Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Pamela J. Sykes"'
Autor:
Pamela J. Sykes
Publikováno v:
Dose-Response, Vol 18 (2020)
Current regulation of ionizing radiation is based on the linear no-threshold (LNT) model where any radiation dose increases cancer risk and is independent of dose rate, resulting in large amounts of time and money being spent protecting from extremel
Externí odkaz:
https://doaj.org/article/88d1b9806e284a5dbc30acd229b1c3cd
Publikováno v:
Dose-Response, Vol 5 (2007)
The pKZ1 mouse chromosomal inversion assay is the only assay that has detected modulation of a mutagenic endpoint after single whole body X-irradiation with doses lower than 1 mGy. A non-linear dose response for chromosomal inversion has been observe
Externí odkaz:
https://doaj.org/article/bcdaaeab8e04416ab0163cb2f3fd23c6
Requirements for Identification of Low Dose and Non-Linear Mutagenic Responses to Ionising Radiation
Autor:
Pamela J. Sykes, Tanya K. Day
Publikováno v:
Dose-Response, Vol 5 (2007)
Cancer results from multiple changes in gene expression that can occur both genetically and epigenetically. High doses of radiation can lead to mutations and cancer. At high doses the number of mutations caused by radiation is essentially linear with
Externí odkaz:
https://doaj.org/article/f16593327ea444ff9ce48ea0fb46f592
Autor:
Pamela J. Sykes, Tanya K. Day, Sarah J. Swinburne, Joanne M. Lane, Alexander A. Morley, Antony M. Hooker, Madhava Bhat
Publikováno v:
Dose-Response, Vol 4 (2006)
Almost all of our knowledge about the mutational effect of radiation has come from high dose studies which are generally not relevant to public exposure. The pKZ1 mouse recombination mutagenesis assay enables study of the mutational effect of very lo
Externí odkaz:
https://doaj.org/article/cfe9076ec03f4574a68c8b91617edf04
Autor:
Pamela J. Sykes, Karen M. Lower, Michael Z. Michael, Rebecca J. Ormsby, Katherine L. Morel, Margaret M. Centenera, Lisa M. Butler, Ganessan Kichenadasse, Linh N.K. Tran
Legends of supplementary Figure S1, S2, S3, S4, and S5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584ca8dcceed6ff38e64b980fd1cadf9
https://doi.org/10.1158/1535-7163.22509328.v1
https://doi.org/10.1158/1535-7163.22509328.v1
Autor:
Pamela J. Sykes, Karen M. Lower, Michael Z. Michael, Rebecca J. Ormsby, Katherine L. Morel, Margaret M. Centenera, Lisa M. Butler, Ganessan Kichenadasse, Linh N.K. Tran
S1: Comparison of the Incucyte FLR and Operetta High Content Imaging System for detection of apoptosis in PC-3 cells induced by Paclitaxel. S2: Nuclear fragmentation index of PC-3 cells in the presence and absence of ectopically expressed p53 in resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45bebf94f21d7419116501156db2ecf
https://doi.org/10.1158/1535-7163.22509325
https://doi.org/10.1158/1535-7163.22509325
Publikováno v:
Current Cancer Drug Targets. 19:368-381
Prostate cancer (PCa) is the most frequent cancer in men. The evolution from local PCa to castration-resistant PCa, an end-stage of disease, is often associated with changes in genes such as p53, androgen receptor, PTEN, and ETS gene fusion products.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e358cdfdeef670e5b59335f5b81350c6
https://doi.org/10.2174/1568009618666180724111604
https://doi.org/10.2174/1568009618666180724111604
Autor:
Michelle R Newman, Pamela J Sykes, Benjamin J Blyth, Eva Bezak, Mark D Lawrence, Katherine L Morel, Rebecca J Ormsby
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e93016 (2014)
The low dose radioadaptive response has been shown to be protective against high doses of radiation as well as aging-induced genomic instability. We hypothesised that a single whole-body exposure of low dose radiation would induce a radioadaptive res
Externí odkaz:
https://doaj.org/article/10f73dd7fbf6424fbe5b968e2d02ddb6
Autor:
Katherine L. Morel, Tina C Lavranos, Sonja Klebe, David J. Elliot, Linh Tran, Karen M. Lower, Rebecca J. Ormsby, Pamela J. Sykes, Ganessan Kichenadasse
Publikováno v:
In Vivo. 33:99-108
Background/aim The hypoglycemic drug metformin (MET) and the anti-epileptic drug valproic acid (VPA) have individually shown anti-tumor effects in prostate cancer in vitro. The present study intended to investigate the efficacy of the combination of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1b8bdd9e7e9091719c10eef20df1485
https://doi.org/10.21873/invivo.11445
https://doi.org/10.21873/invivo.11445
Autor:
Pamela J. Sykes
Publikováno v:
Australasian Physical & Engineering Sciences in Medicine. 39:807-811
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c70b2d54f17d524da0241b833c5d91
https://doi.org/10.1007/s13246-016-0486-2
https://doi.org/10.1007/s13246-016-0486-2