Analogs of the Dopamine Metabolite 5,6-Dihydroxyindole Bind Directly to and Activate the Nuclear Receptor Nurr1

Autor: Yoshie Iizuka, Geoffrey Lang, Pamela M. England, Matthew P. Jacobson, Svetlana A. Kholodar, Harman S. Brah, Wilian A. Cortopassi

Publikováno v: ACS Chem Biol
ACS chemical biology, vol 16, iss 7

The nuclear receptor-related 1 protein, Nurr1, is a transcription factor critical for the development and maintenance of dopamine-producing neurons in the substantia nigra pars compacta, a cell population that progressively loses the ability to make

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae62dc14c3a8a63dca89796f85c3ab54
https://doi.org/10.1021/acschembio.1c00326

Analogs of the Dopamine Metabolite 5,6-Dihydroxyindole Bind Directly to and Activate the Nuclear Receptor Nurr1 (NR4A2)

Autor: Geoffrey Lang, Yoshie Iizuka, Pamela M. England, Harman S. Brah, Wilian A. Cortopassi, Svetlana A. Kholodar, Matthew P. Jacobson

The nuclear receptor-related 1 protein, Nurr1, is a transcription factor critical for the development and maintenance of dopamine-producing neurons in the substantia nigra pars compacta, a cell population that progressively loses the ability to make

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a47385979bf52589504aab9d2f3cbc1c
https://doi.org/10.1101/2021.05.09.442997

Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite

Autor: Robert J. Fletterick, Paulomi Bhattacharya, Svetlana A. Kholodar, Harrison Liu, Pamela M. England, James M. Holton, Matthew P. Jacobson, Francesca Oltrabella, Yan Wang, Su Guo, Boxue Tian, John M. Bruning

Publikováno v: Cell Chem Biol
Cell chemical biology, vol 26, iss 5

SUMMARYNurr1, a nuclear receptor essential for the development, maintenance, and survival of midbrain dopaminergic neurons, is a potential therapeutic target for Parkinson’s disease, a neurological disorder characterized by the degeneration of thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5bd236832a5ef0e35903b62f4f0616
https://doi.org/10.1016/j.chembiol.2019.02.002

Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2)

Autor: Elena P. Sablin, Miyuki Suzawa, John M. Bruning, Pamela M. England, Sam Irvy, Holly A. Ingraham, Felipe de Jesus Cortez, Matthew P. Jacobson, Robert J. Fletterick

Publikováno v: PLoS ONE
Cortez, FDJ; Suzawa, M; Irvy, S; Bruning, JM; Sablin, E; Jacobson, MP; et al.(2016). Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2). PLOS ONE, 11(7). doi: 10.1371/journal.pone.0159316. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/2bp084k5
PloS one, vol 11, iss 7
PLoS ONE, Vol 11, Iss 7, p e0159316 (2016)

Conventional efforts relying on high-throughput physical and virtual screening of large compound libraries have failed to yield high-efficiency chemical probes for many of the 48 human nuclear receptors. Here, we investigated whether disulfide-trappi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ef56c8f107be1a429f767ffa97b5dc5
http://europepmc.org/articles/PMC4965143

TrkB kinase is required for recovery, but not loss, of cortical responses following monocular deprivation

Autor: Jessica L Hanover, Michael P. Stryker, Megumi Kaneko, Pamela M. England

Publikováno v: Nature Neuroscience. 11:497-504

Changes in visual cortical responses that are induced by monocular visual deprivation are a widely studied example of competitive, experience-dependent neural plasticity. It has been thought that the deprived-eye pathway will fail to compete against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705d29a34ef39a0066462897985a734f
https://doi.org/10.1038/nn2068