Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Pamela K. Shetler"'
Autor:
Kristy Kikly, Howard Barff Broughton, William Chang, Selma Sapmaz, Richard Morphy, Holly A. Bina, Jim D. Durbin, Sherry Y Guo, Timothy Ivo Richardson, Jimmy P Steele, Ryan Edward Stites, Brian G. Getman, Vaught Grant Matthews, Veavi Ching-Yun Chang, Pamela K. Shetler, Greg L Durst, Denise D Edmondson, Rob Barr, Helene Rudyk, Charles Willis Lugar, Nita J. Patel, Christian Alexander Clarke, Kelly Wayne Furness, Nicole E New, David K. Clawson, Keith R. Stayrook, Mark Chambers, Brian Michael Mathes, Stephanie L. Stout, Wendy H. Gough
Publikováno v:
Journal of Medicinal Chemistry. 64:5470-5484
The Th17 pathway has been implicated in autoimmune diseases. The retinoic acid receptor-related orphan receptor C2 (RORγt) is a master regulator of Th17 cells and controls the expression of IL-17A. RORγt is expressed primarily in IL-17A-producing l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a80dc241f7e50c8ddb367cc37ea913c
https://doi.org/10.1021/acs.jmedchem.0c01918
https://doi.org/10.1021/acs.jmedchem.0c01918
Autor:
Guilherme Rocha, Yanfei L. Ma, June Wiley, David J. Gifondorwa, Tyran D. Thompson, Henry Uhlman Bryant, Alexander E. Culver, Venkatesh Krishnan, Pamela K. Shetler
Publikováno v:
Muscle & Nerve. 54:1120-1132
Introduction: There is evidence that supports a role for Vitamin D (Vit. D) in muscle. The exact mechanism by which Vit. D deficiency impairs muscle strength and function is not clear. Methods: Three-week-old mice were fed diets with varied combinati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2161c4725a4fdc6f653a9fddb36b35d8
https://doi.org/10.1002/mus.25146
https://doi.org/10.1002/mus.25146
Autor:
Guoli Dai, Venkatesh Krishnan, Johnny E. Croy, Pamela K. Shetler, Amita Datta-Mannan, Alexander E. Culver, Andrea Milner, Jonathan M. Wilson, Benjamin C. Yaden, Yan X. Wang
Publikováno v:
The American Journal of Pathology. 184:1152-1166
Activin A, a member of the transforming growth factor-β superfamily, provides pleiotropic regulation of fibrosis and inflammation. We aimed at determining whether selective inhibition of activin A would provide a regenerative benefit. The introducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdcc81b0633d84156c8e76870fdba8fb
https://doi.org/10.1016/j.ajpath.2013.12.029
https://doi.org/10.1016/j.ajpath.2013.12.029
Autor:
David J, Gifondorwa, Tyran D, Thompson, June, Wiley, Alexander E, Culver, Pamela K, Shetler, Guilherme V, Rocha, Yanfei L, Ma, Venkatesh, Krishnan, Henry U, Bryant
Publikováno v:
Musclenerve. 54(6)
There is evidence that supports a role for Vitamin D (Vit. D) in muscle. The exact mechanism by which Vit. D deficiency impairs muscle strength and function is not clear.Three-week-old mice were fed diets with varied combinations of Vit. D and CaVit.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a35426b862c86f77f8ba601afe99cbf0
https://pubmed.ncbi.nlm.nih.gov/27074419
https://pubmed.ncbi.nlm.nih.gov/27074419
Autor:
Timothy Ivo Richardson, Chahrzad Montrose-Rafizadeh, Scott Alan Jones, Terry L. Moore, Thomas J. Bleisch, John J. Osborne, Charles Willis Lugar, Yu Kuo-Long, Jeffrey Alan Dodge, Pamela K. Shetler, Nita J. Patel, Christian Alexander Clarke, Andrew G. Geiser, Jose Eduardo Lopez, Rachelle J. Sells Galvin, Brian Stephen Muehl, Ying K. Yee, Norman Earle Hughes, Richard W. Zink
Publikováno v:
ACS Medicinal Chemistry Letters. 2:148-153
We report the synthesis and characterization of novel 3-aryl indoles as potent and efficacious progesterone receptor (PR) antagonists with potential for the treatment of uterine fibroids. These compounds demonstrated excellent selectivity over other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acdb4c9ff42035b27d8602e491bfe9d8
https://doi.org/10.1021/ml100220b
https://doi.org/10.1021/ml100220b
Autor:
Thomas P. Burris, Owen B. Wallace, Jeffrey Alan Dodge, Joel R. Calvin, Scott A. May, Kenneth S Lauwers, Andrew G. Geiser, Ronald Jay Hinklin, Pamela K. Shetler, Mary D. Adrian, Masahiko Sato, Henry Uhlman Bryant
Publikováno v:
Journal of Medicinal Chemistry. 49:843-846
A selective estrogen receptor modulator (SERM) for the potential treatment of hot flushes is described. (R)-(+)-7,9-difluoro-5-[4-(2-piperidin-1-ylethoxy)phenyl]-5H-6-oxachrysen-2-ol, LSN2120310, potently binds ERalpha and ERbeta and is an antagonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855f72212cafc3f21a8e6957d875b7ec
https://doi.org/10.1021/jm0509795
https://doi.org/10.1021/jm0509795
Autor:
Magee David Edward, Jeffrey Alan Dodge, Pamela K. Shetler, Mary D. Adrian, Henry Uhlman Bryant, Charles Willis Lugar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4281-4284
The pharmacology and SAR of representative equine estogens is described. 17alpha-Dihydroequilenin was found to prevent bone loss after 5 weeks of oral administration to ovariectomized rats. The stereochemical significance of the D-ring and the C/D ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ddfc7ea0e24394dbb1ae9326684cbe
https://doi.org/10.1016/j.bmcl.2003.09.060
https://doi.org/10.1016/j.bmcl.2003.09.060
Autor:
Keyue Chen, Heather A Bullock, Henry Uhlman Bryant, Venkatesh Krishnan, Pamela K. Shetler, James G. MacKrell, Benjamin C. Yaden
Publikováno v:
Nuclear Receptor Signaling
The high regenerative capacity of adult skeletal muscle relies on a self-renewing depot of adult stem cells, termed muscle satellite cells (MSCs). Androgens, known mediators of overall body composition and specifically skeletal muscle mass, have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a167c46b87e77ec63d178888ba8cff0
https://pubmed.ncbi.nlm.nih.gov/26457071
https://pubmed.ncbi.nlm.nih.gov/26457071
Autor:
Guoli Dai, Yan Wang, Johnny E. Croy, Pamela K. Shetler, Andrea Milner, Amita Datta-Mannan, Benjamin C. Yaden, Jonathan M. Wilson, Henry Uhlman Bryant, Jessica Andrews, Venkatesh Krishnan
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 349(2)
Follistatin (FST) is a member of the tissue growth factor β family and is a secreted glycoprotein that antagonizes many members of the family, including activin A, growth differentiation factor 11, and myostatin. The objective of this study was to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cca4342a16029d7f43cb7e1076db5e5
https://pubmed.ncbi.nlm.nih.gov/24627466
https://pubmed.ncbi.nlm.nih.gov/24627466
Autor:
Andrew L. Glasebrook, Lorri L. Short, Harlan W. Cole, Ellen R. Rowley, James P. Sluka, David Lynn Phillips, Venugopalan M, Fuson Tr, Magee David Edward, Lewis D. Pennington, Na N. Yang, Masahiko Sato, Adrian, Timothy Alan Grese, Henry Uhlman Bryant, Pamela K. Shetler
Publikováno v:
Journal of Medicinal Chemistry. 41:1272-1283
The 2-arylbenzothiophene raloxifene, 1, is a selective estrogen receptor modulator (SERM) which is currently under clinical evaluation for the prevention and treatment of postmenopausal osteoporosis. In vivo structure-activity relationships and molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d5c642a524dc3cabeb566fedaf2674
https://doi.org/10.1021/jm970688z
https://doi.org/10.1021/jm970688z