Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Pamela J. McMillan"'
Autor:
Sarah M. Waldherr, Marina Han, Aleen D. Saxton, Taylor A. Vadset, Pamela J. McMillan, Jeanna M. Wheeler, Nicole F. Liachko, Brian C. Kraemer
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-19 (2024)
Abstract Pathological tau disrupts protein homeostasis (proteostasis) within neurons in Alzheimer’s disease (AD) and related disorders. We previously showed constitutive activation of the endoplasmic reticulum unfolded protein response (UPRER) tran
Externí odkaz:
https://doaj.org/article/1dbc62a4684b4673b78505934d8b0d3a
Autor:
Pamela J. McMillan, Timothy J. Strovas, Misa Baum, Brooke K. Mitchell, Randall J. Eck, Nzinga Hendricks, Jeanna M. Wheeler, Caitlin S. Latimer, C. Dirk Keene, Brian C. Kraemer
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-14 (2021)
Abstract Several conserved nuclear RNA binding proteins (sut-1, sut-2, and parn-2) control tau aggregation and toxicity in C. elegans, mice, and human cells. MSUT2 protein normally resides in nuclear speckles, membraneless organelles composed of phas
Externí odkaz:
https://doaj.org/article/dd6cabf3bab6402eb83b0235389e890a
Autor:
Rebecca L. Kow, Timothy J. Strovas, Pamela J. McMillan, Ashley M. Jacobi, Mark A. Behlke, Aleen D. Saxton, Caitlin S. Latimer, C. Dirk Keene, Brian C. Kraemer
Publikováno v:
Neurobiology of Disease, Vol 147, Iss , Pp 105148- (2021)
Aging drives pathological accumulation of proteins such as tau, causing neurodegenerative dementia disorders like Alzheimer's disease. Previously we showed loss of function mutations in the gene encoding the poly(A) RNA binding protein SUT-2/MSUT2 su
Externí odkaz:
https://doaj.org/article/a306260c5f1f44a8881453e339558866
Autor:
Laura M. Taylor, Pamela J. McMillan, Nicole F. Liachko, Timothy J. Strovas, Bernardino Ghetti, Thomas D. Bird, C. Dirk Keene, Brian C. Kraemer
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-14 (2018)
Abstract Background Progressive neuron loss in the frontal and temporal lobes of the cerebral cortex typifies frontotemporal lobar degeneration (FTLD). FTLD sub types are classified on the basis of neuronal aggregated protein deposits, typically cont
Externí odkaz:
https://doaj.org/article/cb8c39a403ef46ad9d433dc7509a0fcb
Autor:
Pamela J McMillan, Sarah J Benbow, Rikki Uhrich, Aleen Saxton, Misa Baum, Timothy Strovas, Jeanna M Wheeler, Jeremy Baker, Nicole F Liachko, C Dirk Keene, Caitlin S Latimer, Brian C Kraemer
Publikováno v:
Brain.
Alzheimer’s disease and related disorders feature neurofibrillary tangles and other neuropathological lesions composed of detergent-insoluble tau protein. In recent structural biology studies of tau proteinopathy, aggregated tau forms a distinct se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47843d8b278e436d7b7a20a0a9960cac
https://doi.org/10.1093/brain/awad032
https://doi.org/10.1093/brain/awad032
Autor:
Brooke K. Mitchell, Randall J. Eck, Timothy J. Strovas, Jeanna M. Wheeler, Misa Baum, Nzinga Hendricks, Caitlin S. Latimer, Brian C. Kraemer, C. Dirk Keene, Pamela J. McMillan
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-14 (2021)
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-14 (2021)
Several conserved nuclear RNA binding proteins (sut-1, sut-2, and parn-2) control tau aggregation and toxicity in C. elegans, mice, and human cells. MSUT2 protein normally resides in nuclear speckles, membraneless organelles composed of phase-separat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::080d0225ce494f7f8c02ef9a56f81a28
https://pubmed.ncbi.nlm.nih.gov/34187600
https://pubmed.ncbi.nlm.nih.gov/34187600
Autor:
Rachel E. Gatlin, C. Dirk Keene, Nicole F. Liachko, Brian C. Kraemer, Laura Taylor, Jeanna M. Wheeler, Caitlin S. Latimer, Timothy J. Strovas, Pamela J. McMillan, Thomas D. Bird, Misa Baum
Publikováno v:
Acta Neuropathologica Communications
The kinase TTBK1 is predominantly expressed in the central nervous system and has been implicated in neurodegenerative diseases including Alzheimer’s disease, frontotemporal lobar degeneration, and amyotrophic lateral sclerosis through its ability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d45971d687847d84c4d0d7bcbaeb25fe
http://europepmc.org/articles/PMC7684928
http://europepmc.org/articles/PMC7684928
Autor:
Pamela J. McMillan, Aleen D. Saxton, Mark A. Behlke, Timothy J. Strovas, Rebecca L. Kow, Brian C. Kraemer, Ashley M. Jacobi, C. Dirk Keene, Caitlin S. Latimer
Publikováno v:
Neurobiology of disease
Neurobiology of Disease, Vol 147, Iss, Pp 105148-(2021)
Neurobiology of Disease, Vol 147, Iss, Pp 105148-(2021)
Aging drives pathological accumulation of proteins such as tau, causing neurodegenerative dementia disorders like Alzheimer's disease. Previously we showed loss of function mutations in the gene encoding the poly(A) RNA binding protein SUT-2/MSUT2 su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231b90f0f8921e9852fbc349ef8dbabd
https://pubmed.ncbi.nlm.nih.gov/33184027
https://pubmed.ncbi.nlm.nih.gov/33184027
Autor:
Timothy J. Strovas, Aleen D. Saxton, C. Dirk Keene, Gerard D. Schellenberg, Chris R. Guthrie, Brian C. Kraemer, John Q. Trojanowski, Pamela J. McMillan, Linda C. Robinson, Nicholas M. Kanaan, Murray A. Raskind, Jeanna M. Wheeler, Li-San Wang, Nicole F. Liachko, Elaine R. Peskind, Patricia Szot, Virginia M.-Y. Lee, Thomas D. Bird, Rebecca L. Kow, Alexandre Amlie-Wolf, Ronald Klein
Publikováno v:
Sci Transl Med
Brain lesions composed of pathological tau help to drive neurodegeneration in Alzheimer’s disease (AD) and related tauopathies. Here, we identified the mammalian suppressor of tauopathy 2 (MSUT2) gene as a modifier of susceptibility to tau toxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6425183692ee7e471b8d16fef6fc2f
https://doi.org/10.1126/scitranslmed.aao6545
https://doi.org/10.1126/scitranslmed.aao6545
Autor:
Pamela J. McMillan, C. Dirk Keene, Nicole F. Liachko, Brian C. Kraemer, Thomas D. Bird, Aleen D. Saxton, Timothy J. Strovas
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 15, Iss 12, p e1008526 (2019)
PLoS Genetics, Vol 15, Iss 12, p e1008526 (2019)
Pathological phosphorylated TDP-43 protein (pTDP) deposition drives neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP). However, the cellular and genetic mechanisms at work in pathological TDP-43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf8ed3b5e2c15922cfbe2afc4e59176
http://europepmc.org/articles/PMC6934317
http://europepmc.org/articles/PMC6934317