Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Pamela A. Marino"'
Autor:
Dieter Schrenk, Jeffrey A. Silverman, Karl-Heinz Preisegger, Timothy W. Gant, Pamela A. Marino, Snorri S. Thorgeirsson
Publikováno v:
Hepatology. 17:854-860
P-glycoprotein, an energy-dependent plasma membrane drug-efflux pump capable of reducing the intracellular concentration of a variety of hydrophobic xenobiotics, is encoded by mdr1, a member of the multidrug-resistant (mdr) gene family. The physiolog
Publikováno v:
Journal of Bacteriology. 173:3128-3133
The uncoupler 2,4-dinitrophenol prevents in vivo synthesis of O antigen in Salmonella typhimurium by inhibiting the first reaction of the pathway, formation of galactosyl-pyrophosphoryl-undecaprenol. Inhibition was observed only in intact cells; dini
Autor:
Snorri S. Thorgeirsson, Pamela A. Marino, Richard K. Burt, Timothy W. Gant, Jeffrey A. Silverman, Hanne Cathrine Bisgaard
Publikováno v:
Molecular Carcinogenesis. 4:499-509
Previous studies by this laboratory have indicated that expression of the multidrug resistance (mdr) gene can be increased in vivo by exposure to a variety of xenobiotics. Because of the nature of these compounds, it was proposed that mdr gene expres
Publikováno v:
Pharmacology & Therapeutics. 49:283-292
The data discussed in this review indicate that the coordinated induction of both the mdr gene family and a subfamily of the cytochrome P-450 supergene family provide a unified response of the organism to prevent lethal accumulation of xenobiotics. C
Autor:
J. Hanley-Hyde, Snorri S. Thorgeirsson, Thomas B. Tan, Lori L. Hampton, Pamela A. Marino, Raji Padmanabhan
Publikováno v:
In vitro cellulardevelopmental biology. Animal. (9)
Over-expression of transforming growth factor-alpha (TGF-alpha) is consistently seen in spontaneous transformants of rat liver derived epithelial cells (RLE phi 13) and has been implicated in the transformation of other cultured cells. We have consti
Autor:
Seamus A. Rooney, Ian Gross, Prabhat Seghal, Arthur J. Chu, Christine M. Wilson, Don B. Singer, Pamela A. Marino, John B. Susa, Robert Schwartz, Joseph B. Warshaw
Publikováno v:
Lung. 161:313-317
We examined the effect of hyperinsulinemia in the absence of hyperglycemia on parameters of lung surfactant production in the fetal rhesus monkey at 134–148 days gestation. Hyperinsulinemia was achieved by infusion of insulin for 21 d from an Alzet
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 572:64-76
Administration of betamethasone (0.2 mg/kg, intramuscularly) to pregnant rabbits had the following effects on the fetal lung at 26–27 days gestation. It increased the amount of phosphatidylcholine in lung lavage by 70% and almost doubled the phosph
Autor:
Seamus A. Rooney, Pamela A. Marino
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 664:389-396
We have studied the rate of surfactant secretion in a newborn rabbit lung slice model. Newborn rabbits were injected with [ Me - 3 H]choline and killed 4 h later. Secretion of phosphatidyl[ Me - 3 H]choline was measured in washed slices from blood-fr
Autor:
Seamus A. Rooney, Pamela A. Marino
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 620:509-519
We describe a slice model for the study of pulmonary surfactant secretion in newborn rabbits. Full term rabbits were delivered by cesarean section and injected intraperitoneally with [Me-3H]choline. Four hours later they were killed, the lungs were p
Publikováno v:
Pediatric research. 13(5 Pt 1)
Administration of thyrotropin-releasing hormone (TRH) to pregnant rabbits at 25 and 26 days of gestation results in increased pulmonary surfactant production by the fetus at 27 days (full term is 31 days). There was 60% more total phospholipid and 15