Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Pamela Stanley"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Identifying factors required for spermatogenesis is important for understanding mechanisms of male fertility. Inactivation of either the Mgat1 or Man2a2 gene leads to a block in spermatogenesis causing infertility in male mice. MGAT1 GlcNAc-transfera
Externí odkaz:
https://doaj.org/article/9ec1d3240e124406b8695ae46ae4042a
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Notch signaling determines cell fates in mouse intestine. Notch receptors contain multiple epidermal growth factor-like (EGF) repeats modified by O-glycans that regulate Notch signaling. Conditional deletion of protein O-fucosyltransferase 1
Externí odkaz:
https://doaj.org/article/d8906cd5bdb240128fc613928d1be229
Autor:
Ankit Tanwar, Pamela Stanley
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Glycosylation of Notch receptors by O-fucose glycans regulates Notch ligand binding and Notch signaling during hematopoiesis. However, roles in hematopoiesis for other O-glycans that modify Notch receptors have not been determined. Here we show that
Externí odkaz:
https://doaj.org/article/77dd25825d4f4b8f92fe1e5747869820
Autor:
Pamela Stanley, Ankit Tanwar
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Notch signaling via NOTCH1 stimulated by Delta-like ligand 4 (DLL4) is required for the development of T cells in thymus, and NOTCH2 stimulated by Notch ligand DLL1 is required for the development of marginal zone (MZ) B cells in spleen. Notch signal
Externí odkaz:
https://doaj.org/article/64a3829a32ac46a19ad3e9592540c462
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/8b229fb4dc2a45a8b46d54c64161be26
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
MGAT1 and complex N-glycans are required for spermatogenesis and fertility. Conditional deletion of Mgat1 in spermatogonia (Mgat1 cKO) causes reduced ERK1/2 signaling and the formation of multinucleated germ cells (MNC). Here we show that glycomics a
Externí odkaz:
https://doaj.org/article/c8cca026bdc743e5abd956d04cee5e92
Autor:
Yidong Wang, Bingruo Wu, Pengfei Lu, Donghong Zhang, Brian Wu, Shweta Varshney, Gonzalo del Monte-Nieto, Zhenwu Zhuang, Rabab Charafeddine, Adam H. Kramer, Nicolas E. Sibinga, Nikolaos G. Frangogiannis, Richard N. Kitsis, Ralf H. Adams, Kari Alitalo, David J. Sharp, Richard P. Harvey, Pamela Stanley, Bin Zhou
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Though coronary arteries are crucial for heart function, the mechanisms guiding their formation are largely unknown. Here, Wang et al. identify a unique, endocardially-derived angiogenic precursor cell population for coronary artery formation in mice
Externí odkaz:
https://doaj.org/article/ea93cbead9a042ce807dbd39e7d1c160
Autor:
Ayodele Akintayo, Pamela Stanley
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Glycosylation of proteins by N- and O-glycans or glycosaminoglycans (GAGs) mostly begins in the endoplasmic reticulum and is further orchestrated in the Golgi compartment via the action of >100 glycosyltransferases that reside in this complex organel
Externí odkaz:
https://doaj.org/article/18b49fee28034dc8868b29d951f3cfe1
Autor:
Shweta Varshney, Pamela Stanley
Publikováno v:
Bio-Protocol, Vol 7, Iss 23 (2017)
Notch signaling is an evolutionarily conserved signaling pathway that plays an indispensable role during development, and in the maintenance of homeostatic processes, in a wide variety of tissues (Kopan, 2012; Hori et al., 2013). The multifaceted rol
Externí odkaz:
https://doaj.org/article/5422733908be4caeb2fce599fb7e8629
Autor:
Shogo Sawaguchi, Shweta Varshney, Mitsutaka Ogawa, Yuta Sakaidani, Hirokazu Yagi, Kyosuke Takeshita, Toyoaki Murohara, Koichi Kato, Subha Sundaram, Pamela Stanley, Tetsuya Okajima
Publikováno v:
eLife, Vol 6 (2017)
The glycosyltransferase EOGT transfers O-GlcNAc to a consensus site in epidermal growth factor-like (EGF) repeats of a limited number of secreted and membrane proteins, including Notch receptors. In EOGT-deficient cells, the binding of DLL1 and DLL4,
Externí odkaz:
https://doaj.org/article/e7a1bc4833b74f98bf81aec85029f6d8