Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Pamela A. Hershberger"'
Autor:
Florian Wittlinger, Blessing C. Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D. Pham, Ilse K. Schaeffner, Brandon T. Oligny, Surbhi P. Chitnis, Tyler S. Beyett, Alexander Rasch, Brian Buckley, Daniel A. Urul, Tatiana Shaurova, Earl W. May, Erik M. Schaefer, Michael J. Eck, Pamela A. Hershberger, Antti Poso, Stefan A. Laufer, David E. Heppner
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Bivalent molecules consisting of groups connected through bridging linkers often exhibit strong target binding and unique biological effects. However, developing bivalent inhibitors with the desired activity is challenging due to the dual mo
Externí odkaz:
https://doaj.org/article/4d98b317db4743c79540cdb1697614f4
Autor:
Zeinab Farhat, Tyler Scheving, Diana S. Aga, Pamela A. Hershberger, Jo L. Freudenheim, Rachael Hageman Blair, Manoj J. Mammen, Lina Mu
Publikováno v:
Nutrients, Vol 15, Iss 19, p 4099 (2023)
It is hypothesized that garlic, Allium sativum, might protect against oxidative stress that causes damage to cells and tissues leading to the development of various health conditions including cancer. However, it is not known whether garlic’s poten
Externí odkaz:
https://doaj.org/article/ff8f0c45badf4923ac4afadfb1c93a0d
Autor:
Brittany L. Bunch, Yingyu Ma, Kristopher Attwood, Lauren Amable, Wei Luo, Carl Morrison, Khurshid A. Guru, Anna Woloszynska‐Read, Pamela A. Hershberger, Donald L. Trump, Candace S. Johnson
Publikováno v:
Cancer Medicine, Vol 8, Iss 5, Pp 2449-2461 (2019)
Abstract Background Vitamin D3 (VitD) deficiency is linked to increased incidence and worse survival in bladder cancer (BCa). In addition to cystectomy, patients are treated with cisplatin‐based chemotherapy, however 30%‐50% of patients do not be
Externí odkaz:
https://doaj.org/article/22ca1c97f38345faa050654f631ae09d
Autor:
Vui King Vincent-Chong, Hendrik DeJong, Kristopher Attwood, Pamela A. Hershberger, Mukund Seshadri
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 4, Pp 376-388 (2019)
The anticancer activity of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3 or calcitriol) has been widely reported in preclinical models. However, systematic investigation into the chemopreventive potential of calcitriol against the spectrum of oral carcinogen
Externí odkaz:
https://doaj.org/article/1455be19c8114619b854253f4c1a5609
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Somatic alterations in the epidermal growth factor receptor gene (EGFR) result in aberrant activation of kinase signaling and occur in ∼15% of non-small cell lung cancers (NSCLC). Patients diagnosed with EGFR-mutant NSCLC have good initial clinical
Externí odkaz:
https://doaj.org/article/fd9bf04414b5437d8f22b9b1581aa1bc
Autor:
Pamela A. Hershberger, Song Liu, Moray Campbell, Maochun Qin, Suzanne Shoemaker, Alissa Verone, Santosh Kumar Upadhyay
Publikováno v:
Cancers, Vol 5, Iss 4, Pp 1504-1521 (2013)
1,25-dihydroxyvitamin D3 (1,25(OH)2D3) exerts anti-proliferative activity by binding to the vitamin D receptor (VDR) and regulating gene expression. We previously reported that non-small cell lung cancer (NSCLC) cells which harbor epidermal growth fa
Externí odkaz:
https://doaj.org/article/7e96aef4c4a44542b61121839738b64e
Autor:
Tatiana Shaurova, Lingyue Yan, Yafei Su, Laurie James Rich, Vui King Vincent‐Chong, Hannah Calkins, Saraswati Pokharel, Martin Petkovich, Mukund Seshadri, Yun Wu, Pamela Anne Hershberger
Publikováno v:
Cancer Communications. 43:503-507
Autor:
Candace S. Johnson, Donald L. Trump, Kristopher Atwood, Paul N. Bogner, Mary E. Reid, Pamela A. Hershberger, Sarah A. Mazzilli
Supplemental Table 1. Percent of Normal Airways, Atypia, Low-grade Dysplasia & High-grade Dysplasia Lesions Present in the Small Airways After NTCU Treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108d97f305ad27a6a1609ac6568b6d12
https://doi.org/10.1158/1940-6207.22526691.v1
https://doi.org/10.1158/1940-6207.22526691.v1
Autor:
Mukund Seshadri, Pamela A. Hershberger, Candace S. Johnson, Moni A. Kuriakose, Amritha Suresh, Mihai Merzianu, Tatiana Shaurova, Katelyn D. Bothwell
Activation of the epidermal growth factor receptor (EGFR) pathway is an early event in head and neck carcinogenesis. As a result, targeting EGFR for chemoprevention of head and neck squamous cell carcinomas (HNSCC) has received considerable attention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51d43a106051444d2f00456270f74a7b
https://doi.org/10.1158/1940-6207.c.6545339.v1
https://doi.org/10.1158/1940-6207.c.6545339.v1
Autor:
Mukund Seshadri, Pamela A. Hershberger, Candace S. Johnson, Moni A. Kuriakose, Amritha Suresh, Mihai Merzianu, Tatiana Shaurova, Katelyn D. Bothwell
Supplementary Fig. S1. MRI of 4NQO-induced tumor growth. Supplementary Fig. S2. MRI-based assessment of response to 1,25(OH)2D3 alone and in combination with erlotinib in the 4NQO model. Supplementary Fig. S3. Ex vivo assessment of response to combin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fbb3e231f9f9e4551b9feeb6b59db53
https://doi.org/10.1158/1940-6207.22527113
https://doi.org/10.1158/1940-6207.22527113