Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Pamela M.J. McLaughlin"'
Publikováno v:
Clinical Chemistry and Laboratory Medicine (CCLM). 51:897-905
Background: Surface neutrophil CD64 expression is upregulated in patients with bacterial infection. As it was suggested that the CD64 index could be used to detect sepsis in hospitalized patients, we questioned whether the CD64 index could discrimina
Autor:
Marcel H. J. Ruiters, Lieuwe J. Melchers, Lou F. M. H. de Leij, Marianne G. Rots, Pamela M.J. McLaughlin, Bernardina T. F. van der Gun
Publikováno v:
CARCINOGENESIS. 31(11):1913-1921
The epithelial cell adhesion molecule (EpCAM) is a membrane glycoprotein that is highly expressed on most carcinomas and therefore of potential use as a diagnostic and prognostic marker for a variety of carcinomas. Interestingly, EpCAM is explored as
Autor:
Alice Arendzen, Maria Maluszynska-Hoffman, Antal Kiss, Marianne G. Rots, Elmar Weinhold, Pamela M.J. McLaughlin, Bernardina T. F. van der Gun, Marcel H. J. Ruiters
Publikováno v:
BIOCONJUGATE CHEMISTRY, 21(7), 1239-1245. AMER CHEMICAL SOC
Bioconjugate Chemistry
Bioconjugate Chemistry
The epithelial cell adhesion molecule (EpCAM) is a membrane glycoprotein that has been identified as a marker of cancer-initiating cells. EpCAM is highly expressed on most carcinomas, and transient silencing of EpCAM expression leads to reduced oncog
Autor:
Michael Kokkinidis, Gregor Meiss, Arūnas Šilanskas, T. M. Geel, Lou F. M. H. de Leij, Bernardina T. F. van der Gun, Alfred Pingoud, Marcel H. J. Ruiters, Marianne G. Rots, Pamela M.J. McLaughlin, Mindaugas Zaremba, Bart-Jan Kroesen
Publikováno v:
Experimental Cell Research, 315(15), 2487-2495. HANLEY & BELFUS-ELSEVIER INC
TRAIL induced apoptosis of tumor cells is currently entering phase II clinical settings, despite the fact that not all tumor types are sensitive to TRAIL. TRAIL resistance in ovarian carcinomas can be caused by a blockade upstream of the caspase 3 si
Autor:
Lou F. M. H. de Leij, Antal Kiss, Amélie Monami, Pamela M.J. McLaughlin, Bernardina T. F. van der Gun, Marcel H. J. Ruiters, Elmar Weinhold, Reinhold Wasserkort, Tamás Raskó, Krystyna Ślaska-Kiss, Marianne G. Rots, Rene Cortese, Albert Jeltsch
Publikováno v:
International Journal of Cancer. 123:484-489
The epithelial cell adhesion molecule (EpCAM) is expressed at high levels on the surface of most carcinoma cells. SiRNA silencing of EpCAM expression leads to reduced metastatic potential of tumor cells demonstrating its importance in oncogenesis and
Autor:
Martin C. Harmsen, Eliane R. Popa, Albertus Timmer, Monika Trzpis, Pamela M.J. McLaughlin, Sergio F.F. Santos, Gerrit W. Bosman, Harry van Goor, Marcela Anjos Martins, Mariana Alves de Sá Siqueira, Monique B. Moss, Lou M.F.H. de Leij, Giovanni E. Mann, Tatiana M.C. Brunini, Antonio C. Mendes-Ribeiro, Natália Rodrigues Pereira
Publikováno v:
Nephron Experimental Nephrology. 107:I-V
Autor:
Lou M.F.H. de Leij, Peter Terpstra, Eliane R. Popa, Monika Trzpis, Pamela M.J. McLaughlin, Theo G. van Kooten, Martin C. Harmsen
Publikováno v:
Transgenic Res, 17(2), 229-238
The Epithelial Cell Adhesion Molecule (EpCAM) is expressed virtually on normal epithelia in vertebrates. Among different species, the amino acid sequence of EpCAM is highly homologous, indicating that EpCAM is an evolutionary conserved protein. Howev
Publikováno v:
The American Journal of Pathology. 171:386-395
The epithelial cell adhesion molecule (EpCAM, CD326) is a glycoprotein of ∼40 kd that was originally identified as a marker for carcinoma, attributable to its high expression on rapidly proliferating tumors of epithelial origin. Normal epithelia ex
Autor:
Lou F. M. H. de Leij, Marjolijn N. Lub-de Hooge, Evert van Garderen, Pamela M.J. McLaughlin, Jos G. W. Kosterink, Jacoba van Zanten, Harry H. Hendrikse, Martin C. Harmsen
Publikováno v:
Journal of Immunology, 179(2), 1362-1368. AMER ASSOC IMMUNOLOGISTS
The human pancarcinoma-associated epithelial cell adhesion molecule (EpCAM) (EGP-2, CO17-1A) is a well-known target for carcinoma-directed immunotherapy. Mouse-derived mAbs directed to EpCAM have been used to treat colon carcinoma patients showing we
Autor:
Beatrice I. Lindhout, D. J. Wiegman, Marianne G. Rots, WM Gommans, David J. Segal, Pamela M.J. McLaughlin, Bert J. van der Zaal, Hidde J. Haisma
Publikováno v:
Molecular carcinogenesis, 46(5), 391-401
Zinc finger protein transcription factors (ZFP-TFs) are emerging as powerful novel tools for the treatment of many different diseases. ZFPs are DNA-binding motifs and consist of modular zinc finger domains. Each domain can be engineered to recognize