Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Pamela Pulimeno"'
Autor:
Sapna Puri, Hasna Maachi, Gopika Nair, Holger A. Russ, Richard Chen, Pamela Pulimeno, Zachary Cutts, Vasilis Ntranos, Matthias Hebrok
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Despite significant research, mechanisms underlying the failure of islet beta cells that result in type 2 diabetes (T2D) are still under investigation. Here, we report that Sox9, a transcriptional regulator of pancreas development, also func
Externí odkaz:
https://doaj.org/article/78e918df306c49569dad84919d98da27
Autor:
Laurent Perrin, Ursula Loizides-Mangold, Svetlana Skarupelova, Pamela Pulimeno, Stephanie Chanon, Maud Robert, Karim Bouzakri, Christine Modoux, Pascale Roux-Lombard, Hubert Vidal, Etienne Lefai, Charna Dibner
Publikováno v:
Molecular Metabolism, Vol 4, Iss 11, Pp 834-845 (2015)
Objective: Circadian clocks are functional in all light-sensitive organisms, allowing an adaptation to the external world in anticipation of daily environmental changes. In view of the potential role of the skeletal muscle clock in the regulation of
Externí odkaz:
https://doaj.org/article/ba28d724dfba4a4ea475df3749c20b87
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12207 (2010)
The pleckstrin-homology-domain-containing protein PLEKHA7 was recently identified as a protein linking the E-cadherin-p120 ctn complex to the microtubule cytoskeleton. Here we characterize the expression, tissue distribution and subcellular localizat
Externí odkaz:
https://doaj.org/article/77c2b89145c24dae899881f4474bc47f
Autor:
Carmen Mota Reyes, Maximilian Kiessler, Pino Bordignon, Samuel Aubert, Pamela Pulimeno, Helmut Friess, Rouzanna Istvanffy, Ihsan Ekin Demir
Publikováno v:
Cancer Research. 83:2254-2254
Pancreatic cancer is one of the most common cancers worldwide and its incidence is increasing globally. Treatment consists of surgical resection followed by adjuvant or neoadjuvant therapy. Neoadjuvant therapy (neoTx) has dramatically improved the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60111b726d5444fd68daa9d9f703b385
https://doi.org/10.1158/1538-7445.am2023-2254
https://doi.org/10.1158/1538-7445.am2023-2254
Autor:
J. Wade Harper, Pamela Pulimeno, Shane D. Elliott, Laura Pontano Vaites, Zon Weng Lai, Tobias C. Walther, Robert V. Farese, Christina B. K. Jayson, Joao A. Paulo, Katlyn R. Gabriel, Sebastian Boland, Jonathan S. Weissman, Chandramohan Chitraju, Laura M. Bond, Manuele Piccolis, Martin Kampmann
Publikováno v:
Mol Cell
Excessive levels of saturated fatty acids are toxic to cells, although the basis for this lipotoxicity remains incompletely understood. Here, we analyzed the transcriptome, lipidome, and genetic interactions of human leukemia cells exposed to palmita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9b9ca8518fefe65935271fd599cd3a
https://europepmc.org/articles/PMC7696670/
https://europepmc.org/articles/PMC7696670/
Autor:
Camille Saini, Volodymyr Petrenko, Thierry Berney, Cédric Howald, Matthias Hebrok, Pamela Pulimeno, Emmanouil T. Dermitzakis, Charna Dibner, Laurianne Giovannoni
Publikováno v:
Diabetes Obesity Metabolism
Diabetes, Obesity and Metabolism, Vol. 18, No 4 (2016) pp. 355-65
Diabetes, Obesity and Metabolism, Vol. 18, No 4 (2016) pp. 355-65
Aim To determine the impact of a functional human islet clock on insulin secretion and gene transcription. Methods Efficient circadian clock disruption was achieved in human pancreatic islet cells by small interfering RNA mediated knockdown of CLOCK.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0851b60d94bfe566dca9b59c66f0514
https://doi.org/10.1111/dom.12616
https://doi.org/10.1111/dom.12616
Autor:
Tushar Patel, Antonis Kourtidis, Ryan W. Feathers, E. Aubrey Thompson, Edith A. Perez, Pamela Pulimeno, John A. Copland, Lomeli R. Carpio, Siu P. Ngok, Panagiotis Z. Anastasiadis, Peter Storz, Sandra Citi, Jennifer M. Carr, Sahra Borges, Tiany R. Baker, Irene K. Yan
Publikováno v:
Nature Cell Biology. 17:1145-1157
E-cadherin and p120 catenin (p120) are essential for epithelial homeostasis, but can also exert pro-tumorigenic activities. Here, we resolve this apparent paradox by identifying two spatially and functionally distinct junctional complexes in non-tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4021888a4143a734753fdf7c413657
https://doi.org/10.1038/ncb3227
https://doi.org/10.1038/ncb3227
Publikováno v:
Annals of the New York Academy of Sciences. 1257:125-132
Cingulin, paracingulin, and PLEKHA7 are proteins localized in the cytoplasmic region of the apical junctional complex of vertebrate epithelial cells. Cingulin has been detected at tight junctions (TJs), whereas paracingulin has been detected at both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16e76643bea9cedbb9607c513d5cacd4
https://doi.org/10.1111/j.1749-6632.2012.06506.x
https://doi.org/10.1111/j.1749-6632.2012.06506.x
Publikováno v:
The Journal of biological chemistry
Paracingulin is a 160-kDa protein localized in the cytoplasmic region of epithelial tight and adherens junctions, where it regulates RhoA and Rac1 activities by interacting with guanine nucleotide exchange factors. Here, we investigate the molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba71742db0d33e815bfae04f5787594
Publikováno v:
Molecular membrane biology
Small GTPases of the Rho family (RhoA, Rac1, and Cdc42) and the Ras family GTPase Rap1 are essential for the assembly and function of epithelial cell-cell junctions. Through their downstream effectors, small GTPases modulate junction formation and st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006b58ec65f0c598e41085e75415f66d