Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Pamela M. Carroll"'
Autor:
Jessica Baker Flechtner, Thomas A. Davis, Pamela M. Carroll, Charles G. Drake, Kwok-Kin Wong, Elizabeth M. Jaffee, Parul Agnihotri, Wendy Broom, Daniel B. DeOliveira, Kyle Ferber, Emily Tjon, Vijetha Vemulapalli, James J. Foti, Arthur P. DeCillis, Ulka N. Vaishampayan, Mark N. Stein, Maura L. Gillison, Melissa L. Johnson, Przemyslaw Twardowski, Roger B. Cohen, Victoria L. DeVault, Hanna Starobinets, Lisa K. McNeil, Hubert Lam
Neoantigens are critical targets of antitumor T-cell responses. The ATLAS bioassay was developed to identify neoantigens empirically by expressing each unique patient-specific tumor mutation individually in Escherichia coli, pulsing autologous dendri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69391e7bebbc1a1098be422e085f1940
https://doi.org/10.1158/2159-8290.c.6548228.v1
https://doi.org/10.1158/2159-8290.c.6548228.v1
Autor:
Jessica Baker Flechtner, Thomas A. Davis, Pamela M. Carroll, Charles G. Drake, Kwok-Kin Wong, Elizabeth M. Jaffee, Parul Agnihotri, Wendy Broom, Daniel B. DeOliveira, Kyle Ferber, Emily Tjon, Vijetha Vemulapalli, James J. Foti, Arthur P. DeCillis, Ulka N. Vaishampayan, Mark N. Stein, Maura L. Gillison, Melissa L. Johnson, Przemyslaw Twardowski, Roger B. Cohen, Victoria L. DeVault, Hanna Starobinets, Lisa K. McNeil, Hubert Lam
Supplementary Table from An Empirical Antigen Selection Method Identifies Neoantigens That Either Elicit Broad Antitumor T-cell Responses or Drive Tumor Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078f1d611a139d47d9a2839b5a415c3e
https://doi.org/10.1158/2159-8290.22536755
https://doi.org/10.1158/2159-8290.22536755
Autor:
Jessica Baker Flechtner, Thomas A. Davis, Pamela M. Carroll, Charles G. Drake, Kwok-Kin Wong, Elizabeth M. Jaffee, Parul Agnihotri, Wendy Broom, Daniel B. DeOliveira, Kyle Ferber, Emily Tjon, Vijetha Vemulapalli, James J. Foti, Arthur P. DeCillis, Ulka N. Vaishampayan, Mark N. Stein, Maura L. Gillison, Melissa L. Johnson, Przemyslaw Twardowski, Roger B. Cohen, Victoria L. DeVault, Hanna Starobinets, Lisa K. McNeil, Hubert Lam
Supplementary Figure from An Empirical Antigen Selection Method Identifies Neoantigens That Either Elicit Broad Antitumor T-cell Responses or Drive Tumor Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1af50888ce099e83501cd69eefc22b
https://doi.org/10.1158/2159-8290.22536761.v1
https://doi.org/10.1158/2159-8290.22536761.v1
Autor:
Christopher G. Winter, Peter R. Strack, A. Thomas Look, Giulio F. Draetta, Pamela M. Carroll, Lex H.T. Van der Ploeg, Victoria M. Richon, Nancy E. Kohl, Jing Yuan, Edyta Tyminski, Theresa Zhang, Xudong Dai, James S. Hardwick, Cole D. Liberator, Jennifer O'Neil, Sudhir S. Rao
Supplementary Figures 1-5, Tables 1-2 from Inhibition of NOTCH Signaling by Gamma Secretase Inhibitor Engages the RB Pathway and Elicits Cell Cycle Exit in T-Cell Acute Lymphoblastic Leukemia Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f84e6c5996a6ff735be86409e33f2da1
https://doi.org/10.1158/0008-5472.22381283
https://doi.org/10.1158/0008-5472.22381283
Autor:
Christopher G. Winter, Peter R. Strack, A. Thomas Look, Giulio F. Draetta, Pamela M. Carroll, Lex H.T. Van der Ploeg, Victoria M. Richon, Nancy E. Kohl, Jing Yuan, Edyta Tyminski, Theresa Zhang, Xudong Dai, James S. Hardwick, Cole D. Liberator, Jennifer O'Neil, Sudhir S. Rao
NOTCH signaling is deregulated in the majority of T-cell acute lymphoblastic leukemias (T-ALL) as a result of activating mutations in NOTCH1. Gamma secretase inhibitors (GSI) block proteolytic activation of NOTCH receptors and may provide a targeted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd0c322caf65d182c409eae549f488e7
https://doi.org/10.1158/0008-5472.c.6499817.v1
https://doi.org/10.1158/0008-5472.c.6499817.v1
Autor:
Wendy Broom, Elizabeth M. Jaffee, Daniel DeOliveira, Victoria L. DeVault, Charles G. Drake, Ulka N. Vaishampayan, Arthur P. Decillis, Vijetha Vemulapalli, Maura L. Gillison, Mark N. Stein, Pamela M. Carroll, Kyle Ferber, Parul Agnihotri, Emily Tjon, Hubert Lam, Jessica Flechtner, James Foti, Roger B. Cohen, Lisa K. McNeil, Hanna Starobinets, Melissa Lynne Johnson, Przemyslaw Twardowski, Thomas A. Davis, Kwok-Kin Wong
Publikováno v:
Cancer Discovery. 11:696-713
Neoantigens are critical targets of antitumor T-cell responses. The ATLAS bioassay was developed to identify neoantigens empirically by expressing each unique patient-specific tumor mutation individually in Escherichia coli, pulsing autologous dendri
Autor:
D. Gary Gilliland, Jannik N. Andersen, Peter Strack, Kumiko Nagashima, Pamela M. Carroll, Erica M. Cook, Thi D.T. Nguyen, Marc Ferrer, Erick J. Morris, Bryan Severyn, Andrey Loboda, Jeff Hermes, Michelle A. Cleary, Sriram Sathyanarayanan, Bill Arthur, Yair Benita, Lixia Li, G. Naumov, Michael D. Altman, James Watters, Matthew Tudor
Publikováno v:
SLAS Discovery. 21:989-997
The RAS-MAPK pathway controls many cellular programs, including cell proliferation, differentiation, and apoptosis. In colorectal cancers, recurrent mutations in this pathway often lead to increased cell signaling that may contribute to the developme
Autor:
Gregory D. Plowman, Casey Kopczynski, Kim Lickteig, Lori Friedman, Christopher G. Winter, Matt B. Mahoney, Kellie Whittaker, Helen Francis-Lang, Marcia Belvin, Matthew V. Lorenzi, Ferhad Ahmad, Hanife Esengil, Annette L. Parks, Brent A. Rupnow, Monique Nicoll, Feng Chen, Lynn M. Young, Mariano Tabios, Kyle A. Edgar, Christopher C. Park, Amanda Norton, Laleh Shayesteh, Pamela M. Carroll
Publikováno v:
Genetics. 170:161-171
Mutations that inactivate the retinoblastoma (Rb) pathway are common in human tumors. Such mutations promote tumor growth by deregulating the G1 cell cycle checkpoint. However, uncontrolled cell cycle progression can also produce new liabilities for
Autor:
Hangjun Zhan, Hong Xiao, Katherine Brown, Yvonne Franke, Bo Guan, Kevin Patrick Keegan, Michael Robert Cancilla, Rachel M. Kindt, Rajashekar K. Reddy, Changyou Chen, Juan J. Perez-Villar, Tim Heuer, Dianne Parry, Veeraswamy Manne, Carol O'Brien, Mark I. Cockett, Greg D Plowman, Kevin Fitzgerald, Petra Ross-Macdonald, Mark R. Lackner, Pamela M. Carroll, Michael Costa, Jae Moon Lee, Tak Hung, Heshani de Silva
Publikováno v:
Cancer Cell. 7:325-336
SummaryA chemical genetics approach identified a cellular target of several proapoptotic farnesyl transferase inhibitors (FTIs). Treatment with these FTIs caused p53-independent apoptosis in Caenorhabditis elegans, which was mimicked by knockdown of
Autor:
Kevin Fitzgerald, Brian A. Dougherty, Kailtin Browman, Pamela M. Carroll, Petra Ross-Macdonald
Publikováno v:
Pharmacology & Therapeutics. 99:183-220
Animal model systems are an intricate part of the discovery and development of new medicines. The sequencing of not only the human genome but also those of the various pathogenic bacteria, the nematode Caenorhabditis elegans, the fruitfly Drosophila,