Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Pamela M. Martin"'
Autor:
Ravirajsinh N. Jadeja, Malita A. Jones, Ammar A. Abdelrahman, Folami L. Powell, Menaka C. Thounaojam, Diana Gutsaeva, Manuela Bartoli, Pamela M. Martin
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
The retinal pigment epithelium (RPE) is consistently exposed to high levels of pro-oxidant and inflammatory stimuli. As such, under normal conditions the antioxidant machinery in the RPE cell is one of the most efficient in the entire body. However,
Externí odkaz:
https://doaj.org/article/ec994286402a463f82b458cbbb257d5d
Autor:
Kapil K. Upadhyay, Ravirajsinh N. Jadeja, Hitarthi S. Vyas, Bhaumik Pandya, Apeksha Joshi, Aliasgar Vohra, Menaka C. Thounaojam, Pamela M. Martin, Manuela Bartoli, Ranjitsinh V. Devkar
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
Nuclear factor-erythroid 2 related factor 2 (Nrf2)-mediated signaling plays a central role in maintaining cellular redox homeostasis of hepatic cells. Carbon monoxide releasing molecule-A1 (CORM-A1) has been reported to stimulate up-regulation and nu
Externí odkaz:
https://doaj.org/article/7ea2765ab5b0424b9f2bedbf1e73555a
Publikováno v:
Antioxidants, Vol 10, Iss 5, p 790 (2021)
Inflammation and oxidative stress play prominent roles in the pathogenesis of many degenerative diseases of the retina, such as age-related macular degeneration (AMD), diabetic retinopathy (DR), retinal vein occlusion, and retinitis pigmentosa [...]
Externí odkaz:
https://doaj.org/article/2f311bb24db64d7cb16c4a4e07258a95
Autor:
Qi Wang, Svetlana Navitskaya, Harshini Chakravarthy, Chao Huang, Nermin Kady, Todd A. Lydic, Y. Eugene Chen, Ke-Jie Yin, Folami Lamoke Powell, Pamela M. Martin, Maria B. Grant, Julia V. Busik
Publikováno v:
EBioMedicine, Vol 11, Iss C, Pp 138-150 (2016)
Activation of pro-inflammatory and pro-angiogenic pathways in the retina and the bone marrow contributes to pathogenesis of diabetic retinopathy. We identified miR-15a as key regulator of both pro-inflammatory and pro-angiogenic pathways through dire
Externí odkaz:
https://doaj.org/article/2a68a1d0185d4c5281617ed0199833fd
Autor:
Alice Win, Amanda Delgado, Ravirajsinh N. Jadeja, Pamela M. Martin, Manuela Bartoli, Menaka C. Thounaojam
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 292 (2021)
Bile acids (BAs) are amphipathic sterols primarily synthesized from cholesterol in the liver and released in the intestinal lumen upon food intake. BAs play important roles in micellination of dietary lipids, stimulating bile flow, promoting biliary
Externí odkaz:
https://doaj.org/article/c7e9b3a4d3b2433c83ac5824efe10946
Autor:
Pachiappan Arjunan, Radhika Swaminathan, Jessie Yuan, Mohamed Elashiry, Amany Tawfik, Mohamed Al-Shabrawey, Pamela M. Martin, Thangaraju Muthusamy, Christopher W. Cutler
Publikováno v:
Antioxidants, Vol 10, Iss 2, p 309 (2021)
Emerging evidence underscores an association between age-related macular degeneration (AMD) and periodontal disease (PD), yet the biological basis of this linkage and the specific role of oral dysbiosis caused by PD in AMD pathophysiology remains unc
Externí odkaz:
https://doaj.org/article/33c198dd02fc49d2a86a72832cf53b1e
Autor:
Sudha Ananth, Seiji Miyauchi, Muthusamy Thangaraju, Ravirajsinh N. Jadeja, Manuela Bartoli, Vadivel Ganapathy, Pamela M. Martin
Publikováno v:
Antioxidants, Vol 10, Iss 1, p 9 (2020)
Oxidative damage has been identified as a major causative factor in degenerative diseases of the retina; retinal pigment epithelial (RPE) cells are at high risk. Hence, identifying novel strategies for increasing the antioxidant capacity of RPE cells
Externí odkaz:
https://doaj.org/article/e87aa7a9230d4a9da90506a0ed6217b9
Autor:
Hossameldin Abouhish, Menaka C. Thounaojam, Ravirajsinh N. Jadeja, Diana R. Gutsaeva, Folami L. Powell, Mohamed Khriza, Pamela M. Martin, Manuela Bartoli
Publikováno v:
Antioxidants, Vol 9, Iss 7, p 599 (2020)
We investigated the contributing role of the histone deacetylase 6 (HDAC6) to the early stages of diabetic retinopathy (DR). Furthermore, we examined the mechanism of action of HDAC6 in human retinal endothelial cells (HuREC) exposed to glucidic stre
Externí odkaz:
https://doaj.org/article/196a88b993884b209ec1fd93381e9838
Autor:
Menaka C. Thounaojam, Ravirajsinh N. Jadeja, Shubhra Rajpurohit, Diana R. Gutsaeva, Brian K. Stansfield, Pamela M. Martin, Manuela Bartoli
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 6, p 1921 (2020)
Retinopathy of prematurity (ROP) is the leading cause of blindness in infants. We have investigated the efficacy of the secondary bile acid ursodeoxycholic acid (UDCA) and its taurine and glycine conjugated derivatives tauroursodeoxycholic acid (TUDC
Externí odkaz:
https://doaj.org/article/7c41ef27182b472d83b8e481aae53896
Autor:
Menaka C. Thounaojam, Ravirajsinh N. Jadeja, Marie Warren, Folami L. Powell, Raghavan Raju, Diana Gutsaeva, Sandeep Khurana, Pamela M. Martin, Manuela Bartoli
Publikováno v:
Antioxidants, Vol 8, Iss 9, p 328 (2019)
Stress-associated premature senescence (SAPS) is involved in retinal microvascular injury and diabetic retinopathy. We have investigated the role and mode of action of miR-34a in retinal endothelial cells senescence in response to glucidic stress. Hu
Externí odkaz:
https://doaj.org/article/1d522235784e494a93efbbcf08251c81