Meta-analyses identify DNA methylation associated with kidney function and damage

Autor: Pascal Schlosser, Adrienne Tin, Pamela R. Matias-Garcia, Chris H. L. Thio, Roby Joehanes, Hongbo Liu, Antoine Weihs, Zhi Yu, Anselm Hoppmann, Franziska Grundner-Culemann, Josine L. Min, Adebowale A. Adeyemo, Charles Agyemang, Johan Ärnlöv, Nasir A. Aziz, Andrea Baccarelli, Murielle Bochud, Hermann Brenner, Monique M. B. Breteler, Cristian Carmeli, Layal Chaker, John C. Chambers, Shelley A. Cole, Josef Coresh, Tanguy Corre, Adolfo Correa, Simon R. Cox, Niek de Klein, Graciela E. Delgado, Arce Domingo-Relloso, Kai-Uwe Eckardt, Arif B. Ekici, Karlhans Endlich, Kathryn L. Evans, James S. Floyd, Myriam Fornage, Lude Franke, Eliza Fraszczyk, Xu Gao, Xīn Gào, Mohsen Ghanbari, Sahar Ghasemi, Christian Gieger, Philip Greenland, Megan L. Grove, Sarah E. Harris, Gibran Hemani, Peter Henneman, Christian Herder, Steve Horvath, Lifang Hou, Mikko A. Hurme, Shih-Jen Hwang, Marjo-Riitta Jarvelin, Sharon L. R. Kardia, Silva Kasela, Marcus E. Kleber, Wolfgang Koenig, Jaspal S. Kooner, Holly Kramer, Florian Kronenberg, Brigitte Kühnel, Terho Lehtimäki, Lars Lind, Dan Liu, Yongmei Liu, Donald M. Lloyd-Jones, Kurt Lohman, Stefan Lorkowski, Ake T. Lu, Riccardo E. Marioni, Winfried März, Daniel L. McCartney, Karlijn A. C. Meeks, Lili Milani, Pashupati P. Mishra, Matthias Nauck, Ana Navas-Acien, Christoph Nowak, Annette Peters, Holger Prokisch, Bruce M. Psaty, Olli T. Raitakari, Scott M. Ratliff, Alex P. Reiner, Sylvia E. Rosas, Ben Schöttker, Joel Schwartz, Sanaz Sedaghat, Jennifer A. Smith, Nona Sotoodehnia, Hannah R. Stocker, Silvia Stringhini, Johan Sundström, Brenton R. Swenson, Maria Tellez-Plaza, Joyce B. J. van Meurs, Jana V. van Vliet-Ostaptchouk, Andrea Venema, Niek Verweij, Rosie M. Walker, Matthias Wielscher, Juliane Winkelmann, Bruce H. R. Wolffenbuttel, Wei Zhao, Yinan Zheng, Estonian Biobank Research Team, Genetics of DNA Methylation Consortium, Marie Loh, Harold Snieder, Daniel Levy, Melanie Waldenberger, Katalin Susztak, Anna Köttgen, Alexander Teumer

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Many genetic loci have been identified to be associated with kidney disease, but the molecular mechanisms are not well understood. Here, the authors perform epigenome-wide association studies on kidney function measures to identify epigenetic marks a

Externí odkaz: https://doaj.org/article/0d948668b1d0481ab5f9d661584f9e5e

Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets

Autor: Xiaoguang Xu, Chachrit Khunsriraksakul, James M. Eales, Sebastien Rubin, David Scannali, Sushant Saluja, David Talavera, Havell Markus, Lida Wang, Maciej Drzal, Akhlaq Maan, Abigail C. Lay, Priscilla R. Prestes, Jeniece Regan, Avantika R. Diwadkar, Matthew Denniff, Grzegorz Rempega, Jakub Ryszawy, Robert Król, John P. Dormer, Monika Szulinska, Marta Walczak, Andrzej Antczak, Pamela R. Matías-García, Melanie Waldenberger, Adrian S. Woolf, Bernard Keavney, Ewa Zukowska-Szczechowska, Wojciech Wystrychowski, Joanna Zywiec, Pawel Bogdanski, A. H. Jan Danser, Nilesh J. Samani, Tomasz J. Guzik, Andrew P. Morris, Dajiang J. Liu, Fadi J. Charchar, Human Kidney Tissue Resource Study Group, Maciej Tomaszewski

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-29 (2024)

Abstract Genetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-specific epigenomic annotations and 3D genome information we generated and validated gene expression prediction models for the purpose of transcriptome-

Externí odkaz: https://doaj.org/article/f5e9da19c88d4024b4071ce5130ced06

Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

Autor: Jacob K. Kresovich, Jerome I. Rotter, James S. Pankow, Laura M. Raffield, André G. Uitterlinden, Hemant K. Tiwari, Dorret I. Boomsma, Marguerite R. Irvin, Kaare Christensen, Lili Milani, Jonas Mengel-From, Scott M. Ratliff, Peter Durda, James G. Wilson, Xiaochuan Wang, Rui Xia, Jordana T. Bell, Jenny van Dongen, Pamela R. Matias-Garcia, Alexander P. Reiner, Andrew M. McIntosh, Toshiko Tanaka, Sharon L.R. Kardia, Rebecca C Richmond, Konstantin Strauch, Rosie M. Walker, Dale P. Sandler, Amit Patki, Teemu Palviainen, Wei Chen, Pei-Chien Tsai, Medea Imboden, Stefania Bandinelli, Mika Kähönen, Xiuqing Guo, Stephen S. Rich, Oliver Robinson, Riccardo E. Marioni, Jie Yao, Debbie A Lawlor, Pierre Antoine Dugué, Roger L. Milne, Yunzhang Wang, Jennifer A. Smith, Nancy L. Pedersen, Matthijs D. van der Zee, Pashupati P. Mishra, Pei-Lun Kuo, Steve Horvath, Miina Ollikainen, Massimo Mangino, Melissa C. Southey, Ayoung Jeong, Linda Broer, Dianjianyi Sun, Tom G. Richardson, David Van Den Berg, Jack A. Taylor, Beate Ritz, Jeesun Jung, Caroline L Relton, Sarah E. Harris, Josine L. Min, Caroline Hayward, Eric Boerwinkle, Jaakko Kaprio, Melanie Waldenberger, David J. Porteous, Seyma Katrinli, Gibran Hemani, Olli T. Raitakari, Paolo Vineis, Silvia Polidoro, Karen N. Conneely, Christian Gieger, Donna K. Arnett, Marianne Nygaard, Maria K. Sobczyk, Therese Tillin, Falk W. Lohoff, Adolfo Correa, Wei Zhao, Elina Sillanpää, Zongli Xu, Joanne M. Murabito, John Wright, Gail Davies, Sara Hägg, Mette Soerensen, Alexandra M. Binder, Ann Zenobia Moore, Eco J. C. de Geus, Terho Lehtimäki, Dan Mason, Daniel L. McCartney, Myriam Fornage, Ian J. Deary, Alicia K. Smith, Joyce B. J. van Meurs, Ake T. Lu, Hannah R Elliott, Annette Peters, Silva Kasela, Idil Yet, Luigi Ferrucci, Shengxu Li, Nicole Probst-Hensch, Paul Elliott, Kathryn L. Lunetta

Publikováno v: Genome Biology, Vol 22, Iss 1, Pp 1-25 (2021)
Genome Biology
Mccartney, D L, Min, J L, Richmond, R C, Lu, A T, Sobczyk, M K, Davies, G, Broer, L, Guo, X, Jeong, A, Jung, J, Kasela, S, Katrinli, S, Kuo, P, Matias-garcia, P R, Mishra, P P, Nygaard, M, Palviainen, T, Patki, A, Raffield, L M, Ratliff, S M, Richardson, T G, Robinson, O, Soerensen, M, Sun, D, Tsai, P, Van Der Zee, M D, Walker, R M, Wang, X, Wang, Y, Xia, R, Xu, Z, Yao, J, Zhao, W, Correa, A, Boerwinkle, E, Dugué, P, Durda, P, Elliott, H R, Gieger, C, De Geus, E J C, Harris, S E, Hemani, G, Imboden, M, Kähönen, M, Kardia, S L R, Kresovich, J K, Li, S, Lunetta, K L, Mangino, M, Mason, D, Mcintosh, A M, Mengel-from, J, Moore, A Z, Murabito, J M, Ollikainen, M, Pankow, J S, Pedersen, N L, Peters, A, Polidoro, S, Porteous, D J, Raitakari, O, Rich, S S, Sandler, D P, Sillanpää, E, Smith, A K, Southey, M C, Strauch, K, Tiwari, H, Tanaka, T, Tillin, T, Uitterlinden, A G, Van Den Berg, D J, Van Dongen, J, Wilson, J G, Wright, J, Yet, I, Arnett, D, Bandinelli, S, Bell, J T, Binder, A M, Boomsma, D I, Chen, W, Christensen, K, Conneely, K N, Elliott, P, Ferrucci, L, Fornage, M, Hägg, S, Hayward, C, Irvin, M, Kaprio, J, Lawlor, D A, Lehtimäki, T, Lohoff, F W, Milani, L, Milne, R L, Probst-hensch, N, Reiner, A P, Ritz, B, Rotter, J I, Smith, J A, Taylor, J A, Van Meurs, J B J, Vineis, P, Waldenberger, M, Deary, I J, Relton, C L, Horvath, S & Marioni, R E 2021, ' Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging ', Genome Biology, vol. 22, no. 1 . https://doi.org/10.1186/s13059-021-02398-9
McCartney, D L, Min, J L, Richmond, R C, Lu, A T, Sobczyk, M K, Davies, G, Broer, L, Guo, X, Jeong, A, Jung, J, Kasela, S, Katrinli, S, Kuo, P L, Matias-Garcia, P R, Mishra, P P, Nygaard, M, Palviainen, T, Patki, A, Raffield, L M, Ratliff, S M, Richardson, T G, Robinson, O, Soerensen, M, Sun, D, Tsai, P C, van der Zee, M D, Walker, R M, Wang, X, Wang, Y, Xia, R, Xu, Z, Yao, J, Zhao, W, Correa, A, Boerwinkle, E, Dugué, P A, Durda, P, Elliott, H R, Gieger, C, de Geus, E J C, Harris, S E, Hemani, G, Imboden, M, Kähönen, M, Kardia, S L R, Kresovich, J K, Li, S, Lunetta, K L, Mengel-From, J, Christensen, K, The Genetics of DNA Methylation Consortium & NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium 2021, ' Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging ', Genome Biology, vol. 22, 194 . https://doi.org/10.1186/s13059-021-02398-9
McCartney, D L, van der Zee, M D, de Geus, E J C, van Dongen, J, Boomsma, D I, Marioni, R E, The Genetics of DNA Methylation Consortium & NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium 2021, ' Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging ', Genome Biology, vol. 22, no. 1, 194, pp. 1-25 . https://doi.org/10.1186/s13059-021-02398-9
Genome Biol. 22:194 (2021)
McCartney, D L, Min, J L, Richmond, R C, Lu, A T, Sobczyk, M K, Davies, G, Broer, L, Guo, X, Jeong, A, Jung, J, Kasela, S, Katrinli, S, Kuo, P-L, Matias-Garcia, P R, Mishra, P P, Nygaard, M, Palviainen, T, Patki, A, Raffield, L M, Ratliff, S M, Richardson, T G, Robinson, O, Soerensen, M, Sun, D, Tsai, P-C, van der Zee, M D, Walker, R M, Wang, X, Wang, Y, Xia, R, Xu, Z, Yao, J, Zhao, W, Correa, A, Boerwinkle, E, Dugué, P-A, Durda, P, Elliott, H R, Gieger, C, de Geus, E J C, Harris, S E, Hemani, G, Smith, A K, Wright, J, Lawlor, D A, Relton, C L, Horvath, S & Marioni, R E & et, A 2021, ' Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging ', Genome Biology, vol. 22, no. 1, 194, pp. 194 . https://doi.org/10.1186/s13059-021-02398-9
Genome Biology, 22(1):194. BioMed Central Ltd.
Genome Biology, 22(1):194, 1-25. Springer Verlag

Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in population

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4c22aaef8ad6a80ac07f88cd86c101
https://trepo.tuni.fi/handle/10024/133417

Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline

Autor: Lukas Habegger, Charumathi Sabanayagam, Michael Preuss, Laura M. Raffield, Mary F. Feitosa, Bamidele O. Tayo, Kevin Ho, Leo-Pekka Lyytikäinen, Florian Kronenberg, Valencia Hui Xian Foo, Adrienne Tin, Michael Cantor, Nisha Bansal, Tarunveer S. Ahluwalia, Melanie Waldenberger, Sarah A. Pendergrass, Behrooz Z. Alizadeh, Wolfgang Koenig, Qiong Yang, Xiaodong Bai, Christoph Wanner, Ben Schöttker, Giovanni Coppola, A. R. Shuldiner, Leslie A. Lange, Piyush Gampawar, Markus Scholz, Tien Yin Wong, Mary L. Biggs, Morris Swertz, Alicia Hawes, Girish N. Nadkarni, Christina-Alexandra Schulz, Chiea Chuen Khor, Ricardo H. Ulloa, Jeffrey C. Staples, Miao-Li Chee, Laura M. Yerges-Armstrong, Andrew Blumenfeld, Karlhans Endlich, Bernhard Banas, Bruce H.R. Wolffenbuttel, Kai-Uwe Eckardt, Pavel Hamet, Carsten A. Böger, Harold Snieder, Marcus B. Jones, Judy Wang, Shih-Jen Hwang, Mathias Gorski, Anselm Hoppmann, Josyf C. Mychaleckyj, Bernd Holleczek, Pamela R. Matias-Garcia, Rainer Rettig, Karsten B. Sieber, Manasi Pradhan, Pashupati P. Mishra, Peter Rossing, Matthias Wuttke, Miao-Ling Chee, H. Marike Boezen, Yong Li, M. Arfan Ikram, Jeffrey G. Reid, Teresa Nutile, Maria Sotiropoulos Padilla, Lude Franke, Robert J. Carroll, Luca A. Lotta, Bernhard K. Krämer, Kjell Nikus, Jerome I. Rotter, Thomas Meitinger, Lars Wallentin, Cisca Wijmenga, Kent D. Taylor, Holly Kramer, Louis Widom, Olli T. Raitakari, Marcus E. Kleber, Man Li, Nina Hutri-Kähönen, Massimiliano Cocca, Reinhold Schmidt, John D. Overton, Cristian Pattaro, Michael Lattari, Sarah E. Wolf, Jin-Fang Chai, Karina Toledo, Brigitte Kühnel, Zhenhua Gu, Peter Almgren, Caitlin Forsythe, Yuri Milaneschi, Stephan J. L. Bakker, Layal Chaker, Dawn M. Waterworth, Silke Szymczak, James G. Wilson, Peter J. van der Most, Michelle L. O'Donoghue, William Salerno, Masayuki Yasuda, Sahar Ghasemi, Eric Boerwinkle, Josef Coresh, Ilja M. Nolte, Kia Manoochehri, Konstantin Strauch, Thomas D. Schleicher, Myriam Rheinberger, Audrey Y. Chu, Sanaz Sedaghat, Sandra Freitag-Wolf, Boting Ning, Matthias Nauck, Christina Beechert, Helena Schmidt, Harvey D. White, Nina Mononen, Johanne Tremblay, Navya Shilpa Josyula, Mika Kähönen, Katrin Horn, Andre Franke, Marianne Rots, Bettina Jung, Alexander R. Rosenkranz, Christian M. Shaffer, Mary Ann Lukas, Gerjan Navis, Christian Gieger, John Chalmers, Shareef Khalid, Uwe Völker, Marju Orho-Melander, Iris M. Heid, Brenda W.J.H. Penninx, A. Baras, Alexander Lopez, Evan Maxwell, Ruth J. F. Loos, Erin D. Fuller, Christa Meisinger, Gonçalo R. Abecasis, Suganthi Balasubramanian, Chris H. L. Thio, Martin H. de Borst, Stefan Coassin, Ching-Yu Cheng, Wolfgang Lieb, Kenneth Rice, Alexander Teumer, Mark Woodward, Gisu Eom, Hermann Brenner, Thomas W. Winkler, Anna Köttgen, Edith Hofer, Aris Economides, Ron T. Gansevoort, Pim van der Harst, Lyndon J. Mitnaul, Bruce M. Psaty, Erwin P. Bottinger, Olle Melander, Niek Verweij, Frauke Degenhardt, Yan Zhang, Mohsen Ghanbari, Veronika Wanner, Terho Lehtimäki, Leland Barnard

Publikováno v: Gorski, M, Jung, B, Li, Y, Matias-Garcia, P R, Wuttke, M, Coassin, S, Thio, C H L, Kleber, M E, Winkler, T W, Wanner, V, Chai, J-F, Chu, A Y, Cocca, M, Feitosa, M F, Ghasemi, S, Hoppmann, A, Horn, K, Li, M, Nutile, T, Scholz, M, Sieber, K B, Teumer, A, Tin, A, Wang, J, Tayo, B O, Ahluwalia, T S, Almgren, P, Bakker, S J L, Banas, B, Bansal, N, Biggs, M L, Boerwinkle, E, Bottinger, E P, Brenner, H, Carroll, R J, Chalmers, J, Chee, M-L, Chee, M-L, Cheng, C-Y, Coresh, J, de Borst, M H, Degenhardt, F, Eckardt, K-U, Endlich, K, Franke, A, Freitag-Wolf, S, Gampawar, P, Gansevoort, R T, Loos, R J F, Rossing, P & LifeLines Cohort Study 2021, ' Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline ', Kidney International, vol. 99, no. 4, pp. 926-939 . https://doi.org/10.1016/j.kint.2020.09.030
Kidney international (2020). doi:10.1016/j.kint.2020.09.030
info:cnr-pdr/source/autori:Mathias Gorski et al/titolo:Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline/doi:10.1016%2Fj.kint.2020.09.030/rivista:Kidney international/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume
Kidney International
Lifelines Cohort Study & Regeneron Genetics Center 2021, ' Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline ', Kidney International, vol. 99, no. 4, pp. 926-939 . https://doi.org/10.1016/j.kint.2020.09.030
Kidney International, 99(4), 926-939. ELSEVIER SCIENCE INC
Kidney International, 99(4), 926-939. Elsevier Inc.
Kidney International, 99(4), 926-939. Nature Publishing Group

Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To hel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe030174e9e300043a2bda6960bc9c1
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-430992

Epigenome-wide association study of dietary fatty acid intake

Autor: Julia Lange de Luna, Aayah Nounu, Sonja Neumeyer, Lucy Sinke, Rory Wilson, Fabian Hellbach, Pamela R. Matías-García, Thomas Delerue, Juliane Winkelmann, Annette Peters, Barbara Thorand, Marian Beekman, Bastiaan T. Heijmans, Eline Slagboom, Christian Gieger, Jakob Linseisen, Melanie Waldenberger

Publikováno v: Clinical Epigenetics, Vol 16, Iss 1, Pp 1-11 (2024)

Abstract Background Dietary intake of n-3 polyunsaturated fatty acids (PUFA) may have a protective effect on the development of cardiovascular diseases, diabetes, depression and cancer, while a high intake of n-6 PUFA was often reported to be associa

Externí odkaz: https://doaj.org/article/0c2d8b5f2bb94eac9bcb5c4861efb66f