Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Pamela Dumas"'
Publikováno v:
Cancer. 85:2336-2339
BACKGROUND A combination of etoposide, 5-fluorouracil, and folinic acid (ELF) remains popular for the treatment of patients with gastric carcinoma and has been reported to result in a response rate of up to 40% with good patient tolerance. The author
Autor:
Pamela Dumas, Jaffer A. Ajani, Richard Pazdur, Andrew M. Lowy, Steven D. Leach, Paul F. Mansfield
Publikováno v:
Annals of Surgery. 229:303-308
ObjectiveIn Western populations, long-term survival rates after curative resection of gastric cancer remain extremely poor. The lack of effective adjuvant therapy has prompted the evaluation of neoadjuvant approaches. Since 1988, we have conducted th
Autor:
Pamela Dumas, John Coyle, J. Jack Lee, Richard Pazdur, Robert De Jager, Yvonne Lassere, Melanie E. Royce, Paulo M. Hoff, M. P. Ducharme
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 19(5)
PURPOSE: To determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), pharmacokinetic (PK) profile, and recommended phase II dose of Exatecan mesylate (DX-8951f) when administered as a 24-hour continuous infusion every 3 weeks to pati
Autor:
C. Humberto Carrasco, David D. Lawrence, W. R. Richli, Yeul Hong Kim, Jaffer A. Ajani, Sidney Wallace, Pamela Dumas, Vincent P. Chuang
Publikováno v:
Cancer investigation. 17(7)
In many patients with liver metastases from islet cell or carcinoid tumor, vascular occlusion therapy results in prolonged control of symptoms, biochemical response, and also tumor regression. Chemotherapy agents were added to evaluate safety and eff
Publikováno v:
Investigational new drugs. 16(2)
Purpose: Taxol represents a new class of anticancer agents with activity against a wide variety of solid tumors. In preclinical systems, its cytotoxicity is schedule dependent with prolonged exposure being more effective. We studied a 120-hour infusi
Preoperative and postoperative combination chemotherapy for potentially resectable gastric carcinoma
Autor:
David M. Ota, Robert J. Mayer, Mark S. Roh, Jaffer A. Ajani, Catherine Gray, Donald M. Stablein, Donald A. Vena, David J. Sugarbaker, Glenn Steele, Pamela Dumas, Douglas B. Evans
Publikováno v:
Journal of the National Cancer Institute. 85(22)
Background Median survival of patients with local-regional gastric carcinoma is 10 months. Resection of the primary tumor and regional lymph nodes, with tumor-free margins (curative resection), has been the most effective treatment for local-regional
Autor:
Peter W.T. Pisters, David M. Ota, Douglas B. Evans, Pamela Dumas, Paul F. Mansfield, Barry W. Feig, Jaffer A. Ajani, Stephen Curley, I. Raijman, Kristin Hargraves, Patrick M. Lynch
Publikováno v:
Journal of Clinical Oncology. 17:2403-2403
PURPOSE: Patients with local-regional gastric carcinoma have a low rate of curative resection (R0) because of the advanced stage at diagnosis and suboptimal clinical staging. This study was designed to improve clinical staging with the use of laparos