Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Pamela K. Wagner"'
Autor:
Bethany A. Adair, Andrea J. Korecki, Diana Djaksigulova, Pamela K. Wagner, Nina Y. Chiu, Siu Ling Lam, Tess C. Lengyell, Blair R. Leavitt, Elizabeth M. Simpson
Publikováno v:
Ophthalmology and Therapy, Vol 12, Iss 4, Pp 2049-2068 (2023)
Abstract Introduction Aniridia is a rare congenital vision-loss disease caused by heterozygous variants in the PAX6 gene. There is no vision-saving therapy, but one exciting approach is to use CRISPR/Cas9 to permanently correct the causal genomic var
Externí odkaz:
https://doaj.org/article/236a9d7004ac47589a17158051a80833
Autor:
Seyedeh Zeinab Mirjalili Mohanna, Diana Djaksigulova, Austin M. Hill, Pamela K. Wagner, Elizabeth M. Simpson, Blair R. Leavitt
Publikováno v:
Journal of Controlled Release. 350:401-413
CRISPR/Cas9-based genome-editing therapies are poised to change the clinical outcome for many diseases with validated therapeutic targets awaiting an appropriate delivery system. Recent advances in lipid nanoparticle (LNP) technology make them an att
Autor:
Sarah B. Thomson, Josh Zaifman, Blair R. Leavitt, Terri L. Petkau, Jayesh A. Kulkarni, Pieter R. Cullis, Austin Hill, Jerry Leung, Yuen Yi C. Tam, Pamela K. Wagner
Publikováno v:
Nanoscale
Lipid nanoparticle (LNP) formulations of nucleic acid are leading vaccine candidates for COVID-19, and enabled the first approved RNAi therapeutic, Onpattro. LNPs are composed of ionizable cationic lipids, phosphatidylcholine, cholesterol, and polyet
Publikováno v:
Reproductive Biology and Endocrinology, Vol 9, Iss 1, p 48 (2011)
Reproductive Biology and Endocrinology : RB&E
Reproductive Biology and Endocrinology : RB&E
Background Pregnancy-associated plasma protein A2 (PAPPA2) is an insulin-like growth factor-binding protein (IGFBP) protease expressed at high levels in the placenta and upregulated in pregnancies complicated by preeclampsia and HELLP (Hemolytic anem
Autor:
Pamela K Wagner, Julian K. Christians
Publikováno v:
Reproductive Biology and Endocrinology : RB&E
Reproductive Biology and Endocrinology, Vol 8, Iss 1, p 90 (2010)
Reproductive Biology and Endocrinology, Vol 8, Iss 1, p 90 (2010)
Background Pregnancy-associated plasma protein A2 (PAPPA2) is an insulin-like growth factor binding protein (IGFBP) protease expressed in the placenta and upregulated in pregnancies complicated by pre-eclampsia. The mechanism linking PAPPA2 expressio
Autor:
Adair, Bethany A.1,2 (AUTHOR), Korecki, Andrea J.1 (AUTHOR), Djaksigulova, Diana1 (AUTHOR), Wagner, Pamela K.3 (AUTHOR), Chiu, Nina Y.1,2 (AUTHOR), Lam, Siu Ling1 (AUTHOR), Lengyell, Tess C.1 (AUTHOR), Leavitt, Blair R.1,2,3 (AUTHOR), Simpson, Elizabeth M.1,2 (AUTHOR) simpson@cmmt.ubc.ca
Publikováno v:
Ophthalmology & Therapy. Aug2023, Vol. 12 Issue 4, p2049-2068. 20p.
Publikováno v:
Nanoscale; 12/21/2020, Vol. 12 Issue 47, p23873-23884, 12p
Autor:
Kulkarni, Jayesh A., Thomson, Sarah B., Zaifman, Josh, Leung, Jerry, Wagner, Pamela K., Hill, Austin, Tam, Yuen Yi C., Cullis, Pieter R., Petkau, Terri L., Leavitt, Blair R.
Publikováno v:
Nanoscale; 12/21/2020, Vol. 12 Issue 47, p23959-23966, 8p
Publikováno v:
Journal of Huntington's Disease. 2013, Vol. 2 Issue 3, p331-391. 61p.
Publikováno v:
Reproductive Biology & Endocrinology. 2011, Vol. 9 Issue 1, p48-54. 7p.