Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Pamela J McLean"'
Autor:
Kshama Gupta, Ralph B. Perkerson, Tammee M. Parsons, Ramacharan Angom, Danilyn Amerna, Jeremy D. Burgess, Yingxue Ren, Pamela J. McLean, Debabrata Mukhopadhyay, Prasanna Vibhute, Zbigniew K. Wszolek, Abba C. Zubair, Alfredo Quiñones-Hinojosa, Takahisa Kanekiyo
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Background Radiation therapy is the standard of care for central nervous system tumours. Despite the success of radiation therapy in reducing tumour mass, irradiation (IR)-induced vasculopathies and neuroinflammation contribute to late-delay
Externí odkaz:
https://doaj.org/article/24c38dbdcbff4be1bdca3df216a51ac3
A rapid, semi-quantitative assay to screen for modulators of alpha-synuclein oligomerization ex vivo
Autor:
Marion eDelenclos, Teodora eTrendafilova, Daryl R Jones, Simon eMoussaud, Ann Marie eBaine, Mei eYue, Warren D Hirst, Pamela J McLean
Publikováno v:
Frontiers in Neuroscience, Vol 9 (2016)
Alpha synuclein (αsyn) aggregates are associated with the pathogenesis of Parkinson’s disease and others related disorders. Although modulation of αsyn aggregation is an attractive therapeutic target, new powerful methodologies are desperately ne
Externí odkaz:
https://doaj.org/article/36f24f5922ca4f87941ffdef1124687b
Autor:
Zeynep Bengisu Kaya, Valeria Santiago-Padilla, Melina Lim, Suelen L. Boschen, Pergin Atilla, Pamela J. McLean
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract In the quest to unravel the mysteries of neurological diseases, comprehending the underlying mechanisms is supreme. The SH-SY5Y human neuroblastoma cell line serves as a crucial tool in this endeavor; however, the cells are known for its sen
Externí odkaz:
https://doaj.org/article/bf6899b7df964e3c813f8057e1206b9b
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92098 (2014)
Parkinson's disease is a neurodegenerative disorder characterized by Lewy bodies, a pathological hallmark comprised mostly of aggregated alpha synuclein. Accumulating evidence demonstrates the association of smaller oligomeric aggregates to disease e
Externí odkaz:
https://doaj.org/article/dee3e3b4dd7e4f65acf6ea5d3b17cf92
Autor:
Nikolaus R McFarland, Hemi Dimant, Laura Kibuuka, Darius Ebrahimi-Fakhari, Cody A Desjardins, Karin M Danzer, Michael Danzer, Zhanyun Fan, Michael A Schwarzschild, Warren Hirst, Pamela J McLean
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86048 (2014)
Hsp90 inhibitors such as geldanamycin potently induce Hsp70 and reduce cytotoxicity due to α-synuclein expression, although their use has been limited due to toxicity, brain permeability, and drug design. We recently described the effects of a novel
Externí odkaz:
https://doaj.org/article/c78d459ac5334556a26f1b1a94649c90
Autor:
Jeremy D. Burgess, Danilyn Amerna, Emily S. Norton, Tammee M. Parsons, Ralph B. Perkerson, Ayman H. Faroqi, Zbigniew K. Wszolek, Hugo Guerrero Cazares, Takahisa Kanekiyo, Marion Delenclos, Pamela J. McLean
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Background Mesenchymal stromal cells (MSCs) have a dynamic secretome that plays a critical role in tissue repair and regeneration. However, studying the MSC secretome in mixed-culture disease models remains challenging. This study aimed to d
Externí odkaz:
https://doaj.org/article/26b95de1f2774f8b9a09c407294b15bf
Autor:
Lorraine V Kalia, Suneil K Kalia, Hien Chau, Andres M Lozano, Bradley T Hyman, Pamela J McLean
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e14695 (2011)
Parkinson's disease (PD) is a common neurodegenerative condition in which abnormalities in protein homeostasis, or proteostasis, may lead to accumulation of the protein α-synuclein (α-syn). Mutations within or multiplications of the gene encoding
Externí odkaz:
https://doaj.org/article/555262e0a04c497faca4870861eead7e
Autor:
Vivek K Unni, Tamily A Weissman, Edward Rockenstein, Eliezer Masliah, Pamela J McLean, Bradley T Hyman
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10589 (2010)
Regulation of alpha-synuclein levels within cells is thought to play a critical role in Parkinson's Disease (PD) pathogenesis and in other related synucleinopathies. These processes have been studied primarily in reduced preparations, including cell
Externí odkaz:
https://doaj.org/article/8fc8346da91c46eebaaa43ecaae1abb2
Autor:
Tiago F Outeiro, Jochen Klucken, Kathryn Bercury, Julie Tetzlaff, Preeti Putcha, Luis M A Oliveira, Alexandre Quintas, Pamela J McLean, Bradley T Hyman
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e6906 (2009)
Oligomerization and aggregation of alpha-synuclein molecules play a major role in neuronal dysfunction and loss in Parkinson's disease [1]. However, alpha-synuclein oligomerization and aggregation have mostly been detected indirectly in cells using d
Externí odkaz:
https://doaj.org/article/83ed2a47e6c6447f8709de53d5c6309f
Autor:
Tiago Fleming Outeiro, Preeti Putcha, Julie E Tetzlaff, Robert Spoelgen, Mirjam Koker, Filipe Carvalho, Bradley T Hyman, Pamela J McLean
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e1867 (2008)
Misfolding, oligomerization, and fibrillization of alpha-synuclein are thought to be central events in the onset and progression of Parkinson's disease (PD) and related disorders. Although fibrillar alpha-synuclein is a major component of Lewy bodies
Externí odkaz:
https://doaj.org/article/b569cc7153d54f5ab0860498cc320da9