Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Pamela J. Beck"'
Publikováno v:
European Journal of Biochemistry. 268:3767-3773
A systematic study of the oxidative folding of murine prion protein mPrP(23‐231) is reported here. Folding of mPrP(23‐231) involves formation of a single disulfide bond, Cys179‐Cys214. Despite this simplicity, reduced mPrP(23‐231) exhibits nu
Publikováno v:
Journal of Biological Chemistry. 274:5271-5278
Synthetic carbohydrate and glycoprotein mimics displaying sulfated saccharide residues have been assayed for their L-selectin inhibitory properties under static and flow conditions. Polymers displaying the L-selectin recognition epitopes 3',6-disulfo
Publikováno v:
Tetrahedron. 53:11937-11952
The selectin class of proteins plays an important role in the inflammatory response. These proteins, which bind saccharide ligands, facilitate the recruitment of leukocytes to the inflamed endothelium. The ring-opening metathesis polymerization (ROMP
Autor:
Karin Keller, B. Dupre, R. V. Market, Scott Ian L, Huong Bui, Pamela J. Beck, Timothy P. Kogan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:569-572
A novel class of biphenyl-based compounds were investigated for their ability to inhibit sialyl Lewis X (sLex) dependent binding of HL-60 cells to E- and P-selectin fusion proteins. Compounds ( 2b ) and ( 2h ) demonstrated improved binding as compare
Publikováno v:
Journal of Biological Chemistry. 271:4289-4297
P-selectin is a vascular cell adhesion molecule that is expressed on the surface of platelets and endothelial cells in response to inflammatory stimuli. It is believed to aid in the binding and recruitment of leukocytes to inflamed tissue. P-selectin
Autor:
Scott Ian L, Karin Keller, Huong Bui, B. M. Revelle, Timothy P. Kogan, B. Dupre, J. A. Voytus, Pamela J. Beck, D. Scott, R. V. Market
Publikováno v:
Journal of Medicinal Chemistry. 38:4976-4984
The calcium dependent E-selectin/sialyl Lewisx (sLex) interaction plays a key role in inflammation where it mediates the rolling of leukocytes prior to firm adhesion and extravasation from the vasculature. A model of E-selectin/sLex binding, along wi
Publikováno v:
ChemInform. 28
The selectin class of proteins plays an important role in the inflammatory response. These proteins, which bind saccharide ligands, facilitate the recruitment of leukocytes to the inflamed endothelium. The ring-opening metathesis polymerization (ROMP
Autor:
Scott Ian L, P. Vanderslice, B. Dupre, R. A. F. Dixon, Timothy P. Kogan, Kassir Jamal M, Xin Hu, Huong Bui, K. L. Mcabee, Pamela J. Beck
Publikováno v:
ChemInform. 29
Autor:
Timothy P. Kogan, Scott Ian L, Ashfaq Ahmed, Robert J. Bjercke, Xiaofeng Hu, Edward T.H. Yeh, Richard A. F. Dixon, Pamela J. Beck, B. Mitch Revelle, Yelena Botvinnikova, Isabel T. Lauredo, Juan R. Sabater, William M. Abraham
Publikováno v:
American journal of respiratory and critical care medicine. 159(4 Pt 1)
Antigen challenge can elicit an allergic inflammatory response in the airways that involves eosinophils, basophils, and neutrophils and that is expressed physiologically as a late airway response (LAR) and airway hyperresponsiveness (AHR). Although p
Autor:
Kathy L. McAbee, Scott Ian L, Timothy P. Kogan, Brian Dupre, Xin Hu, Kassir Jamal M, Peter Vanderslice, Richard A. F. Dixon, Huong Bui, Pamela J. Beck
Publikováno v:
Journal of medicinal chemistry. 41(7)
Reports of a high-affinity ligand for E-selectin, sialyl di-Lewis(x) (sLe(x)Le(x), 1), motivated us to incorporate modifications to previously reported biphenyl-based inhibitors that would provide additional interactions with the protein. These compo