
Externí odkaz:
https://doaj.org/article/e969c9cef631426caf580411f2c6955b
Autor:
Mohammad Farazuddin, Grant Acker, Joseph Zourob, Jessica J. O’Konek, Pamela T. Wong, Susan Morris, Andrew J. Rasky, Chang H. Kim, Nicholas W. Lukacs, James R. Baker, Jr.
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110103- (2024)
Summary: Retinoic acid (RA), controls the immunoregulatory functions of many immune cells, including dendritic cells (DCs), and is important for mucosal immunity. In DCs, RA regulates the expression of pattern recognition receptors and stimulates int
Externí odkaz:
https://doaj.org/article/55aa5bd1b6a845208fb6063fbe76ebbc
Autor:
Sonia Jangra, Jeffrey J. Landers, Gabriel Laghlali, Raveen Rathnasinghe, Prajakta Warang, Seok-Chan Park, Jessica. J. O’Konek, Gagandeep Singh, Katarzyna W. Janczak, Adolfo García-Sastre, Nandini Arya, Dilara Karadag, James R. Baker, Michael Schotsaert, Pamela T. Wong
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-18 (2023)
Abstract Multiple FDA-approved SARS-CoV-2 vaccines currently provide excellent protection against severe disease. Despite this, immunity can wane relatively fast, particularly in the elderly and novel viral variants capable of evading infection- and
Externí odkaz:
https://doaj.org/article/e0f2e171cb6d49a6bff9be7e335d5f23
Autor:
Kelly M. O’Shea, Charles F. Schuler, Jesse Chen, Jonathan P. Troost, Pamela T. Wong, Kelsea Chen, Daniel R. O’Shea, Westley Peng, Carmen Gherasim, David M. Manthei, Riccardo Valdez, James L. Baldwin, James R. Baker
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
ImportanceThe degree of immune protection against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants provided by infection versus vaccination with wild-type virus remains unresolved, which could influence future vaccine strategies.
Externí odkaz:
https://doaj.org/article/3cd9b377ce6b40d6b045e0b6603f2ae6
Autor:
Sonia Jangra, Jeffrey J. Landers, Raveen Rathnasinghe, Jessica J. O’Konek, Katarzyna W. Janczak, Marilia Cascalho, Andrew A. Kennedy, Andrew W. Tai, James R. Baker, Michael Schotsaert, Pamela T. Wong
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Several SARS-CoV-2 vaccines have received EUAs, but many issues remain unresolved, including duration of conferred immunity and breadth of cross-protection. Adjuvants that enhance and shape adaptive immune responses that confer broad protection again
Externí odkaz:
https://doaj.org/article/02e1fb5d10c442a983749ef606a66613
Autor:
Sathit Malawong, Saengrawee Thammawithan, Pawinee Sirithongsuk, Sakda Daduang, Sompong Klaynongsruang, Pamela T. Wong, Rina Patramanon
Publikováno v:
Antibiotics, Vol 10, Iss 7, p 839 (2021)
Melioidosis is an infectious disease caused by Gram-negative bacillus bacteria Burkholderia pseudomallei. Due to the emerging resistance of B. pseudomallei to antibiotics including ceftazidime (CAZ), the development of novel antibiotics and alternati
Externí odkaz:
https://doaj.org/article/33057963e12d4eb1a2fc15b3f6050620
Publikováno v:
Journal of Allergy and Clinical Immunology. 150:1-11
Recent events involving the global coronavirus pandemic have focused attention on vaccination strategies. Although tremendous advances have been made in subcutaneous and intramuscular vaccines during this time, one area that has lagged in implementat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dac9d55d1cc5dff294953cf9a8a6f83
https://doi.org/10.1016/j.jaci.2022.05.002
https://doi.org/10.1016/j.jaci.2022.05.002
Autor:
Jayme Cannon, Shengzhuang Tang, Jessica J. O’Konek, Pamela T. Wong, Racquel Harrison, Seok-Ki Choi, Kelly Yang, Matthew J. Ruge
Publikováno v:
ACS Applied Materials & Interfaces. 12:33500-33515
Here, we describe a nanoscale reactor strategy with a topical application in the therapeutic decontamination of reactive organophosphates (OPs) as chemical threat agents. It involves functionalization of poly(amidoamine) dendrimer through a combinati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfcecf7dc71261236b9f45701d29c5f2
https://doi.org/10.1021/acsami.0c08946
https://doi.org/10.1021/acsami.0c08946
Autor:
Pamela T. Wong, Megan E. Ermler, Jessica J. O’Konek, Rachel Sun, Peter H. Goff, Jeffrey J. Landers, Matthew J. Ruge, Alyssa Sebring, Katarzyna W. Janczak, Weina Sun, James R. Baker
Publikováno v:
Molecular Pharmaceutics. 18:679-698
Current influenza virus vaccines are focused on humoral immunity and are limited by the short duration of protection, narrow cross-strain efficacy, and suboptimal immunogenicity. Here, we combined two chemically and biologically distinct adjuvants, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56a6312ebbe4cb8428a6ecee2e15fb0
https://doi.org/10.1021/acs.molpharmaceut.0c00315
https://doi.org/10.1021/acs.molpharmaceut.0c00315
Autor:
Pamela T Wong, Pascale R Leroueil, Douglas M Smith, Susan Ciotti, Anna U Bielinska, Katarzyna W Janczak, Catherine H Mullen, Jeffrey V Groom, Erin M Taylor, Crystal Passmore, Paul E Makidon, Jessica J O'Konek, Andrzej Myc, Tarek Hamouda, James R Baker
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126120 (2015)
Vaccine adjuvants have been reported to induce both mucosal and systemic immunity when applied to mucosal surfaces and this dual response appears important for protection against certain pathogens. Despite the potential advantages, however, no mucosa
Externí odkaz:
https://doaj.org/article/4084c3c916ea48baa41149fcafb14c47