Rationale and Means to Target Pro-Inflammatory Interleukin-8 (CXCL8) Signaling in Cancer

Autor: Laura M. Campbell, Pamela J. Maxwell, David J.J. Waugh

Publikováno v: Pharmaceuticals, Vol 6, Iss 8, Pp 929-959 (2013)

It is well established that chronic inflammation underpins the development of a number of human cancers, with pro-inflammatory signaling within the tumor microenvironment contributing to tumor progression and metastasis. CXCL8 is an ELR+ pro-inflamma

Externí odkaz: https://doaj.org/article/d0e81b6b3ae5487aba5a2040c3b8f800

Data from Attenuating Adaptive VEGF-A and IL8 Signaling Restores Durable Tumor Control in AR Antagonist–Treated Prostate Cancers

Autor: David J.J. Waugh, Melissa J. LaBonte, Elena Deryugina, Johann S. de Bono, Amina Zoubeidi, James P. Quigley, Daniel B. Longley, Ian G. Mills, Jenny Worthington, Chee Wee Ong, Judith M. Manley, Christopher W. Armstrong, Melanie McKechnie, Pamela J. Maxwell

Inhibiting androgen signaling using androgen signaling inhibitors (ASI) remains the primary treatment for castrate-resistant prostate cancer. Acquired resistance to androgen receptor (AR)-targeted therapy represents a major impediment to durable clin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52427ad61685612c0bb082fcc4128ccc
https://doi.org/10.1158/1541-7786.c.6545405.v1

Clinical and functional characterization of CXCR1/CXCR2 biology in the relapse and radiotherapy resistance of primary PTEN-deficient prostate carcinoma

Autor: Kevin M. Prise, Chris Armstrong, David Waugh, Robert G. Bristow, Oksana Lyubomska, Suneil Jain, Chee Wee Ong, Karl T. Butterworth, Pamela J. Maxwell, Silvia Berlingeri, Jonathan A. Coulter, Steven Walker, Ian G. Mills, Melissa J. LaBonte, Rebecca Gallagher, Joe M O'Sullivan

Publikováno v: Nar Cancer
Armstrong, C W D, Coulter, J A, Ong, C W, Maxwell, P J, Walker, S, Butterworth, K T, Lyubomska, O, Berlingeri, S, Gallagher, R, O'Sullivan, J M, Jain, S, Mills, I G, Prise, K M, Bristow, R G, LaBonte, M J & Waugh, D J J 2020, ' Clinical and functional characterization of CXCR1/CXCR2 biology in the relapse and radiotherapy resistance of primary PTEN-deficient prostate carcinoma ', Familial Cancer, vol. 2, no. 3, pp. zcaa012 . https://doi.org/10.1093/narcan/zcaa012
Armstrong, C, Ong, C W, Maxwell, P, O'Sullivan, J, Prise, K, Butterworth, K, Coulter, J, Walker, S, Oksana, L, Gallagher, R, Jain, S, Bristow, R G, Mills, I, Waugh, D & LaBonte Wilson, M 2020, ' Clinical and functional characterization of CXCR1/CXCR2 biology in the relapse and radiotherapy resistance of primary PTEN-deficient prostate carcinoma ', NAR Cancer, vol. 2, no. 3, zcaa012 . https://doi.org/10.1093/narcan/zcaa012

Functional impairment of the tumour suppressor PTEN is common in primary prostate cancer and has been linked to relapse post-radiotherapy (post-RT). Pre-clinical modelling supports elevated CXC chemokine signalling as a critical mediator of PTEN-depl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86f9073468cc13afe50340314369da0
https://doi.org/10.1093/narcan/zcaa012

Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists

Autor: Christopher, McCann, Nyree, Crawford, Joanna, Majkut, Caitriona, Holohan, Chris W D, Armstrong, Pamela J, Maxwell, Chee Wee, Ong, Melissa J, LaBonte, Simon S, McDade, David J, Waugh, Daniel B, Longley

Publikováno v: Cell Death & Disease

Expression of tumor necrosis factor-α (TNFα) in the serum of prostate cancer patients is associated with poorer outcome and progression to castrate-resistant (CRPC) disease. TNFα promotes the activity of NFκB, which regulates a number of anti-apo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9a916e13f950c31329fff4c2b9ab4748
https://pubmed.ncbi.nlm.nih.gov/30349042

Rationale and Means to Target Pro-Inflammatory Interleukin-8 (CXCL8) Signaling in Cancer

Autor: David Waugh, Laura M. Campbell, Pamela J. Maxwell

Publikováno v: Pharmaceuticals, Vol 6, Iss 8, Pp 929-959 (2013)
Pharmaceuticals

It is well established that chronic inflammation underpins the development of a number of human cancers, with pro-inflammatory signaling within the tumor microenvironment contributing to tumor progression and metastasis. CXCL8 is an ELR+ pro-inflamma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c2fa35855c8e2c4e98484c215514095
http://www.mdpi.com/1424-8247/6/8/929