Výsledky vyhledávání - "Pamela J. Flint"

Cyclooxygenase-2 Inhibition Does Not Improve the Reduction in Ductal Carcinoma In situ Proliferation with Aromatase Inhibitor Therapy: Results of the ERISAC Randomized Placebo-Controlled Trial

Autor: Andrew D Baildam, Pamela J. Flint, Kwok-Leung Cheung, Sue Grassby, Julie Morris, Göran Landberg, O. Young, Nigel J Bundred, Lorraine Turner, Lorna Renshaw, R. Johnson, A. Cramer, J Michael Dixon, Lester Barr

Publikováno v: Clinical Cancer Research. 16:1605-1612

Purpose: Tamoxifen reduces risk of recurrence after breast conservation surgery for ductal carcinoma in situ (DCIS), but no data exists on the effectiveness of aromatase inhibitors for DCIS. Cyclooxygenase-2 (COX-2) is overexpressed in DCIS, represen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979e61252af4239e7e3162c621d45270
https://doi.org/10.1158/1078-0432.ccr-09-1623

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Survivin expression in in situ and invasive breast cancer relates to COX-2 expression and DCIS recurrence

Autor: Nicola Barnes, Nigel J Bundred, W F Knox, Pamela J. Flint, P Haywood

Publikováno v: British Journal of Cancer

In lung cancer cyclooxygenase-2 (COX-2) expression has been reported to stabilise survivin, an inhibitor of apoptosis (IAP) which prevents cell death by blocking activated caspases. COX-2 expression limits the ubiquitination of survivin, protecting i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7852b6aec8a8b6480b80607bac4df43
https://doi.org/10.1038/sj.bjc.6602932

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