Zobrazeno 1 - 10
of 291
pro vyhledávání: '"Pamela J, Russell"'
Autor:
Jacqui A. McGovern, Nathalie Bock, Abbas Shafiee, Laure C. Martine, Ferdinand Wagner, Jeremy G. Baldwin, Marietta Landgraf, Christoph A. Lahr, Christoph Meinert, Elizabeth D. Williams, Pamela M. Pollock, Jim Denham, Pamela J. Russell, Gail P. Risbridger, Judith A. Clements, Daniela Loessner, Boris M. Holzapfel, Dietmar W. Hutmacher
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
McGovern et al. establish an orthotopic, humanized prostate cancer model to study bone metastasis. The authors demonstrate that a humanized tumor microenvironment (TME) influences the metastatic spread of cancer cells to tissue-engineered bone, highl
Externí odkaz:
https://doaj.org/article/faf5250036f045d891a483661ad13556
Autor:
Mei-Chun Yeh, Brian W. C. Tse, Nicholas L. Fletcher, Zachary H. Houston, Maria Lund, Marianna Volpert, Chelsea Stewart, Kamil A. Sokolowski, Varinder Jeet, Kristofer J. Thurecht, Douglas H. Campbell, Bradley J. Walsh, Colleen C. Nelson, Pamela J. Russell
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Purpose Chimeric antibody Miltuximab®, a human IgG1 engineered from the parent antibody MIL-38, is in clinical development for solid tumour therapy. Miltuximab® targets glypican-1 (GPC-1), a cell surface protein involved in tumour growth,
Externí odkaz:
https://doaj.org/article/2ef2c8e3d8664d7a8617ef5010ba309f
Autor:
Kieran F. Scott, Timothy J. Mann, Shadma Fatima, Mila Sajinovic, Anshuli Razdan, Ryung Rae Kim, Adam Cooper, Aflah Roohullah, Katherine J. Bryant, Kasuni K. Gamage, David G. Harman, Fatemeh Vafaee, Garry G. Graham, W. Bret Church, Pamela J. Russell, Qihan Dong, Paul de Souza
Publikováno v:
Molecules, Vol 26, Iss 23, p 7267 (2021)
Phospholipase A2 (PLA2) enzymes were first recognized as an enzyme activity class in 1961. The secreted (sPLA2) enzymes were the first of the five major classes of human PLA2s to be identified and now number nine catalytically-active structurally hom
Externí odkaz:
https://doaj.org/article/eb2e06cdc5944953ae3c4aad2d98fc41
Supplementary Data from Cytosine Deaminase-Uracil Phosphoribosyltransferase and Interleukin (IL)-12 and IL-18: A Multimodal Anticancer Interface Marked by Specific Modulation in Serum Cytokines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf917b50ff3276de49c152891f6cccb
https://doi.org/10.1158/1078-0432.22440049.v1
https://doi.org/10.1158/1078-0432.22440049.v1
Purpose: To test the effects of a new combination, cytosine deaminase (CD) + uracil phosphoribosyltransferase (UPRT)–mediated gene-directed enzyme prodrug therapy (GDEPT) with interleukin (IL)-12 and IL-18, on (a) growth of murine prostate and remo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40deafae4837238c9b72b6cd6d2fbb05
https://doi.org/10.1158/1078-0432.c.6517426
https://doi.org/10.1158/1078-0432.c.6517426
Autor:
Pamela J. Russell, Bradley J. Walsh, Brian W.C. Tse, Mei-Chun Yeh, Varinder Jeet, Douglas Campbell, Nicholas L. Fletcher, Marianna Volpert, Chelsea Stewart, Maria E. Lund, Kristofer J. Thurecht, Kamil A. Sokolowski, Colleen C. Nelson, Zachary H. Houston
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-13 (2020)
EJNMMI Research
EJNMMI Research
PurposeChimeric antibody Miltuximab®, a human IgG1 engineered from the parent antibody MIL-38, is in clinical development for solid tumour therapy. Miltuximab® targets glypican-1 (GPC-1), a cell surface protein involved in tumour growth, which is o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba38dacb09cb2ec4ef0eabe2e265cd5d
http://link.springer.com/article/10.1186/s13550-020-00637-x
http://link.springer.com/article/10.1186/s13550-020-00637-x
Autor:
Fatemeh Vafaee, Kasuni K. Gamage, Shadma Fatima, Ryung Rae Kim, Kieran F. Scott, Pamela J. Russell, Katherine Bryant, Garry G. Graham, David G. Harman, Aflah Roohullah, W. Bret Church, Anshuli Razdan, Qihan Dong, Adam Cooper, Paul de Souza, Timothy J. Mann, Mila Sajinovic
Publikováno v:
Molecules
Molecules, Vol 26, Iss 7267, p 7267 (2021)
Molecules, Vol 26, Iss 7267, p 7267 (2021)
Phospholipase A2 (PLA2) enzymes were first recognized as an enzyme activity class in 1961. The secreted (sPLA2) enzymes were the first of the five major classes of human PLA2s to be identified and now number nine catalytically-active structurally hom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b5db7547abe11bd2a280b471bdde81
http://europepmc.org/articles/PMC8658914
http://europepmc.org/articles/PMC8658914
Autor:
Kate Vandyke, Melanie Y. White, Terry Nguyen-Khuong, Kim Ow, Sharon C.-W. Luk, Elizabeth A. Kingsley, Alexandra Rowe, Shiu-Fun Pang, Bradley J. Walsh, Pamela J. Russell
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 4, Pp 322-331 (2007)
Few treatment options exist for metastatic prostate cancer (PC) that becomes hormone refractory (HRPC). In vitro, plant-derived MINA-05 caused dose-dependent decreases in cell numbers in HRPC cell lines LNCaPC4-2B and PC-3, and in androgen-sensitive
Externí odkaz:
https://doaj.org/article/d3b383c86af24a0582ad94cf736057d0
Autor:
Yasmin Husaini, Glen P Lockwood, Trung V Nguyen, Vicky Wang-Wei Tsai, Mohammad G Mohammad, Pamela J Russell, David A Brown, Samuel N Breit
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0115189 (2015)
The divergent TGF-β superfamily member, macrophage inhibitory cytokine-1 (MIC-1/GDF15), is overexpressed by most cancers, including prostate cancer (PCa). Whilst its circulating levels are linked to cancer outcome, the role MIC-1/GDF15 plays in canc
Externí odkaz:
https://doaj.org/article/2be7ba62d1c4450bbace7239dda15025
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0125641 (2015)
Externí odkaz:
https://doaj.org/article/23729296c86047ef92d2d165023955a7