Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Pamela D. Twigg"'
Publikováno v:
Cancer drug resistance (Alhambra, Calif.). 2(3)
Gliomas are the most common form of central nervous system tumor. The most prevalent form, glioblastoma multiforme, is also the most deadly with mean survival times that are less than 15 months. Therapies are severely limited by the ability of these
Publikováno v:
The American Biology Teacher. 73:444-448
We describe the implementation of "APPLE for the Teacher," an alternative education outreach program that augments teacher efforts in presenting specific AP Biology laboratory exercises and at the same time involves the community in the educational p
Autor:
Randall C. Wilson, Ronny C. Hughes, Pamela D. Twigg, Justin W. Flatt, Edward J. Meehan, Joseph D. Ng
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 65:440-444
The ubiquitin-conjugating enzyme E2-25K has been identified as a huntingtin (the key protein in Huntington's disease) interacting protein and has been shown to play a role in mediating the toxicity of Abeta, the principal protein involved in Alzheime
Publikováno v:
Proceedings of the National Academy of Sciences. 98:11259-11264
Understanding how metal binding regulates the activity of the diphtheria toxin repressor protein (DtxR) requires information about the structure in solution. We have prepared a DtxR mutant construct with three additional N-terminal residues, Gly-Ser-
Autor:
Jenny Chapman, Jean-Pierre Wery, Anna M. Stevens, Joseph X. Ho, Chong-Hwan Chang, Christine Evrard, Kerry Moody, Kim M. Keeling, Melissa White, Jean-Paul Declercq, Bi-Cheng Wang, Brenda Wright, W. Stallings, John Rose, Lawana Adcock-Downey, Paul J. Ala, Mark Wardell, David K. Clawson, John M. Rosenberg, Daniel C. Carter, John R. Ruble, James Click, Teresa Y. Miller, Pamela D. Twigg, Tim Dowling
Publikováno v:
Journal of Crystal Growth. 196:610-622
A facility-based protein crystallization apparatus for microgravity (PCAM) has been constructed and flown on a series of Space Shuttle Missions. The hardware development was undertaken largely because of the many important examples of quality improve
Autor:
Daniel C. Carter, John R. Ruble, James Click, Pamela D. Twigg, Kerry Moody, Teresa Y. Miller, Joseph X. Ho, Melissa White, Jenny Chapman, Brenda Wright, Joel M. Harp, Kim M. Keeling, Gerard J. Bunick, Lawana Adcock-Downey
Publikováno v:
Journal of Crystal Growth. 196:602-609
A versatile microdialysis counterdiffusion apparatus was developed in response to special exploratory opportunities for long-duration protein crystal growth experiments presented by the US and Russian Space Program. Challenged to reduce man-tended de
Autor:
Jenny Chapman, Pamela D. Twigg, Brenda Wright, Daniel C. Carter, Teresa Y. Miller, Kap Lim, John R. Ruble, A. A. Chernov, Franz Rosenberger, Joseph X. Ho, Peter G. Vekilov, Kim M. Keeling, B. R. Thomas
Publikováno v:
Journal of Crystal Growth. 196:623-637
Crystals of tetragonal hen egg white lysozyme (HEWL) grown on a series of space missions and their terrestrial counterparts were analyzed by gel electrophoresis and X-ray diffraction. The crystals were produced by vapor-diffusion and dialysis methods
Publikováno v:
Natural product communications. 6(10)
An extract of bark from the tropical rainforest plant Byrsonima crassifolia was screened for inhibition of diubiquitin formation by the human ubiquitin-conjugating enzyme E2-25K. Activity assays with both the full-length enzyme and a truncated, activ
Publikováno v:
European Journal of Biochemistry. 215:205-212
The amino-acid sequence and three-dimensional structure of equine serum albumin have been determined. The amino-acid sequence was deduced from cDNA isolated from equine liver. Comparisons of the primary structure of equine serum albumin with human se
Autor:
Lata Prasad, J. Wilson Quail, L.L. Clancy, Patricia C. Weber, H.M. Einspahr, Louis T. J. Delbaere, Charles E. Bugg, M. Vandonselaar, Robert S. Snyder, Xiao-Min He, Craig D. Smith, Daniel C. Carter, J.V. Schloss, Pamela D. Twigg, Alexander McPherson, S. Koszelak, Lawrence J. DeLucas
Publikováno v:
DeLucas, LJ; Smith, CD; Carter, DC; Twigg, P; He, XM; Snyder, RS; et al.(1992). Protein crystal growth aboard the U.S. space shuttle flights STS-31 and STS-32. Advances in Space Research, 12(1), 393-400. doi: 10.1016/0273-1177(92)90310-T. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/26c2d7n6
The first microgravity protein crystal growth experiments were performed on Spacelab I by Littke and John. These experiments indicated that the space grown crystals, which were obtained using a liquid-liquid diffusion system, were larger than crystal