Výsledky vyhledávání - "Pamela Ghioni"

The Protein Stability and Transcriptional Activity of p63α are Regulated by SUMO-1 Conjugation

Autor: Girolama La Mantia, Gelsomina Mansueto, Ronald T. Hay, Pamela Ghioni, Yuri D'Alessandra, Luisa Guerrini, Ellis Jaffray

Publikováno v: Cell Cycle. 4:183-190

Post-translational modification of proteins by the ubiquitin-like molecule SUMO-1 regulates their stability and activity with crucial implications for many cellular processes. Here we show that p63alpha, but not p63beta and gamma, is sumoylated in vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309ff1248842cc9a11e61e0552fc74ac
https://doi.org/10.4161/cc.4.1.1359

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Inhibition of p63 Transcriptional Activity by p14ARF: Functional and Physical Link between Human ARF Tumor Suppressor and a Member of the p53 Family

Autor: Antonio Gentilella, Raffaela Santoro, Girolama La Mantia, Gelsomina Mansueto, Luisa Guerrini, Alessandra Pollice, Viola Calabrò, Pamela Ghioni

Publikováno v: Molecular and Cellular Biology. 24:8529-8540

The ARF/MDM2/p53 pathway is a principal defense mechanism to protect the organism from uncontrolled effects of deregulated oncogenes. Oncogenes activate ARF, which interacts with and inhibits the ubiquitin ligase MDM2, resulting in p53 stabilization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac5d074e324426699a49c6af498bd27
https://doi.org/10.1128/mcb.24.19.8529-8540.2004

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Inhibition of p63 Transcriptional activity by p14ARF : Functional and Physical Link between Human ARF Tumor Suppressor and a Member of the p53 Family

Autor: Viola, Calabr, Gelsomina, Mansueto, Raffaela, Santoro, Gentilella, Antonio, Alessandra, Pollice, Pamela, Ghioni, LUISA GUERRINI AND GIROLAMA LA MANTIA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3666::2d19fa0d0a07faaab895478cb7e5489d
http://hdl.handle.net/11386/2290153

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Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains

Autor: Luisa Guerrini, Fabrizio Bolognese, Pamela Ghioni, Roberto Mantovani, Pascal H.G. Duijf, Hans van Bokhoven

Publikováno v: Molecular and Cellular Biology, 22, 8659-68
Molecular and Cellular Biology, 22, 24, pp. 8659-68

Item does not contain fulltext p63 is a transcription factor structurally related to the p53 tumor suppressor. The C-terminal region differs from p53's in that it contains a sterile alpha motif (SAM) domain and is subject to multiple alternative spli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66fcbddc89766270c1c5950fd4e5ab5f
http://hdl.handle.net/2066/186519

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