Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Pamela A. Hoodless"'
Autor:
Avinash Thakur, Kwangjin Park, Rebecca Cullum, Bettina M. Fuglerud, Mina Khoshnoodi, Sibyl Drissler, Tabea L. Stephan, Jeremy Lotto, Donghwan Kim, Frank J. Gonzalez, Pamela A. Hoodless
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Hepatocyte nuclear factor 4A (HNF4A/NR2a1), a transcriptional regulator of hepatocyte identity, controls genes that are crucial for liver functions, primarily through binding to enhancers. In mammalian cells, active and primed enhancers are
Externí odkaz:
https://doaj.org/article/509818b666a44a0e9f65dd70f8d00e81
Autor:
Jeremy Lotto, Rebecca Cullum, Sibyl Drissler, Martin Arostegui, Victoria C. Garside, Bettina M. Fuglerud, Makenna Clement-Ranney, Avinash Thakur, T. Michael Underhill, Pamela A. Hoodless
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Epithelial-to-mesenchymal transitions (EMTs) of both endocardium and epicardium guide atrioventricular heart valve formation, but the cellular complexity and small scale of this tissue have restricted analyses. To circumvent these issues, we
Externí odkaz:
https://doaj.org/article/a8e5d6366264478ba5947de946bd31c2
Autor:
Jung-Chien Cheng, Lanlan Fang, Yuxi Li, Avinash Thakur, Pamela A. Hoodless, Yanjie Guo, Zhen Wang, Ze Wu, Yang Yan, Qiongqiong Jia, Yibo Gao, Xiaoyu Han, Yiping Yu, Ying-Pu Sun
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Cheng, Fan, Li et al. identified ANGPTL4 as a G1-induced target gene of GPER/YAP in HRT8 cells using RNA-seq and highlighted its importance in regulating trophoblast cell invasion. The authors also reported GPER downregulation in the placenta and low
Externí odkaz:
https://doaj.org/article/c3858db132154bb18f592d1b774c2406
Autor:
Katsuyoshi Takata, Lauren C. Chong, Daisuke Ennishi, Tomohiro Aoki, Michael Yu Li, Avinash Thakur, Shannon Healy, Elena Viganò, Tao Dao, Daniel Kwon, Gerben Duns, Julie S. Nielsen, Susana Ben-Neriah, Ethan Tse, Stacy S. Hung, Merrill Boyle, Sung Soo Mun, Christopher M. Bourne, Bruce Woolcock, Adèle Telenius, Makoto Kishida, Shinya Rai, Allen W. Zhang, Ali Bashashati, Saeed Saberi, Gianluca D’Antonio, Brad H. Nelson, Sohrab P. Shah, Pamela A. Hoodless, Ari M. Melnick, Randy D. Gascoyne, Joseph M. Connors, David A. Scheinberg, Wendy Béguelin, David W. Scott, Christian Steidl
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
PRAME is a prominent member of the cancer testis antigen family of proteins, which triggers autologous T cell–mediated immune responses. Integrative genomic analysis in diffuse large B cell lymphoma (DLBCL) uncovered recurrent and highly focal dele
Externí odkaz:
https://doaj.org/article/1a16abd2d3774266828be223d0374b3a
Autor:
Ping Xiang, Wei Wei, Nicole Hofs, Jack Clemans-Gibbon, Tobias Maetzig, Courteney K. Lai, Ishpreet Dhillon, Christopher May, Jens Ruschmann, Edith Schneider, Patricia Rosten, Kaiji Hu, Florian Kuchenbauer, Pamela A. Hoodless, R. Keith Humphries
Publikováno v:
Blood Advances, Vol 1, Iss 24, Pp 2225-2235 (2017)
Abstract: Myeloid ecotropic viral integration site 1 (MEIS1), a HOX transcription cofactor, is a critical regulator of normal hematopoiesis, and its overexpression is implicated in a wide range of leukemias. Using the clustered regularly interspaced
Externí odkaz:
https://doaj.org/article/177ee9c1a2934b1bb4877ae28a97a7d0
Autor:
Laina Freyer, Chih-Wei Hsu, Sonja Nowotschin, Andrea Pauli, Junji Ishida, Keiji Kuba, Akiyoshi Fukamizu, Alexander F. Schier, Pamela A. Hoodless, Mary E. Dickinson, Anna-Katerina Hadjantonakis
Publikováno v:
Cell Reports, Vol 20, Iss 9, Pp 2116-2130 (2017)
Apela (also known as Elabela, Ende, and Toddler) is a small signaling peptide that activates the G-protein-coupled receptor Aplnr to stimulate cell migration during zebrafish gastrulation. Here, using CRISPR/Cas9 to generate a null, reporter-expressi
Externí odkaz:
https://doaj.org/article/f75a376d0e9947a199eb00478091e6b8
Autor:
Patrick Coulombe, Grigorios N. Paliouras, Ashley Clayton, Angela Hussainkhel, Megan Fuller, Vida Jovanovic, Shauna Dauphinee, Patricia Umlandt, Ping Xiang, Alistair H. Kyle, Andrew I. Minchinton, R. Keith Humphries, Pamela A. Hoodless, Jeremy D.K. Parker, Joanne L. Wright, Aly Karsan
Publikováno v:
Cell Reports, Vol 27, Iss 6, Pp 1769-1780.e4 (2019)
Summary: The sterile alpha motif (SAM) and SRC homology 3 (SH3) domain containing protein 1 (Sash1) acts as a scaffold in TLR4 signaling. We generated Sash1−/− mice, which die in the perinatal period due to respiratory distress. Constitutive or e
Externí odkaz:
https://doaj.org/article/7da597faf600423285c07b09a097bc00
Autor:
Olivia Alder, Rebecca Cullum, Sam Lee, Arohumam C. Kan, Wei Wei, Yuyin Yi, Victoria C. Garside, Misha Bilenky, Malachi Griffith, A. Sorana Morrissy, Gordon A. Robertson, Nina Thiessen, Yongjun Zhao, Qian Chen, Duojia Pan, Steven J.M. Jones, Marco A. Marra, Pamela A. Hoodless
Publikováno v:
Cell Reports, Vol 9, Iss 1, Pp 261-271 (2014)
Summary: Cell fate acquisition is heavily influenced by direct interactions between master regulators and tissue-specific enhancers. However, it remains unclear how lineage-specifying transcription factors, which are often expressed in both progenito
Externí odkaz:
https://doaj.org/article/0eaeca3af1814768b1d2f9059d4ef20c
Publikováno v:
Nature Reviews Gastroenterology & Hepatology.
Autor:
Ping Xiang, Xining Yang, Leo Escano, Ishpreet Dhillon, Edith Schneider, Jack Clemans-Gibbon, Wei Wei, Jasper Wong, Simon Xufeng Wang, Derek Tam, Yu Deng, Eric Yung, Gregg B. Morin, Pamela A. Hoodless, Martin Hirst, Aly Karsan, Florian Kuchenbauer, R. Keith Humphries, Arefeh Rouhi
Publikováno v:
Leukemia. 36:1980-1989
Myeloid ecotropic virus insertion site 1 (MEIS1) is essential for normal hematopoiesis and is a critical factor in the pathogenesis of a large subset of acute myeloid leukemia (AML). Despite the clinical relevance of MEIS1, its regulation is largely