High incidence of imperforate vagina in ADGRA3-deficient mice

Autor: Jone Marita Kvam, Maja Lind Nybo, Lola Torz, Riia Karolina Sustarsic, Kristian Høj Reveles Jensen, John Erik Nielsen, Hanne Frederiksen, Sarina Gadgaard, Katja Spiess, Steen Seier Poulsen, Jesper Skovhus Thomsen, Pamela Cowin, Martin Blomberg Jensen, Takeshi Kurita, Mette Marie Rosenkilde

Publikováno v: BMC Biology, Vol 22, Iss 1, Pp 1-14 (2024)

Abstract Background Ten percent of the female population suffers from congenital abnormalities of the vagina, uterus, or oviducts, with severe consequences for reproductive and psychological health. Yet, the underlying causes of most of these malform

Externí odkaz: https://doaj.org/article/cbc282de4565446c8b17c22dbf377664

Gli activity is critical at multiple stages of embryonic mammary and nipple development.

Autor: Anupama Chandramouli, Sarah J Hatsell, Alicia Pinderhughes, Lisa Koetz, Pamela Cowin

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e79845 (2013)

Gli3 is a transcriptional regulator of Hedgehog (Hh) signaling that functions as a repressor (Gli3(R)) or activator (Gli3(A)) depending upon cellular context. Previously, we have shown that Gli3(R) is required for the formation of mammary placodes #3

Externí odkaz: https://doaj.org/article/5dd01fde7e064b38bc806d9473396989

Correction: MMTV-Wnt1 and -ΔN89β-Catenin Induce Canonical Signaling in Distinct Progenitors and Differentially Activate Hedgehog Signaling within Mammary Tumors.

Autor: Brigitte Teissedre, Alicia Pinderhughes, Angela Incassati, Sarah J. Hatsell, Minoti Hiremath, Pamela Cowin

Publikováno v: PLoS ONE, Vol 4, Iss 3 (2009)

Externí odkaz: https://doaj.org/article/8043a3f9b3cb401f960ece1ac44f69ec

Optopharmacological tools for precise spatiotemporal control of oxytocin signaling in the central nervous system and periphery

Autor: Robert Froemke, Ismail Ahmed, Jingjing Liu, Krystyna Gieniec, Chloe Bair-Marshall, Ayomiposi Adewakun, Belinda Hetzler, Christopher Arp, Latika Khatri, Gilles Vanwalleghem, Alec Seidenberg, Pamela Cowin, Dirk Trauner, Moses Chao, Felicity Davis, Richard Tsien

Oxytocin is a neuropeptide critical for maternal physiology and social behavior, and is thought to be dysregulated in several neuropsychiatric disorders. Despite the biological and neurocognitive importance of oxytocin signaling, methods are lacking

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c8e1014eb5b057596f8437303d9d077
https://doi.org/10.21203/rs.3.rs-2715993/v1

Optopharmacological tools for precise spatiotemporal control of oxytocin signaling in the central nervous system and periphery

Autor: Ismail A. Ahmed, Jing-Jing Liu, Krystyna A. Gieniec, Chloe J. Bair-Marshall, Ayomiposi B. Adewakun, Belinda E. Hetzler, Christopher J. Arp, Latika Khatri, Gilles C. Vanwalleghem, Alec T. Seidenberg, Pamela Cowin, Dirk Trauner, Moses V. Chao, Felicity M. Davis, Richard W. Tsien, Robert C. Froemke

Publikováno v: Ahmed, I A, Liu, J-J, Gieniec, K A, Bair-Marshall, C J, Adewakun, A B, Hetzler, B E, Arp, C J, Khatri, L, Vanwalleghem, G C, Seidenberg, A T, Cowin, P, Trauner, D, Chao, M V, Davis, F M, Tsien, R W & Froemke, R C 2022, ' Optopharmacological tools for precise spatiotemporal control of oxytocin signaling in the central nervous system and periphery ', bioRxiv . https://doi.org/10.1101/2022.11.10.516001

Oxytocin is a neuropeptide critical for maternal physiology and social behavior, and is thought to be dysregulated in several neuropsychiatric disorders. Despite the biological and neurocognitive importance of oxytocin signaling, methods are lacking

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0a6861deeb949ce47fc03514083ca2
https://pure.au.dk/portal/da/publications/optopharmacological-tools-for-precise-spatiotemporal-control-of-oxytocin-signaling-in-the-central-nervous-system-and-periphery(d2feb2a8-e9b0-4e22-ad93-fdadae6a0bd7).html