Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Pamela J. Focia"'
Autor:
Hiromi Watari, Hiromu Kageyama, Nami Masubuchi, Hiroya Nakajima, Kako Onodera, Pamela J. Focia, Takumi Oshiro, Takashi Matsui, Yoshio Kodera, Tomohisa Ogawa, Takeshi Yokoyama, Makoto Hirayama, Kanji Hori, Douglas M. Freymann, Misa Imai, Norio Komatsu, Marito Araki, Yoshikazu Tanaka, Ryuichi Sakai
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The mode of cytokine receptor activation is diverse. Here, the authors find that the marine-sponge derived lectin ThC, a bivalent sugar binding protein, activates human cytokine receptor MPL. This mode of action resembles the pathogenic activation of
Externí odkaz:
https://doaj.org/article/738b2a8a80c14fc9844ae3c420641088
Autor:
Marito Araki, Kako Onodera, Kanji Hori, Hiromu Kageyama, Pamela J. Focia, Hiromi Watari, Yoshio Kodera, Makoto Hirayama, Yoshikazu Tanaka, Ryuichi Sakai, Takeshi Yokoyama, Hiroya Nakajima, Douglas M. Freymann, Takashi Matsui, Norio Komatsu, Tomohisa Ogawa, Nami Masubuchi, Takumi Oshiro
N-glycan-mediated activation of the thrombopoietin receptor (MPL) under pathological conditions has been implicated in myeloproliferative neoplasms induced by mutant calreticulin, which forms an endogenous receptor-agonist complex that constitutively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4600ca3460eb1687989236b0b6b08774
https://doi.org/10.1101/2021.10.29.466502
https://doi.org/10.1101/2021.10.29.466502
Autor:
Pamela J. Focia, Peter H. Winegar, Chad A. Mirkin, C. Adrian Figg, Janet R. McMillan, Oliver G. Hayes
Publikováno v:
Chem
Designed DNA-DNA interactions are investigated for their ability to modulate protein packing within single crystals of mutant green fluorescent proteins (mGFPs) functionalized with a single DNA strand (mGFP-DNA). We probe the effects of DNA sequence,
Autor:
Kyle P. Smith, Eric C. Landahl, Douglas M. Freymann, Pamela J. Focia, Sarah E. Rice, Julian L. Klosowiak, Srinivas Chakravarthy
Publikováno v:
J Struct Biol
Dysfunction in mitochondrial dynamics is believed to contribute to a host of neurological disorders and has recently been implicated in cancer metastasis. The outer mitochondrial membrane adapter protein Miro functions in the regulation of mitochondr
Publikováno v:
Biochemistry
Potassium channels allow for the passive movement of potassium ions across the cell membrane and are instrumental in controlling the membrane potential in all cell types. Quaternary ammonium (QA) compounds block potassium channels and have long been
Autor:
Srinivas Chakravarthy, Pamela J. Focia, Sarah E. Rice, Eric C. Landahl, Douglas M. Freymann, Julian L. Klosowiak
Publikováno v:
EMBO reports. 14:968-974
Miro is a highly conserved calcium-binding GTPase at the regulatory nexus of mitochondrial transport and autophagy. Here we present crystal structures comprising the tandem EF hand and carboxy terminal GTPase (cGTPase) domains of Drosophila Miro. The
Autor:
Michael E. French, Sungjin Park, Sarah E. Rice, Julian L. Klosowiak, Kyle P. Smith, Douglas M. Freymann, Pamela J. Focia
Publikováno v:
Scientific Reports
Hereditary Parkinson’s disease is commonly caused by mutations in the protein kinase PINK1 or the E3 ubiquitin ligase Parkin, which function together to eliminate damaged mitochondria. PINK1 phosphorylates both Parkin and ubiquitin to stimulate ubi
Autor:
Julian L. Klosowiak, Douglas M. Freymann, Pamela J. Focia, Yongbo Zhang, Kyle P. Smith, Sarah E. Rice
Publikováno v:
Biophysical Journal. 112:177a-178a
Mitochondria motility and dynamics are tightly linked. Dysfunction in mitochondrial dynamics cause a host of neurological disorders. The outer mitochondrial membrane protein Miro contains two GTPase domains that control mitochondrial dynamics. While
Autor:
Z. Sean Juo, Heli Liu, K. Christopher Garcia, Xiaoyan Chen, Pamela J. Focia, Ann Hye Ryong Shim, Xiaolin He
Publikováno v:
Cell. 142:749-761
SummaryRepulsive signaling by Semaphorins and Plexins is crucial for the development and homeostasis of the nervous, immune, and cardiovascular systems. Sema7A acts as both an immune and a neural Semaphorin through PlexinC1, and A39R is a Sema7A mimi
Publikováno v:
Biochemistry. 49:1486-1494
Electron spin-echo envelope modulation (ESEEM) spectroscopy is a well-established technique for the study of naturally occurring paramagnetic metal centers. The technique has been used to study copper complexes, hemes, enzyme mechanisms, micellar wat