Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Pamela C. Powell"'
Autor:
Pamela C. Powell, Chih-Chang Wei, Lianwu Fu, Betty Pat, Wayne E. Bradley, James F. Collawn, Louis J. Dell'Italia
Publikováno v:
Heliyon, Vol 5, Iss 4, Pp e01397- (2019)
Background: Volume overload (VO) of isolated mitral regurgitation (MR) or aortocaval fistula (ACF) is associated with extracellular matrix degradation and cardiomyocyte myofibrillar and desmin breakdown. Left ventricular (LV) chymase activity is incr
Externí odkaz:
https://doaj.org/article/f0c9f53d56864ba4a87ea2a3ef3f4d88
Autor:
Kyle W. Eudailey, Betty Pat, Joo-Yeun Oh, Pamela C. Powell, James F. Collawn, James A. Mobley, Amit Gaggar, Clifton T. Lewis, James E. Davies, Rakesh Patel, Louis J. Dell’Italia
Publikováno v:
The Annals of Thoracic Surgery.
Patients with valvular heart disease require cardiopulmonary bypass and cardiac arrest. Here, we test the hypothesis that exosomal hemoglobin formed during cardiopulmonary bypass mediates acute cardiac injury in humans and in an animal model system.P
Autor:
Inmaculada Aban, Thomas S. Denney, Navkaranbir S. Bajaj, Mustafa I. Ahmed, Michael J. Watson, Carlos M. Ferrario, Xiaoxia Zhang, James E. Davies, Himanshu Gupta, James W. McNamara, Betty Pat, Clifton T. Lewis, Louis J. Dell’Italia, James F. Collawn, Silvio H. Litovsky, Sakthivel Sadayappan, Brittany Butts, Steven G. Lloyd, Pamela C. Powell
Publikováno v:
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 5, Iss 2, Pp 109-122 (2020)
JACC: Basic to Translational Science, Vol 5, Iss 2, Pp 109-122 (2020)
Visual Abstract
Highlights • Extensive LA fibrosis is related to an increase in LA size and decrease in total LA EF. This supports the contention that the LA is not merely a bystander of MR but rather is actively involved in the pathophysiolog
Highlights • Extensive LA fibrosis is related to an increase in LA size and decrease in total LA EF. This supports the contention that the LA is not merely a bystander of MR but rather is actively involved in the pathophysiolog
Autor:
Nilam Vetal, Shama Ahmad, Nithya Mariappan, Pamela C. Powell, Stephen F. Doran, Aftab Ahmad, David A. Ford, Juan Xavier Masjoan Juncos, Wayne E. Bradley, Iram Zafar, Chih-Chang Wei, Sadis Matalon, William E. Louch, Ahmed Zaky, Louis J. Dell’Italia
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 316:H212-H223
Halogens are widely used, highly toxic chemicals that pose a potential threat to humans because of their abundance. Halogens such as bromine (Br2) cause severe pulmonary and systemic injuries; however, the mechanisms of their toxicity are largely unk
Autor:
Junying Zheng, Chih-Chang Wei, Naoki Hase, Ke Shi, Cheryl R Killingsworth, Silvio H Litovsky, Pamela C Powell, Tsunefumi Kobayashi, Carlos M Ferrario, Andras Rab, Inmaculada Aban, James F Collawn, Louis J Dell'Italia
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94732 (2014)
Cardiac ischemia and reperfusion (I/R) injury occurs because the acute increase in oxidative/inflammatory stress during reperfusion culminates in the death of cardiomyocytes. Currently, there is no drug utilized clinically that attenuates I/R injury
Externí odkaz:
https://doaj.org/article/cf8463926e934cdd9a6b21a673a2fc6d
Autor:
Aftab Ahmad, Chih-Chang Wei, Pamela C. Powell, William E. Louch, Wayne E. Bradley, Louis J. Dell’Italia, Nithya Mariappan, David A. Ford, Juan Xavier Masjoan Juncos, Shama Ahmad, Iram Zafar, Shazia Shakil
Publikováno v:
Arch Toxicol
Accidental bromine spills are common and its large industrial stores risk potential terrorist attacks. The mechanisms of bromine toxicity and effective therapeutic strategies are unknown. Our studies demonstrate that inhaled bromine causes deleteriou
Autor:
Joo-Yeun Oh, Michael Mrug, Clifton T. Lewis, Joshua S. Richman, James E. Davies, Pamela C. Powell, Juan Xavier Masjoan Juncos, Inmaculada Aban, Wayne E. Bradley, Betty Pat, Louis J. Dell’Italia, David Middleton, James F. Collawn, Orlando M. Gutiérrez, Rakesh P. Patel, Efstathia Andrikopoulou
Publikováno v:
The Journal of thoracic and cardiovascular surgery. 164(6)
Objective Hemolysis, characterized by formation of free hemoglobin (Hb), occurs in patients undergoing cardiopulmonary bypass (CPB). However, there is no study of the dynamic changes in red blood cell (RBC)-derived exosomes (Exos) released during CPB
Autor:
Jason L. Guichard, Lianwu Fu, Pamela C. Powell, James F. Collawn, Giulio Agnetti, Louis J. Dell'Italia, Michael Rogowski, Chih-Chang Wei
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 313:H32-H45
Heart failure due to chronic volume overload (VO) in rats and humans is characterized by disorganization of the cardiomyocyte desmin/mitochondrial network. Here, we tested the hypothesis that desmin breakdown is an early and continuous process throug
Autor:
Chih-Chang Wei, Pamela C. Powell, Wayne E. Bradley, Aftab Ahmad, Nithya Mariappan, David A. Ford, Louis J. Dell'Italia, Juan Xavier Masjoan Juncos, Shama Ahmad, William E. Louch, Iram Zafar
Publikováno v:
B25. OCCUPATIONAL EXPOSURES INCLUDING DEPLOYMENT RELATED, MINING, AND AGRICULTURE.
Autor:
Pamela C. Powell, Lianwu Fu, Wayne E. Bradley, Chih-Chang Wei, James F. Collawn, Louis J. Dell'Italia, Betty Pat
Publikováno v:
Heliyon
Heliyon, Vol 5, Iss 4, Pp e01397-(2019)
Heliyon, Vol 5, Iss 4, Pp e01397-(2019)
Background Volume overload (VO) of isolated mitral regurgitation (MR) or aortocaval fistula (ACF) is associated with extracellular matrix degradation and cardiomyocyte myofibrillar and desmin breakdown. Left ventricular (LV) chymase activity is incre