Zobrazeno 1 - 10
of 450
pro vyhledávání: '"Pamela S, Ohashi"'
Autor:
Weiyue Zheng, Wanda Marini, Kiichi Murakami, Valentin Sotov, Marcus Butler, Chiara Gorrini, Pamela S. Ohashi, Michael Reedijk
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Tumor immune microenvironment (TIME) spatial organization predicts outcome and therapy response in triple-negative breast cancer (TNBC). An immunosuppressive TIME containing elevated tumor-associated macrophages (TAM) and scarce CD8+ T cells
Externí odkaz:
https://doaj.org/article/4d346735c00b47528f142bed12cffe46
Autor:
Jessica A. Mathews, Dorota T. Borovsky, Kyle T. Reid, Julia M. Murphy, Sarah J. Colpitts, Abel Santos Carreira, Tommy Alfaro Moya, Douglas C. Chung, Igor Novitzky-Basso, Jonas Mattsson, Pamela S. Ohashi, Sarah Q. Crome
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111416- (2024)
Summary: Natural killer (NK) cell activity is influenced by cytokines and microenvironment factors, resulting in remarkably diverse functions, by contributing to inflammatory responses or serving as rheostats of adaptive immunity. Using single cell R
Externí odkaz:
https://doaj.org/article/2baf0f6025ed45cba21fb3b4c09ad125
Characterization of innate lymphoid cell subsets infiltrating melanoma and epithelial ovarian tumors
Autor:
Douglas C. Chung, Maryam Ghaedi, Kathrin Warner, Azin Sayad, Samuel D. Saibil, Marcus Q. Bernardini, Blaise A. Clarke, Patricia A. Shaw, Marcus O. Butler, Alexandra Easson, Sorana Morrissy, Ben X. Wang, Linh Nguyen, Pamela S. Ohashi, Nicolas Jacquelot
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
The innate lymphoid cell (ILC) family is composed of heterogeneous innate effector and helper immune cells that preferentially reside in tissues where they promote tissue homeostasis. In cancer, they have been implicated in driving both pro- and anti
Externí odkaz:
https://doaj.org/article/2c98b09b40254ed59e8229b8fbac0c31
Autor:
Scott C. Lien, Dalam Ly, S. Y. Cindy Yang, Ben X. Wang, Derek L. Clouthier, Michael St. Paul, Ramy Gadalla, Babak Noamani, Carlos R. Garcia-Batres, Sarah Boross-Harmer, Philippe L. Bedard, Trevor J. Pugh, Anna Spreafico, Naoto Hirano, Albiruni R. A. Razak, Pamela S. Ohashi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Immunotherapies targeting PD-1/PD-L1 are now widely used in the clinic to treat a variety of malignancies. While most of the research on T cell exhaustion and PD-1 blockade has been focused on conventional αβ T cells, the contribution of i
Externí odkaz:
https://doaj.org/article/fd59752fa86742a8a6eab34aa0b37b3b
Autor:
S. Y. Cindy Yang, Scott C. Lien, Ben X. Wang, Derek L. Clouthier, Youstina Hanna, Iulia Cirlan, Kelsey Zhu, Jeffrey P. Bruce, Samah El Ghamrasni, Marco A. J. Iafolla, Marc Oliva, Aaron R. Hansen, Anna Spreafico, Philippe L. Bedard, Stephanie Lheureux, Albiruni Razak, Vanessa Speers, Hal K. Berman, Alexey Aleshin, Benjamin Haibe-Kains, David G. Brooks, Tracy L. McGaha, Marcus O. Butler, Scott V. Bratman, Pamela S. Ohashi, Lillian L. Siu, Trevor J. Pugh
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Although circulating tumour DNA (ctDNA) can predict immune checkpoint blockade (ICB) responses, its association with tumour biomarkers remains unknown. Here, the authors use ctDNA to inform exome and transcriptome profiling of >100 patients with 30 c
Externí odkaz:
https://doaj.org/article/2a55653c8f4a4ed888f461e4bdb5696f
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Innate and adaptive immune cells monitor, recognize, and eliminate transformed cells. Innate lymphoid cells (ILCs) are innate counterparts of T cells that play a key role in many facets of the immune response and have a profound impact on disease sta
Externí odkaz:
https://doaj.org/article/5ec8eee315cd489089d04a7b7cb7bafd
Autor:
John Wright, Stephanie Lheureux, Ilaria Colombo, Ramy Gadalla, Pamela S Ohashi, Xuan Li, Lisa Wang, Matthew S Block, David G Brooks, Andrea Jewell, Carolyn McCourt, Eugenia Girda, Sarah Temkin, Gini F Fleming, Linda Duska, Daniela E Matei, Panagiotis A Konstantinopoulos, Ben X Wang, Stephanie L Gaillard, Michael McHale, Floor J Backes, Theresa L Werner, Siobhan Kehoe, Rachel Wildman, Shirin Soleimani, Scott Lien, Trevor Pugh
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Combining immunotherapy and antiangiogenic agents is a promising treatment strategy in endometrial cancer. To date, no biomarkers for response have been identified and data on post-immunotherapy progression are lacking. We explored the com
Externí odkaz:
https://doaj.org/article/0e5bfe1cd7414e458e3cfe2d6fbf3f50
Autor:
Linh T. Nguyen, Charlotte S. Lo, Michael Fyrsta, Jessica Nie, Jennifer Y. Yam, Pei-Hua Yen, Michael X. Le, Karen Hersey, Miran Kenk, Megan Crumbaker, Neil Fleshner, Girish Kulkarni, Robert Hamilton, Michael Jewett, Antonio Finelli, Andrew Evans, Joan Sweet, Pamela S. Ohashi, Anthony M. Joshua
Publikováno v:
Prostate Cancer, Vol 2022 (2022)
Background. The evaluation of tumour-infiltrating lymphocytes (TILs) in solid malignancies has yielded insights into immune regulation within the tumour microenvironment and has also led to the development and optimisation of adoptive T cell therapie
Externí odkaz:
https://doaj.org/article/c4ca7626d4f24677b4e9214d25a6de45
Autor:
Heather L. MacGregor, Azin Sayad, Andrew Elia, Ben X. Wang, Sarah Rachel Katz, Patricia A. Shaw, Blaise A. Clarke, Sarah Q. Crome, Celine Robert-Tissot, Marcus Q. Bernardini, Linh T. Nguyen, Pamela S. Ohashi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-17 (2019)
Abstract Background B7-H3 and B7-H4 are highly expressed by many human malignancies making them attractive immunotherapeutic targets. However, their expression patterns and immune contexts in epithelial ovarian cancer have not been well characterized
Externí odkaz:
https://doaj.org/article/94955eb75206441b879db80277b112a6
Autor:
Derek L. Clouthier, Scott C. Lien, S. Y. Cindy Yang, Linh T. Nguyen, Venkata S. K. Manem, Diana Gray, Michael Ryczko, Albiruni R. A. Razak, Jeremy Lewin, Stephanie Lheureux, Ilaria Colombo, Philippe L. Bedard, David Cescon, Anna Spreafico, Marcus O. Butler, Aaron R. Hansen, Raymond W. Jang, Sangeet Ghai, Ilan Weinreb, Valentin Sotov, Ramy Gadalla, Babak Noamani, Mengdi Guo, Sawako Elston, Amanda Giesler, Sevan Hakgor, Haiyan Jiang, Tracy McGaha, David G. Brooks, Benjamin Haibe-Kains, Trevor J. Pugh, Pamela S. Ohashi, Lillian L. Siu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract Background Immune checkpoint inhibitors (ICIs) demonstrate unprecedented efficacy in multiple malignancies; however, the mechanisms of sensitivity and resistance are poorly understood and predictive biomarkers are scarce. INSPIRE is a phase
Externí odkaz:
https://doaj.org/article/31ba8dd2f028423db6db252c1c7723fb