Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Pamela S Shirley"'
Autor:
Pamela S Shirley, Cheng Cheng, Michele Kaloss, David A. Stewart, Paul L. Hallenbeck, Lynda K. Hawkins, Suzanne Forry-Schaudies, Carl M. Hay, P. Seshidhar Reddy, Anthony Marinov, John L. Jakubczak, Ying Huang, Patricia Ryan, Jingping Yang, Yelena Skripchenko, Lori Clarke, Ling Xu, Sandrina Phipps, Shanthi Ganesh
Publikováno v:
Cancer Gene Therapy. 11:555-569
A potentially promising treatment of metastatic cancer is the systemic delivery of oncolytic adenoviruses. This requires engineering viruses which selectively replicate in tumors. We have constructed such an oncolytic adenovirus, OAS403, in which two
Autor:
Michael Kaleko, Sheila Connelly, David Lillicrap, Cherie Cameron, Shawn Tinlin, Pamela S. Shirley, Angela M. Gallo-Penn, J. Andrews, Colleen Notley, Sandy Webster, Christine Hough
Publikováno v:
Blood. 97:107-113
Canine hemophilia A closely mimics the human disease and has been used previously in the development of factor VIII (FVIII) protein replacement products. FVIII-deficient dogs were studied to evaluate an in vivo gene therapy approach using an E1/E2a/E
Publikováno v:
Molecular Therapy. 2:223-232
While much is known about adenovirus biology from its development as a therapeutic gene delivery vehicle, an important question remains regarding the appropriate in vivo vector dose. We describe here an in vivo dose threshold effect with an adenovira
Publikováno v:
Scopus-Elsevier
Immunity to adenoviruses is an important hurdle to be overcome for successful gene therapy. The presence of antibodies to the capsid proteins prevents efficacious adenovirus vector administration in vivo. We tested whether immunity to a particular se
Autor:
Sheila Connelly, Colleen Notley, Cherie Cameron, Pamela S. Shirley, Michele Kaloss, Shawn Tinlin, J. Andrews, Angela M. Gallo-Penn, Anne Pinkstaff, David Lillicrap, Dawn B. Kayda, Michael Kaleko, Christine Hough
Publikováno v:
Human gene therapy. 10(11)
Hemophilia A is the most common severe hereditary coagulation disorder and is caused by a deficiency in blood clotting factor VIII (FVIII). Canine hemophilia A represents an excellent large animal model that closely mimicks the human disease. In prev
Autor:
Catherine C. Hedrick, Michael J. Thomas, Pamela S. Shirley, S. Smith, A. S. Willard, W. G. Jerome, Jian Pang
Publikováno v:
Journal of leukocyte biology. 51(6)
In this study, superoxide formation was not immediately detected when polymorphonuclear leukocytes were treated with linoleyl alcohol–coated, carboxy-modified latex beads. However, all other measures of neutrophil activation were present. Superoxid
Publikováno v:
The Journal of infectious diseases. 163(5)
Epstein-Barr virus (EBV) obtained directly from the oropharynx was used to detect viral DNA deleted for the EBV nuclear antigen 2 (EBNA2)-encoding gene that is essential for lymphocyte transformation. By polymerase chain reaction analysis, the deleti
Autor:
Charles E. McCall, Catherine M. Wilfert, Linda C. McPhail, Richard B. Johnston, Lawrence R. DeChatelet, Pamela S. Shirley
Publikováno v:
The Journal of Pediatrics. 90:213-217
NADPH oxidase activity was examined in paired 27,000×g granule fractions isolated from normal polymorphonuclear leukocytes and leukocytes from patients with chronic granulomatous disease. At 0.17 mM NADPH, the oxidase activity was not measurable in
Publikováno v:
Biochemical Medicine. 25:106-113
Although 20 m m fluoride stimulates neutrophils to produce superoxide anion, the kinetics of production are dissimilar to those observed with other stimuli. Further, fluoride was shown to inhibit oxidation of [1- 14 C] glucose, and incubation of neut
Publikováno v:
Blood. 49:445-454
Cyanide has been shown to stimulate both oxygen uptake and hexose monophosphate shunt activity in phagocytizing human polymorphonuclear leukocytes. It also stimulates the oxidation of NADPH by a particulate fraction derived from phagocytizing cells.