Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Pamela J, Hornby"'
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 6, Pp n/a-n/a (2019)
Abstract Monoclonal antibodies (mAbs) have emerged as a major class of therapeutic agents on the market. To date, approximately 80 mAbs have been granted marketing approval. In 2018, 12 new mAbs were approved by the FDA, representing 20% of the total
Externí odkaz:
https://doaj.org/article/7155363f6e954bbd97f1a634f0fab4b8
Autor:
Pamela J. Hornby, J. Matthew Hinkley, Donghai Zheng, Walter J. Pories, Benjamin A. Kugler, James Lenhard, G. Lynis Dohm, Kai Zou, Terry E. Jones, Kristen Turner, Joseph A. Houmard
Publikováno v:
Am J Physiol Cell Physiol
The purpose of this study was to determine whether intramyocellular glucose partitioning was altered in primary human myotubes derived from severely obese women with type 2 diabetes. Human skeletal muscle cells were obtained from lean nondiabetic and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d599115bacd5dc9a3b83a49e4e3307b5
https://doi.org/10.1152/ajpcell.00157.2020
https://doi.org/10.1152/ajpcell.00157.2020
The metabolism of dietary tryptophan occurs locally in the gut primarily via host enzymes, with similar to 5% metabolized by gut microbes. Three major tryptophan metabolic pathways are serotonin (beyond the scope of this review), indole, kynurenine a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec7e10910b970c631edbf2d7a3a7981
https://hdl.handle.net/10468/12531
https://hdl.handle.net/10468/12531
Publikováno v:
Amino acids. 54(1)
The metabolism of dietary tryptophan occurs locally in the gut primarily via host enzymes, with ~ 5% metabolized by gut microbes. Three major tryptophan metabolic pathways are serotonin (beyond the scope of this review), indole, kynurenine and relate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::344fcb18990888d59d1f5851dab96467
https://pubmed.ncbi.nlm.nih.gov/35038025
https://pubmed.ncbi.nlm.nih.gov/35038025
Autor:
Philip R Cooper, Connie M Kliwinski, Robert A Perkinson, Edwin eRagwan, John R Mabus, Gordon D Powers, Haimanti eDorai, Jill eGiles-Komar, Pamela J Hornby
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
The neonatal Fc Receptor (FcRn) in intestinal epithelium is the primary mechanism for transfer of maternal immunoglobulin G (IgG) from suckled milk to serum; but the factors contributing to the rapid uptake of IgG are poorly understood. These studies
Externí odkaz:
https://doaj.org/article/2327a11d888e4eabac9b6f87c73238a9
Autor:
Amanda L Kauffman, Alexandra V Gyurdieva, John R Mabus, Chrissa eFerguson, Zhengyin eYan, Pamela J Hornby
Publikováno v:
Frontiers in Pharmacology, Vol 4 (2013)
Physiologically relevant sources of absorptive intestinal epithelial cells are crucial for human drug transport studies. Human adenocarcinoma-derived intestinal cell lines, such as Caco-2, offer conveniences of easy culture maintenance and scalabilit
Externí odkaz:
https://doaj.org/article/00e393261a4e4fc1bb0ba81ceef356b0
Autor:
James Lenhard, Donghai Zheng, Terry E. Jones, Kai Zou, J. Matthew Hinkley, Sanghee Park, G. Lynis Dohm, Walter J. Pories, Pamela J. Hornby, Joseph A. Houmard
Publikováno v:
International Journal of Obesity. 43:895-905
The partitioning of glucose toward glycolytic end products rather than glucose oxidation and glycogen storage is evident in skeletal muscle with severe obesity and type 2 diabetes. The purpose of the present study was to determine the possible mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346b61f1d9db771bd2cba46442f62fc9
https://doi.org/10.1038/s41366-018-0137-7
https://doi.org/10.1038/s41366-018-0137-7
Autor:
Edward S Kimball, Nathaniel K Wallace, Craig R Schneider, Michael R D'Andrea, Pamela J Hornby
Publikováno v:
Frontiers in Pharmacology, Vol 1 (2010)
Cannabinoids are known to be clinically beneficial for control of appetite disorders and nausea/vomiting, with emerging data that they can impact other GI disorders, such as inflammation. Post-inflammatory irritable bowel syndrome (PI-IBS) is a condi
Externí odkaz:
https://doaj.org/article/66aa94fe1daa48fcbf1ce536a1f44816
Autor:
Heather A. Redstone, William D. Buie, David A. Hart, Laurie Wallace, Pamela J. Hornby, Sarah Sague, Jen J. Holst, David L. Sigalet
Publikováno v:
Gastroenterology Research and Practice, Vol 2010 (2010)
Background. Glucagon-like peptide 2 (GLP-2) is an intestinal specific trophic hormone, with therapeutic potential; the effects on intestinal healing are unknown. We used a rat model of colonic healing, under normoxic, and stress (hypoxic) conditions
Externí odkaz:
https://doaj.org/article/bfba09dc4f3b42cc88bb2dac23b8dc84
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 6, Pp n/a-n/a (2019)
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives
Monoclonal antibodies (mAbs) have emerged as a major class of therapeutic agents on the market. To date, approximately 80 mAbs have been granted marketing approval. In 2018, 12 new mAbs were approved by the FDA, representing 20% of the total number o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7cb6f83d407c44236dc9cdaccca88d8
https://doaj.org/article/7155363f6e954bbd97f1a634f0fab4b8
https://doaj.org/article/7155363f6e954bbd97f1a634f0fab4b8