Separating the Mechanism-Based and Off-Target Actions of Cholesteryl Ester Transfer Protein Inhibitors With CETP Gene Polymorphisms

Autor: Marcello Arca, François Cambien, Wiek H. van Gilst, Robin P. F. Dullaart, Michael J. Pencina, Shinji Yokoyama, Folkert W. Asselbergs, S. Matthijs Boekholdt, John F. Thompson, Aaron Isaacs, Jacqueline C.M. Witteman, Odette Poirer, Gerjan Navis, Pamela A. McCaskie, John E. Deanfield, Ian Ford, Aroon D. Hingorani, Viviane Nicaud, Carlo Gaudio, Nicholas J. Wareham, Bernhard Paulweber, Kay-Tee Khaw, Meena Kumari, Dirk J. van Veldhuisen, Lyle J. Palmer, Naveed Sattar, Ramachandran S. Vasan, José V. Sorlí, Jose M. Ordovas, Sally L. Ricketts, Heikki Kauma, Benjamin D. Horne, Mika Kivimäki, Philippa J. Talmud, Fabiana Quagliarini, Juan P. Casas, Steve E. Humphries, Tina Shah, Reecha Sofat, Shah Ebrahim, A. Sandhofer, John J.P. Kastelein, Dilys J. Freeman, Kenji Okumura, Jackie A. Cooper, Debbie A Lawlor, Tricia Li, Liam Smeeth, Cornelia M. van Duijn, Chris J. Packard, Akimoto Goto, Sakari Kakko, Pim van der Harst, Manjinder S. Sandhu, Ralph B. D'Agostino, Michael Marmot, Y. Antero Kesäniemi, Vilmundur Gudnason, Valerie McCormack, Markku J. Savolainen, George Davey Smith

Publikováno v: Circulation, 121(1), 52-62. LIPPINCOTT WILLIAMS & WILKINS
Circulation, 121(1), 52-62. Lippincott Williams and Wilkins
SOFAT, Reecha ; Hingorani, Aroon D. ; Smeeth, Liam ; Humphries, Steve E. ; Talmud, Philippa J. ; Cooper, Jackie ; Shah, Tina ; Sandhu, Manjinder S. ; Ricketts, Sally L. ; Boekholdt, S. Matthijs ; Wareham, Nicholas ; Khaw Kay, Tee ; Kumari, Meena ; Kivimaki, Mika ; Marmot, Michael ; Asselbergs, Folkert W. ; Van der Harst, Pim ; Dullaart, Robin P.F. ; Navis, Gerjanvan ; Veldhuisen, Dirk J. ; Van Gilst, Wiek H. ; Thompson, John F. ; McCaskie, Pamela ; Palmer, Lyle J. ; Arca, Marcello ; Quagliarini, Fabiana ; Gaudio, Carlo ; Cambien, François ; Nicaud, Viviane ; Poirer, Odette ; Gudnason, Vilmundur ; Isaacs, Aaron ; Witteman, Jacqueline C.M. ; van Duijn, Cornelia M., Pencina, Michael ; Vasan, Ramachandran S. ; D'Agostino, Ralph B. ; Ordovas, Jose ; Li, Tricia Y. ; Kakko, Sakari ; Kauma, Heikki ; Savolainen, Markku J. ; Kesäniemi, Antero ; Sandhofer, Anton ; Paulweber, Bernhard ; Sorli Guerola, Jose Vicente ; Goto, Akimoto ; Yokoyama, Shinji ; Okumura, Kenji ; Horne, Benjamin D. ; Packard, Chris ; Freeman, Dilys ; Ford, Ian ; Sattar, Naveed ; McCormack, Valerie ; Lawlor, Debbie A. ; Ebrahim, Shah ; Smith, George Davey ; Kastelein, John J.P. ; Deanfield, John ; Casas, Juan P., 2010, Separating the Mechanism-Based and Off-Target Actions of Cholesteryl Ester Transfer Protein Inhibitors With CETP Gene Polymorphisms, Circulation, vol. 121, no. 1, p. 52-62
RODERIC. Repositorio Institucional de la Universitat de Valéncia
instname
Circulation, 121(1), 52-62. Lippincott Williams & Wilkins

Background— Cholesteryl ester transfer protein (CETP) inhibitors raise high-density lipoprotein (HDL) cholesterol, but torcetrapib, the first-in-class inhibitor tested in a large outcome trial, caused an unexpected blood pressure elevation and incr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d85dcd349a5e8e8e03059538914974
https://research.rug.nl/en/publications/924a1e72-42e0-4e64-8148-c14a3395994e

Association of PARL rs3732581 genetic variant with insulin levels, metabolic syndrome and coronary artery disease

Autor: Pamela A. McCaskie, Steven Wiltshire, Peter L. Thompson, John Beilby, Brendan McQuillan, Lyle J. Palmer, Kim W. Carter, Brenda Powell, Joseph Hung, Gillian M. Arscott

Publikováno v: Human Genetics. 124:263-270

PARL (presenilin-associated rhomboid-like) is a mitochondrial protein involved in mitochondrial membrane remodelling, and maps to a quantitative trait locus (3q27) associated with metabolic traits. Recently the rs3732581 (Leu262Val) variant was found

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3e7d370172447cbaeac631d3c444fb
https://doi.org/10.1007/s00439-008-0552-2

The C-480T hepatic lipase polymorphism is associated with HDL-C but not with risk of coronary heart disease

Autor: Kim W. Carter, John Beilby, Pamela A. McCaskie, Brendan McQuillan, Caroline M. L. Chapman, Peter L. Thompson, Gemma Cadby, Lyle J. Palmer, Joseph Hung

Publikováno v: Europe PubMed Central

High-density lipoprotein cholesterol (HDL-C) is a known predictor of coronary heart disease (CHD). Studies have shown that the C-480T polymorphism of the hepatic lipase (HL) gene is predictive of HDL-C; however, its observed relationship with the ris

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d111def1ff32659af41d9b30ab79a5
https://doi.org/10.1111/j.1399-0004.2006.00659.x

SimHap GUI: An intuitive graphical user interface for genetic association analysis

Autor: Pamela A. McCaskie, Lyle J. Palmer, Kim W. Carter

Publikováno v: BMC Bioinformatics, Vol 9, Iss 1, p 557 (2008)
BMC Bioinformatics

Background Researchers wishing to conduct genetic association analysis involving single nucleotide polymorphisms (SNPs) or haplotypes are often confronted with the lack of user-friendly graphical analysis tools, requiring sophisticated statistical an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be22261b0edab178d8f8b99ef270f42
http://www.biomedcentral.com/1471-2105/9/557

Investigating the association between K198N coding polymorphism in EDN1 and hypertension, lipoprotein levels, the metabolic syndrome and cardiovascular disease

Autor: John Beilby, Joseph Hung, Steven Wiltshire, Brenda Powell, Pamela A. McCaskie, Michelle Jennens, Lyle J. Palmer, Brendan McQuillan, Kim W. Carter, Peter L. Thompson

Publikováno v: Human genetics. 123(3)

Endothelin-1 is a potent vasoconstrictor in the body. Previous studies have identified associations between the coding polymorphism K198N and hypertension, systolic blood pressure and HDL levels. We sought to examine the evidence for these associatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eae097715ff30103321a557c611047d
https://pubmed.ncbi.nlm.nih.gov/18288492