Phenotypes controlled by the Brucella abortus two component system BvrR/BvrS are differentially impacted by BvrR phosphorylation

Autor: Pamela Altamirano-Silva, Jazmín Meza-Torres, Ana Mariel Zúñiga-Pereira, Sigrid Zamora-Jaen, Natalia Pietrosemoli, Gabriela Cantos, Johann Peltier, Javier Pizarro-Cerdá, Edgardo Moreno, Carlos Chacón-Díaz, Caterina Guzmán-Verri, Esteban Chaves-Olarte

Publikováno v: Frontiers in Microbiology, Vol 14 (2023)

Brucella abortus is a zoonotic pathogen whose virulence depends on its ability to survive intracellularly at the endoplasmic reticulum derived compartment. The two-component system BvrR/BvrS (BvrRS) is essential for intracellular survival due to the

Externí odkaz: https://doaj.org/article/e4851e588e4f4f6e81bb4828fa4c9377

A Sinorhizobium meliloti and Agrobacterium tumefaciens ExoR ortholog is not crucial for Brucella abortus virulence.

Autor: Amanda Castillo-Zeledón, Nazareth Ruiz-Villalobos, Pamela Altamirano-Silva, Carlos Chacón-Díaz, Elías Barquero-Calvo, Esteban Chaves-Olarte, Caterina Guzmán-Verri

Publikováno v: PLoS ONE, Vol 16, Iss 8, p e0254568 (2021)

Brucella is a facultative extracellular-intracellular pathogen that belongs to the Alphaproteobacteria class. Precise sensing of environmental changes and a proper response mediated by a gene expression regulatory network are essential for this patho

Externí odkaz: https://doaj.org/article/9b596ed25bcd4900a45d9cc4dae2ff33

Elucidating dynamic anaerobe metabolism with HRMAS 13C NMR and genome-scale modeling

Autor: Aidan Pavao, Brintha Girinathan, Johann Peltier, Pamela Altamirano Silva, Bruno Dupuy, Isabella H. Muti, Craig Malloy, Leo L. Cheng, Lynn Bry

Publikováno v: Nature Chemical Biology
Nature Chemical Biology, 2023, 19 (5), pp.556-564. ⟨10.1038/s41589-023-01275-9⟩

Anaerobic microbial metabolism drives critical functions within global ecosystems, host–microbiota interactions, and industrial applications, yet remains ill-defined. Here we advance a versatile approach to elaborate cellular metabolism in obligate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6095089b2423efae6cc39d5edb92a46
https://hal-pasteur.archives-ouvertes.fr/pasteur-04145606/document

Intracellular Passage Triggers a Molecular Response in Brucella abortus That Increases Its Infectiousness

Autor: Caterina Guzmán-Verri, Joselyn Méndez-Montoya, Edgardo Moreno, Esteban Chaves-Olarte, Carlos Chacón-Díaz, Marlen Cordero-Serrano, Pamela Altamirano-Silva

Publikováno v: Infect Immun

Brucella abortus is a facultatively extracellular-intracellular pathogen that encounters a diversity of environments within the host cell. We report that bacteria extracted from infected cells at late stages (48 h postinfection) of the intracellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bbd9e7f31231e514e28c80b35b49715
https://pubmed.ncbi.nlm.nih.gov/33820813

Neutrophils as Trojan Horse vehicles for Brucella abortus macrophage infection

Autor: Elías Barquero-Calvo, Carlos Chacón-Díaz, Esteban Chaves-Olarte, Ricardo Mora-Cartín, Cristina Gutiérrez-Jiménez, Edgardo Moreno, Pamela Altamirano-Silva

Publikováno v: Frontiers in Immunology Vol. 10 Article 1012 May 2019
Repositorio UNA
Universidad Nacional de Costa Rica
instacron:UNA
Frontiers in Inmunology/Microbial Inmunology
Kérwá
Universidad de Costa Rica
instacron:UCR
Frontiers in Immunology, Vol 10 (2019)

Brucella abortus is a stealthy intracellular bacterial pathogen of animals and humans. This bacterium promotes the premature cell death of neutrophils (PMN) and resists the killing action of these leukocytes. B. abortus-infected PMNs presented phosph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45068200e1457d0978ed1e34f6f1a949