Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Pamela S. Gallagher"'
Autor:
Ligia A. Pinto, Ribhi M. Shawar, Brendan O’Leary, Troy J. Kemp, James Cherry, Natalie Thornburg, Cheryl N. Miller, Pamela S. Gallagher, Timothy Stenzel, Brittany Schuck, S. Michele Owen, Marina Kondratovich, Panayampalli S. Satheshkumar, Amy Schuh, Sandra Lester, M. Cristina Cassetti, Norman E. Sharpless, Steven Gitterman, Douglas R. Lowy
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 1 (2022)
ABSTRACT The emergence of SARS-CoV-2 created a crucial need for serology assays to detect anti-SARS-CoV-2 antibodies, which led to many serology assays entering the market. A trans-government collaboration was created in April 2020 to independently e
Externí odkaz:
https://doaj.org/article/fd1d888a005e451da19462a26970c706
Autor:
Lisa Rodriguez, Martha Donoghue, Soma Ghosh, Marc R. Theoret, Pamela S. Gallagher, Steven Lemery, Richard Pazdur, Julia A. Beaver, Lola Fashoyin-Aje, Mengdie Yuan, Leigh Marcus, Reena Philip
Publikováno v:
Clin Cancer Res
The FDA approved pembrolizumab on June 16, 2020, for the treatment of adult and pediatric patients with unresectable or metastatic tumor mutational burden–high [TMB-H; ≥10 mutations/megabase (mut/Mb)] solid tumors, as determined by an FDA-approve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e792816ef6948b0a466c7bd0f7131a
https://pubmed.ncbi.nlm.nih.gov/34083238
https://pubmed.ncbi.nlm.nih.gov/34083238
Autor:
Jothy Dhakshnamoorthy, Pamela S Gallagher, Hua Xiao, David C. Wheeler, Gobi Thillainadesan, Shiv I. S. Grewal, Madeline Larkin, Raghunath Chatterjee, Christopher Wellman, Vanivilasini Balachandran
Publikováno v:
Nature structural & molecular biology
Iron metabolism is critical for sustaining life and maintaining human health. Here, we find that iron homeostasis is linked to facultative heterochromatin assembly and regulation of gene expression during adaptive genome control. We show that the fis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9d41869529098d0e046f98412dc172
https://pubmed.ncbi.nlm.nih.gov/29686279
https://pubmed.ncbi.nlm.nih.gov/29686279
Autor:
Michelle L. Oeser, Richard G. Gardner, Daniel Kaganovich, Pamela S. Gallagher, Ayelet Chen Abraham
Publikováno v:
Cellular and Molecular Life Sciences. 71:1865-1879
The accumulation and aggregation of misfolded proteins is the primary hallmark for more than 45 human degenerative diseases. These devastating disorders include Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis. Over 15 degene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c7b65d22a4afd9679ee0f1af31fc47
https://doi.org/10.1007/s00018-013-1530-y
https://doi.org/10.1007/s00018-013-1530-y
Autor:
Richard G. Gardner, Claire J. Walker, Ngan Pham, Catherine A. Konopka, Pamela S. Gallagher, Melissa N. Locke, Michael P. Hart, Aaron D. Gitler
Publikováno v:
Molecular Biology of the Cell
Polyalanine expansions can result in aggregation and cause cytotoxicity. We have created the first yeast model of polyalanine-expansion aggregation and toxicity using the poly(Ade)-binding protein Pab1.
Nine human disorders result from the toxic
Nine human disorders result from the toxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aabae78f55d7abed0bdb4dba91f024b
https://doi.org/10.1091/mbc.e11-01-0037
https://doi.org/10.1091/mbc.e11-01-0037
Publikováno v:
Genes, Brain and Behavior. 6:389-400
Although mice with a targeted disruption of the serotonin transporter (SERT) have been studied extensively using various tests, their complex behavioral phenotype is not yet fully understood. Here we assess in detail the behavior of adult female SERT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b8ec95c781f51685f0c1083fac2819
https://doi.org/10.1111/j.1601-183x.2006.00270.x
https://doi.org/10.1111/j.1601-183x.2006.00270.x
Publikováno v:
NeuroReport. 17:1347-1351
Although the serotonin transporter is a key target for antidepressants, its exact role in depression etiology remains unclear. While serotonin transporter knockout mice are a potential model to examine this problem, their depression profile is unclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3e5066db24c41ad3f436fed5d8025d
https://doi.org/10.1097/01.wnr.0000230514.08962.76
https://doi.org/10.1097/01.wnr.0000230514.08962.76
Publikováno v:
Journal of Cell Science.
Cdc48/p97, also known as valosin-containing protein or VCP, is an abundant AAA-ATPase that is essential for many ubiquitin-dependent processes. One well-documented role for Cdc48 is facilitating the delivery of ubiquitinated, misfolded endoplasmic-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b416c1975f2c8bd6e41e043a63de5fa7
https://doi.org/10.1242/jcs.141838
https://doi.org/10.1242/jcs.141838
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ca2888ab7c98175f768290804dd55f6
https://doi.org/10.1096/fasebj.27.1_supplement.86.2
https://doi.org/10.1096/fasebj.27.1_supplement.86.2
Publikováno v:
The Journal of biological chemistry. 288(9)
Misfolded proteins present an escalating deleterious challenge to cells over the course of their lifetime. One mechanism the cell possesses to prevent misfolded protein accumulation is their destruction by protein quality control (PQC) degradation sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad7d0b059189e3c6f9746882bf0ed1e
https://pubmed.ncbi.nlm.nih.gov/23335508
https://pubmed.ncbi.nlm.nih.gov/23335508