Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Pamela L. Tannenbaum"'
Autor:
Pamela L. Tannenbaum, Joanne eStevens, Jacquelyn eBinns, Alan eSavitz, Susan L Garson, Steven V Fox, Paul eColeman, Scott D Kuduk, Anthony L Gotter, Michael eMarino, Spencer J Tye, Jason eUslaner, Christopher J Winrow, John J Renger
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 8 (2014)
The ability to awaken from sleep in response to important stimuli is a critical feature of normal sleep, as is maintaining sleep continuity in the presence of irrelevant background noise. Dual orexin receptor antagonists (DORAs) effectively promote s
Externí odkaz:
https://doaj.org/article/bc2e2cdd06ec407c9158c769a6c72cea
Autor:
Andres D. Ramirez, Anthony L. Gotter, Steven V. Fox, Pamela L. Tannenbaum, Lihang eYao, Spencer J. Tye, Terrence eMcDonald, Joseph eBrunner, Susan L. Garson, Duane R. Reiss, Scott D. Kuduk, Paul J. Coleman, Jason M. Uslaner, Robert eHodgson, Susan E. Browne, John J. Renger, Christopher J. Winrow
Publikováno v:
Frontiers in Neuroscience, Vol 7 (2013)
Dual orexin receptor antagonists (DORAs) are a potential treatment for insomnia that function by blocking both the orexin 1 and orexin 2 receptors. The objective of the current study was to further confirm the impact of therapeutic mechanisms targeti
Externí odkaz:
https://doaj.org/article/7a637e4e89e342579deeac811d80cf1d
Autor:
Christina N. DiMarco, Anthony L. Gotter, Alan T. Savitz, Joanne Stevens, Joseph G. Bruno, Tamara D. Cabalu, John J. Renger, Jason W. Skudlarek, Pamela L. Tannenbaum, Paul J. Coleman, Scott D. Kuduk, Joseph Brunner, Susan L. Garson, Christopher J. Winrow, Julie A. O'Brien, Charles M. Harrell, Mark H. Pausch
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:2488-2492
Antagonism of orexin receptors has shown clinical efficacy as a novel paradigm for the treatment of insomnia and related disorders. Herein, molecules related to the dual orexin receptor antagonist filorexant were transformed into compounds that were
Autor:
John J. Renger, Joyce Stellabott, Swati P. Mercer, Wei Lemaire, Thomas S. Reger, Christopher D. Cox, Pamela L. Tannenbaum, Christopher J. Winrow, Joanne Stevens, Donghui Cui, Joseph G. Bruno, Susan L. Garson, Rowena V. Cube, M. Christa Mattern, Dansu Li, C. Meacham Harrell, Paul J. Coleman, John D. Schreier, Tamara D. Cabalu, George D. Hartman, Anthony L. Gotter, Steven V. Fox, Jeffrey M. Bergman, Anthony J. Roecker, Thomayant Prueksaritanont, Steven D. Young
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4884-4890
Orexin receptor antagonists have demonstrated clinical utility for the treatment of insomnia. The majority of clinical efforts to date have focused on the development of dual orexin receptor antagonists (DORAs), small molecules that antagonize both t
Autor:
Christopher J. Winrow, Joanne Stevens, Anthony J. Roecker, Charles M. Harrell, Alan T. Savitz, W. Peter Wuelfing, Kerim Babaoglu, Jason W. Skudlarek, Paul J. Coleman, Steven V. Fox, Christina Ng Dimarco, Pamela L. Tannenbaum, Scott D. Kuduk, Susan L. Garson, Joseph G. Bruno, Joseph Brunner, John J. Renger, Tamara D. Cabalu, Anthony L. Gotter, Mark A. Pausch, Julie A. O'Brien
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(6)
In an ongoing effort to explore the use of orexin receptor antagonists for the treatment of insomnia, dual orexin receptor antagonists (DORAs) were structurally modified, resulting in compounds selective for the OX2R subtype and culminating in the di
Autor:
Pamela L. Tannenbaum, Scott D. Kuduk, Tamara D. Cabalu, Joseph Brunner, Mark A. Pausch, Christina N. Di Marco, Joseph G. Bruno, Paul J. Coleman, Anthony L. Gotter, John J. Renger, Joanne Stevens, Jason W. Skudlarek, Christopher J. Winrow, Julie A. O'Brien
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:1784-1789
Analogs of the dual orexin receptor antagonist filorexant were prepared. Replacement of the ether linkage proved highly sensitive toward modification with an acetylene linkage providing compounds with the best in vitro and in vivo potency profiles.
Autor:
Anthony L. Gotter, Vladimir Svetnik, Arie Struyk, Pamela L. Tannenbaum, Mark S. Forman, Nicole Calder, Susan L. Garson, John J. Renger, Christopher J. Winrow, Joanne Stevens, Anthony J. Roecker, Laura B. Rosen, W. Joseph Herring, Ka Lai Yee, Inge De Lepeleire, Xiaodong Li, Paul J. Coleman, Steven V. Fox, Charles M. Harrell
Publikováno v:
Scientific Reports
Orexin neuropeptides regulate sleep/wake through orexin receptors (OX1R, OX2R); OX2R is the predominant mediator of arousal promotion. The potential for single OX2R antagonism to effectively promote sleep has yet to be demonstrated in humans. MK-1064
Autor:
Jason M. Uslaner, John J. Renger, Anthony L. Gotter, Paul J. Coleman, Steven V. Fox, Richard Hargreaves, Joanne Stevens, Pamela L. Tannenbaum, Christopher J. Winrow, Scott D. Kuduk, Alan T. Savitz, Spencer J. Tye
Study objectives In addition to enhancing sleep onset and maintenance, a desirable insomnia therapeutic agent would preserve healthy sleep's ability to wake and respond to salient situations while maintaining sleep during irrelevant noise. Dual orexi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::807966889585d73e00c8aa7c7dff031e
https://europepmc.org/articles/PMC4763356/
https://europepmc.org/articles/PMC4763356/
Autor:
Michael J. Breslin, Paul J. Coleman, Duane R. Reiss, Christopher D. Cox, Anthony L. Gotter, Joanne Stevens, Scott M. Doran, John D. Schreier, Donghui Cui, Christopher J. Winrow, John J. Renger, Steven V. Fox, Charles M. Harrell, Pamela L. Tannenbaum, Susan L. Garson
Publikováno v:
Neuropharmacology. 62:978-987
Orexin (hypocretin) neuropeptides promote wakefulness by signaling through two G-protein coupled receptors, Orexin 1 Receptor (OX(1)R) and Orexin 2 Receptor (OX(2)R). MK-6096 is an orally bioavailable potent and selective reversible antagonist of OX(
Autor:
Pamela L. Tannenbaum, Craig F. Ferris, Toni E. Ziegler, Nancy Schultz-Darken, Charles T. Snowdon
Publikováno v:
Hormones and Behavior. 59:696-701
Conditioning of sexual arousal has been demonstrated in several species from fish to humans but has not been demonstrated in nonhuman primates. Controversy exists over whether nonhuman primates produce pheromones that arouse sexual behavior. Although