Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Pamela B. Garlick"'
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 292:H2009-H2019
Whereas glucose transporter 1 (GLUT-1) is thought to be responsible for basal glucose uptake in cardiac myocytes, little is known about its relative distribution between the different plasma membranes and cell types in the heart. GLUT-4 translocates
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 292:H378-H386
Hexokinase is responsible for glucose phosphorylation, a process fundamental to regulating glucose uptake. In some tissues, hexokinase translocates to the mitochondria, thereby increasing its efficiency and decreasing its susceptibility to product in
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 83:174-182
The buffer-perfused Langendorff heart is significantly vasodilated compared with the in vivo heart. In this study, we employed ultrasound to determine if this vasodilation translated into changes in left ventricular wall thickness (LVWT), and if this
Publikováno v:
NMR in Biomedicine. 16:494-502
2-Fluoro-[(18)F]-2-deoxy-glucose (FDG) is a positron-emitting analogue of glucose used clinically in positron emission tomography (PET) to assess glucose utilization in diseased and healthy tissue. Originally developed to measure local cerebral gluco
Autor:
Pamela B. Garlick
Publikováno v:
The British Journal of Radiology. 75:S60-S66
Using the system described by Paul Marsden et al [1], it is possible to acquire simultaneous PET scans and NMR spectra from isolated, perfused rat hearts. The results from three separate series of experiments will be described: firstly, pilot experim
Autor:
AA Flynn, Richard Southworth, Rodolfo A. Medina, Jason L. J. Dearling, R. Barbara Pedley, Pamela B. Garlick
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 29:1334-1341
Fluorine-18 fluoro-2-deoxyglucose ((18)FDG) and carbon-14 2-deoxyglucose ((14)C-2-DG) are both widely used tracers of myocardial glucose uptake and phosphorylation. We have recently shown, using positron emission tomography (PET) and nuclear magnetic
Publikováno v:
ResearcherID
We have determined the effect of lactate on the translocation of GLUT1 and GLUT4 and on the myocardial uptake and phosphorylation of the glucose analogues 2-deoxy-D-glucose (DG) and 2-18F-fluoro-2-deoxy-D-glucose (18FDG). The involvement of phosphati
Publikováno v:
Journal of Molecular and Cellular Cardiology. 32:853-858
NMR spectroscopy is an invaluable technique in metabolic investigations of isolated, perfused hearts. Most studies employ global perfusion methods together with an NMR coil that surrounds the heart and thus detects signals from its entirety. The pres
Autor:
Pamela B. Garlick, Alison C. Cave
Publikováno v:
Journal of Molecular and Cellular Cardiology. 32:415-427
Several studies have shown that the protective effect of ischemic preconditioning (PC) is associated with decreased calcium release from the sarcoplasmic reticulum (SR). However, no study has yet demonstrated whether these changes are essential in th
Autor:
Gavin Brown, Pamela B. Garlick
Publikováno v:
BMJ. 336:1111-1113
The extended medical degree programme at King’s College London shows that widening participation in medicine can be successful, but requires appreciable extra commitment by academic staff