Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Pamela L, Zeitlin"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Quantitation of CFTR function in vitro is commonly performed by acutely stimulating then inhibiting ion transport through CFTR and measuring the resulting changes in transepithelial voltage (Vte) and current (ISC). While this technique is su
Externí odkaz:
https://doaj.org/article/8dd03599bdb7470298956a04c6a75ed2
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-4 (2021)
Externí odkaz:
https://doaj.org/article/340dd07fd2344aaf8ea3bac3a33a3f78
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), which lead to early death due to progressive lung disease. The development of small-molecule modulators that directly interact wit
Externí odkaz:
https://doaj.org/article/ada0900b04f2474491bb981f326adf27
Autor:
Maya E. Kotas, Camille M. Moore, Jose G. Gurrola II, Steven D. Pletcher, Andrew N. Goldberg, Raquel Alvarez, Sheyla Yamato, Preston E. Bratcher, Ciaran A. Shaughnessy, Pamela L. Zeitlin, Irene H. Zhang, Yingchun Li, Michael T. Montgomery, Keehoon Lee, Emily K. Cope, Richard M. Locksley, Max A. Seibold, Erin D. Gordon
Publikováno v:
JCI Insight, Vol 7, Iss 13 (2022)
Chronic type 2 (T2) inflammatory diseases of the respiratory tract are characterized by mucus overproduction and disordered mucociliary function, which are largely attributed to the effects of IL-13 on common epithelial cell types (mucus secretory an
Externí odkaz:
https://doaj.org/article/6f5341174d7842269c992904cbd03de8
Publikováno v:
BMJ Open Respiratory Research, Vol 8, Iss 1 (2021)
Introduction The incubation of airway epithelia cells at low temperatures is a common in vitro experimental approach used in the field of cystic fibrosis (CF) research to thermo-stabilise F508del-CFTR and increase its functional expression. Given tha
Externí odkaz:
https://doaj.org/article/a8a2166685bd4b53a0d876b3a9dc4cf9
Publikováno v:
Physiological Reports, Vol 8, Iss 19, Pp n/a-n/a (2020)
Abstract Introduction One method for assessing the in vitro response to CFTR‐modulating compounds is by analysis of epithelial monolayers in an Ussing chamber, where the apical and basolateral surfaces are isolated and the potential difference, sho
Externí odkaz:
https://doaj.org/article/cbecdc03fbdc48c6b66e43318d5afcf5
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports
Scientific Reports
Quantitation of CFTR function in vitro is commonly performed by acutely stimulating then inhibiting ion transport through CFTR and measuring the resulting changes in transepithelial voltage (Vte) and current (ISC). While this technique is suitable fo
Autor:
Pamela L. Zeitlin, Preston E. Bratcher
Publikováno v:
Annals of the American Thoracic Society. 18:1776-1779
Autor:
Lawrence M. Nogee, Pamela L. Zeitlin
Publikováno v:
Pediatric allergy, immunology, and pulmonology. 24(1)
Bronchopulmonary dysplasia affects thousands of infants annually with high attendant morbidity, mortality, and healthcare costs. Respiratory outcomes for preterm infants may be widely disparate even within the same medical center for infants of simil
Autor:
Kathryn A. Carson, Garry R. Cutting, Joseph M. Collaco, Peter J. Mogayzel, Pamela L. Zeitlin, Melis A. Aksit, Vanessa L. Richardson, Beth L. Laube, Christopher M. Evans, Gail Sharpless
Publikováno v:
Pediatric Research. 91:612-620
Background This research characterized mucociliary clearance (MCC) in young children with cystic fibrosis (CF). Methods Fourteen children (5-7 years old) with CF underwent: two baseline MCC measurements (Visits 1 and 2); one MCC measurement approxima