Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Pamela J. Kennedy"'
Autor:
Deena M. Walker, Xianxiao Zhou, Ashley M. Cunningham, Aarthi Ramakrishnan, Hannah M. Cates, Casey K. Lardner, Catherine J. Peña, Rosemary C. Bagot, Orna Issler, Yentl Van der Zee, Andrew P. Lipschultz, Arthur Godino, Caleb J. Browne, Georgia E. Hodes, Eric M. Parise, Angelica Torres-Berrio, Pamela J. Kennedy, Li Shen, Bin Zhang, Eric J. Nestler
Publikováno v:
Biological psychiatry. 92(11)
Social experiences influence susceptibility to substance use disorder. The adolescent period is associated with the development of social reward and is exceptionally sensitive to disruptions to reward-associated behaviors by social experiences. Socia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3fb8f9c03f95e552738d09bc411f52
https://pubmed.ncbi.nlm.nih.gov/36182529
https://pubmed.ncbi.nlm.nih.gov/36182529
Autor:
Yoko H Ohnishi, Yoshinori N Ohnishi, Takanori Nakamura, Mizuki Ohno, Pamela J Kennedy, Yasuyuki Ohkawa, Akinori Nishi, Rachael Neve, Teruhisa Tsuzuki, Eric J Nestler
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131263 (2015)
Externí odkaz:
https://doaj.org/article/cef6a1a6509a4623ab916c18c3da8a9f
Autor:
Yoko H Ohnishi, Yoshinori N Ohnishi, Takanori Nakamura, Mizuki Ohno, Pamela J Kennedy, Yasuyuki Ohkawa, Akinori Nishi, Rachael Neve, Teruhisa Tsuzuki, Eric J Nestler
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126710 (2015)
ΔFosB is a stable transcription factor which accumulates in the nucleus accumbens (NAc), a key part of the brain's reward circuitry, in response to chronic exposure to cocaine or other drugs of abuse. While ΔFosB is known to heterodimerize with a J
Externí odkaz:
https://doaj.org/article/f35adf3d431441ac92fe72da446fc450
Publikováno v:
Hippocampus
Hippocampus, vol 29, iss 11
Hippocampus, vol 29, iss 11
The transition from recreational drug use to addiction involves pathological learning processes that support a persistent shift from flexible, goal‐directed to habit behavioral control. Here, we examined the molecular mechanisms supporting altered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec9c4a574c92fdc2bc509f30b4ad096
https://doi.org/10.1002/hipo.23127
https://doi.org/10.1002/hipo.23127
Autor:
Hannah M. Cates, Andrew P. Lipschultz, Li Shen, Georgia E. Hodes, Bin Zhang, Ashley M. Cunningham, Arthur Godino, Orna Issler, Yentl Y. van der Zee, Eric M. Parise, Aarthi Ramakrishnan, Catherine Jensen Pena, Angélica Torres-Berrío, Xianxiao Zhou, Eric J. Nestler, Deena M. Walker, Caleb J. Browne, Pamela J. Kennedy, Rosemary C. Bagot
Adolescence is a sensitive window for reward- and stress-associated behavior. Although stress during this period causes long-term changes in behavior in males, how females respond is relatively unknown. Here we show that social isolation stress in ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1001bd96871cd51f657ad232f844e66
https://doi.org/10.1101/2020.02.18.955187
https://doi.org/10.1101/2020.02.18.955187
Publikováno v:
Biol Psychiatry
BACKGROUND: Maintenance treatment with opioid agonists (buprenorphine, methadone) is effective for opioid addiction but does not eliminate opioid use in all patients. Here, we modeled maintenance treatment in rats that self-administered the prescript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd6e80260f60c66d536208ae3ff3f543
https://doi.org/10.1016/j.biopsych.2020.09.006
https://doi.org/10.1016/j.biopsych.2020.09.006
Autor:
Hannah M. Cates, Xuan Li, Pamela J. Kennedy, Yavin Shaham, Immanuel Purushothaman, Li Shen, Eric J. Nestler
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 43(12)
Methamphetamine (Meth) seeking progressively increases after withdrawal (incubation of Meth craving), but the transcriptional mechanisms that contribute to this incubation are unknown. Here we used RNA-sequencing to analyze transcriptional profiles a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b7920d3244ea51de33c67467afb1dd
https://pubmed.ncbi.nlm.nih.gov/30072726
https://pubmed.ncbi.nlm.nih.gov/30072726
Autor:
Megan Kechner, Basma S. Al Masraf, Alfred J. Robison, Andrew L. Eagle, Paula A. Gajewski, Hongbing Wang, Miyoung Yang, Pamela J. Kennedy, Michelle S. Mazei-Robison
Publikováno v:
The Journal of Neuroscience. 35:13773-13783
The hippocampus (HPC) is known to play an important role in learning, a process dependent on synaptic plasticity; however, the molecular mechanisms underlying this are poorly understood. ΔFosB is a transcription factor that is induced throughout the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf98bbaa916c5e20a7cd63904200765e
https://doi.org/10.1523/jneurosci.2083-15.2015
https://doi.org/10.1523/jneurosci.2083-15.2015
Autor:
Sam A. Golden, Erica Korb, Jacqui Rabkin, Rosemary C. Bagot, Elizabeth A. Heller, Hannah M. Cates, Carol A. Tamminga, Ning-Yi Shao, Ja Wook Koo, Gustavo Turecki, Li Shen, Diane M. Damez-Werno, Scott J. Russo, Benoit Labonté, Patrick Varga-Weisz, HaoSheng Sun, Caroline Dias, Kelly Gleason, Eric J. Nestler, Pamela J. Kennedy, Kimberly N. Scobie, Ezekiell Mouzon, Ian Maze, David M. Dietz, Francisca H. Ahn, Simon Andrews, C. David Allis, Michael E. Cahill, Rachael L. Neve
Publikováno v:
Nature medicine
Improved treatment for major depressive disorder (MDD) remains elusive because of the limited understanding of its underlying biological mechanisms. It is likely that stress-induced maladaptive transcriptional regulation in limbic neural circuits con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6880d235f88906040c23bda043e040af
https://doi.org/10.1038/nm.3939
https://doi.org/10.1038/nm.3939
Autor:
Pamela J. Kennedy, Eric Harvey
Publikováno v:
CNS & Neurological Disorders - Drug Targets. 14:764-772
Drug-induced changes in gene expression likely contribute to long-lasting structural and functional alterations in the brain's reward circuitry and the persistence of addiction. Modulation of chromatin structure through covalent histone modifications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7830cfbeb80a0bbd348670302bde0e
https://doi.org/10.2174/1871527314666150529144804
https://doi.org/10.2174/1871527314666150529144804