Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Pamela N. Pharr"'
Autor:
Jerry L. Spivak, Stephen T. Sawyer, Teresa A. Zimmers, W. David Hankins, Jacalyn H. Pierce, Pamela N. Pharr, Alan N. Schechter, Sandra K. Ruscetti, Donna M. Williams
Publikováno v:
Annals of the New York Academy of Sciences. 718:232-244
Autor:
Demetri D. Spyropoulos, Makio Ogawa, Dennis K. Watson, Tatsuya Ito, Hiroshi Kawada, Pamela N. Pharr
Publikováno v:
International Journal of Hematology. 73:463-468
Mouse embryos homozygous for a targeted disruption in the Fli-1 gene show hemorrhage into the neural tube and brain on embryonic day (E)11.0 and die shortly thereafter. Livers from the mutant embryos contain drastically reduced numbers of pronormobla
Autor:
Pamela N. Pharr, Liza Thomas, Kathleen D. Liu, Yun You, Gregory D. Longmore, Aki Mikami, Mark A. Goldsmith
Publikováno v:
Proceedings of the National Academy of Sciences. 95:7006-7011
Erythropoietin (EPO) is required for red blood cell development, but whether EPO-specific signals directly instruct erythroid differentiation is unknown. We used a dominant system in which constitutively active variants of the EPO receptor were intro
Autor:
Aki Mikami, Kathleen D. Liu, Jaime Molden, Stephen Y. Lai, Yun You, Pamela N. Pharr, Mark A. Goldsmith, Gregory D. Longmore
Publikováno v:
Blood. 91:870-878
Cytokine receptors have been shown in cell culture systems to use phosphotyrosine residues as docking sites for certain signal transduction intermediates. Studies using various cellular backgrounds have yielded conflicting information about the impor
Publikováno v:
Blood. 82:2386-2395
Increasing direct and indirect evidence suggests that erythropoietin (Epo) promotes both erythropoiesis and megakaryocytopoiesis. Here we report that, in mice infected with a recombinant spleen focus-forming retrovirus (SFFV) expressing an oncogenic
Autor:
Ruth A. Busche, Stephanie S. Watowich, Xiaoling Xie, Pamela N. Pharr, Aki Mikami, Gregory D. Longmore
Erythropoietin (Epo) is essential for formation of mature red blood cells (RBC). However, the function of Epo receptor (EpoR)-dependent signaling pathways in the regulation of erythropoiesis remains unclear. To determine whether specific Stat signals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e975f69007eee0503944cddae875d0e0
https://europepmc.org/articles/PMC2422832/
https://europepmc.org/articles/PMC2422832/
Autor:
Kim R. Lavenburg, Dennis K. Watson, Pamela N. Pharr, Takis S. Papas, Demetri D. Spyropoulos, Makio Ogawa, Pascale Jackers
The Ets family of transcription factors have been suggested to function as key regulators of hematopoeisis. Here we describe aberrant hematopoeisis and hemorrhaging in mouse embryos homozygous for a targeted disruption in the Ets family member, Fli1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbcdab22d3d209d26a96ba6f49ecc84a
https://europepmc.org/articles/PMC86032/
https://europepmc.org/articles/PMC86032/
Autor:
Gregory R. Johnson, Grant A. McArthur, Pamela N. Pharr, Andrey S. Shaw, Gregory D. Longmore, J. William Tanner
Publikováno v:
Gene Technology ISBN: 9783642647048
The receptor for erythropoietin is restricted to cells of mature erythroid and possibly megakaryocyte lineages. Studies in cell lines have suggested that cytokine receptors share a conserved signaling pathway for proliferation. We retrovirally transd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f574e996ecb3a39f838c1b65556bbcf
https://doi.org/10.1007/978-3-642-61122-3_23
https://doi.org/10.1007/978-3-642-61122-3_23
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 91(16)
Whether the presence of specific receptors on the surface of developing cells is the cause or consequence of lineage restriction is not known. If activation of specific receptors is the driving event in differentiation, the premature expression of sp
Publikováno v:
Molecular and cellular biology. 14(4)
If the env gene of spleen focus-forming virus (SFFV) is replaced by a cDNA encoding a constitutively active form of the erythropoietin receptor, EPO-R(R129C), the resultant recombinant virus, SFFVcEPO-R, induces transient thrombocytosis and erythrocy